Published Technical Disclosure Archive

Chimeric Animal Inflammation Treatment Method

Publication ID: 24-11856927_0006_PTD
Published: October 26, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Chimeric Animal Inflammation Treatment Method,” Published Technical Disclosure No. 24-11856927_0006_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856927_0006_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,927.

Background and Problem Solved

The original patent disclosed a method for obtaining an adult individual from a xenogeneic or allogeneic chimeric animal fetus individual. However, the patent did not fully address the issue of inflammation after birth, which can lead to immune response and rejection of the chimeric cells. The present invention solves this problem by introducing a system and method for monitoring and treating inflammation in chimeric animals after birth, thereby improving their survival rate.

Novelty and Inventive Step

The present invention introduces a novel system and method for reducing inflammation in chimeric animals after birth, which is not addressed in the original patent. The inventive step lies in the combination of a monitoring unit and a treatment unit, as well as the composition and method for enhancing tolerance to allogeneic or xenogeneic cells.

Alternative Embodiments and Variations

Alternative embodiments of the invention include using different types of anti-inflammatory agents or immunosuppressive agents, varying the timing and dosage of administration, and incorporating additional components to the system and composition. Variations of the method for enhancing tolerance may include using different tolerance-inducing agents or adjusting the timing of administration.

Potential Commercial Applications and Market

The present invention has significant commercial potential in the field of regenerative medicine, particularly in the development of chimeric animal models for human disease research and therapy. The invention may also have applications in the veterinary industry for improving the health and survival rate of chimeric animals.

CPC Classifications

SectionClassGroup
A A01 A01K67/0271
A A61 A61K31/573
A A61 A61P37/06
A A01 A01K2217/05
A A01 A01K2217/075
A A01 A01K2227/105
A A01 A01K2267/035
C C12 C12N15/09

Field of Art

Veterinary biotechnology and immunological research, specifically focused on chimeric animal development, stem cell transplantation, and immune response management in xenogeneic and allogeneic biological systems

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degrees in veterinary medicine, immunology, or molecular biology, possessing expertise in stem cell technologies, animal chimera development, and immunosuppressive treatment strategies

Obviousness Rationale

A person having ordinary skill would recognize that the PTD's proposed monitoring and treatment system represents a predictable extension of the source patent's core teachings about managing inflammation in chimeric animals. The additional elements of real-time monitoring and targeted intervention are logical refinements to the existing immunosuppression methodology disclosed in the original patent. The variations represent incremental improvements that would be apparent to a skilled practitioner seeking to optimize chimeric animal survival and immune response management.

Obvious Combinations & Variations

Source Patent Element
Method for obtaining an adult individual from a chimeric animal fetus with no substantial inflammation
PTD Variation
Adding a dedicated monitoring unit to detect immune response or inflammation in real-time
Obviousness Reasoning
Implementing monitoring technology is a known technique in medical research, representing a predictable solution for tracking biological conditions with well-established diagnostic methods
Source Patent Element
Administration of anti-inflammatory or immunosuppressive agents before immune response occurrence
PTD Variation
Introducing a tolerance-inducing agent before birth and supplemental treatment after birth
Obviousness Reasoning
Combining pre-birth and post-birth interventions represents a logical extension of existing immunomodulation strategies, utilizing known immunological principles
Source Patent Element
Treating immunodeficient chimeric animals to prevent post-birth inflammation
PTD Variation
Developing a comprehensive composition with carrier mechanisms for targeted agent delivery
Obviousness Reasoning
Designing specialized delivery mechanisms is a standard approach in pharmaceutical development, representing an obvious optimization of existing treatment protocols
Source Patent Element
Method focusing on preventing immune response after birth in chimeric animals
PTD Variation
Creating a system for improving survival rates through systematic monitoring and intervention
Obviousness Reasoning
Systematic approach to animal survival is a predictable goal in biotechnological research, utilizing known techniques for comprehensive medical management
Source Patent Element
Treating chimeric animals with immunosuppressive agents
PTD Variation
Expanding treatment protocols to include multiple types of anti-inflammatory and immunosuppressive agents
Obviousness Reasoning
Exploring alternative agents within a known therapeutic category represents a standard approach to developing more effective treatment strategies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11856927, the present publication demonstrates that the claimed variations in chimeric animal inflammation management would have been obvious to a person having ordinary skill in the art at the time of invention. The disclosed system and method represent predictable extensions of existing immunological intervention strategies, combining known techniques in monitoring, treatment, and biological intervention in a manner that would be readily apparent to a skilled practitioner in veterinary biotechnology.

Original Patent Information

Patent NumberUS 11,856,927
TitleFinding and treatment of inflammation after birth in chimeric animal
Assignee(s)The University of Tokyo