Chimeric Animal Inflammation Treatment Method

Publication ID: 24-11856927_0006_PTD
Published: October 26, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Chimeric Animal Inflammation Treatment Method,” Published Technical Disclosure No. 24-11856927_0006_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856927_0006_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,927.

Background and Problem Solved

The original patent disclosed a method for obtaining an adult individual from a xenogeneic or allogeneic chimeric animal fetus individual. However, the patent did not fully address the issue of inflammation after birth, which can lead to immune response and rejection of the chimeric cells. The present invention solves this problem by introducing a system and method for monitoring and treating inflammation in chimeric animals after birth, thereby improving their survival rate.

Novelty and Inventive Step

The present invention introduces a novel system and method for reducing inflammation in chimeric animals after birth, which is not addressed in the original patent. The inventive step lies in the combination of a monitoring unit and a treatment unit, as well as the composition and method for enhancing tolerance to allogeneic or xenogeneic cells.

Alternative Embodiments and Variations

Alternative embodiments of the invention include using different types of anti-inflammatory agents or immunosuppressive agents, varying the timing and dosage of administration, and incorporating additional components to the system and composition. Variations of the method for enhancing tolerance may include using different tolerance-inducing agents or adjusting the timing of administration.

Potential Commercial Applications and Market

The present invention has significant commercial potential in the field of regenerative medicine, particularly in the development of chimeric animal models for human disease research and therapy. The invention may also have applications in the veterinary industry for improving the health and survival rate of chimeric animals.

CPC Classifications

SectionClassGroup
A A01 A01K67/0271
A A61 A61K31/573
A A61 A61P37/06
A A01 A01K2217/05
A A01 A01K2217/075
A A01 A01K2227/105
A A01 A01K2267/035
C C12 C12N15/09

Original Patent Information

Patent NumberUS 11,856,927
TitleFinding and treatment of inflammation after birth in chimeric animal
Assignee(s)The University of Tokyo