Immune Response Innovation: Chimeric Cell Therapy Breakthrough

Publication ID: 24-11856927_0007_PTD
Published: October 26, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Immune Response Innovation: Chimeric Cell Therapy Breakthrough,” Published Technical Disclosure No. 24-11856927_0007_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856927_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,927.

Background and Problem Solved

The original patent addressed the challenge of immune response and inflammation in chimeric animals. However, its scope was limited to treating and preventing these responses in the context of chimeric animal development. This invention builds upon the original patent's core technology to expand its applicability to diverse biomedical fields, thereby solving the problem of limited translational potential.

Novelty and Inventive Step

The novelty of this invention lies in the application of the original patent's core technology to entirely new fields, thereby expanding its translational potential. The inventive step is the recognition that the chimeric animal models can be adapted to address specific biomedical challenges, and the development of novel methods and systems to achieve this.

Alternative Embodiments and Variations

Alternative embodiments of this invention could include the use of different types of stem cells, varying the timing and dosage of the treatment regimen, or incorporating additional components to enhance the chimeric animal model's functionality. Variations could also involve the development of chimeric animal models for other biomedical applications not explicitly mentioned in the new claims.

Potential Commercial Applications and Market

The commercial potential of this invention is vast, with potential applications in the fields of organ transplantation, cancer therapy, autoimmune disorder treatment, biomaterials, and tissue regeneration. The target market includes pharmaceutical and biotechnology companies, research institutions, and hospitals.

CPC Classifications

SectionClassGroup
A A01 A01K67/0271
A A61 A61K31/573
A A61 A61P37/06
A A01 A01K2217/05
A A01 A01K2217/075
A A01 A01K2227/105
A A01 A01K2267/035
C C12 C12N15/09

Field of Art

Biomedical research involving chimeric animal models, stem cell engineering, and immunological interventions, with expertise in genetic manipulation, cell transplantation, and immunomodulatory techniques

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degrees in molecular biology, immunology, or veterinary medicine, possessing comprehensive knowledge of stem cell technologies, genetic engineering, and immune system interactions

Obviousness Rationale

A PHOSITA would recognize that the source patent's fundamental approach to managing immune responses in chimeric animals provides a clear technological framework for extending the research into diverse biomedical applications. The core principles of immune modulation and chimeric cell manipulation are directly transferable across different medical contexts. The PTD's variations represent predictable extrapolations of the original patent's core technological insights, utilizing standard techniques in biomedical research.

Obvious Combinations & Variations

Source Patent Element
Method for preventing inflammation in chimeric animal models using immunosuppressive agents
PTD Variation
Applying chimeric cell models to organ transplant compatibility testing
Obviousness Reasoning
Predictable extension of immune modulation techniques to transplantation medicine, using known immunological screening methodologies
Source Patent Element
Techniques for managing immune responses in genetically modified animal models
PTD Variation
Developing personalized cancer therapy models using patient-specific chimeric cells
Obviousness Reasoning
Routine application of chimeric modeling techniques to precision medicine, representing a known approach in translational research
Source Patent Element
Immunodeficient chimeric animal generation method
PTD Variation
Creating chimeric models for testing biomaterial biocompatibility
Obviousness Reasoning
Standard scientific approach of adapting existing immunological screening techniques to materials science research
Source Patent Element
Stem cell transplantation and immune response management
PTD Variation
Developing compositions for regulating autoimmune disorder responses
Obviousness Reasoning
Logical progression of immunomodulatory techniques to therapeutic intervention strategies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11856927, a person of ordinary skill in the art would find the variations disclosed herein to be obvious extensions of the prior art, representing predictable applications of established chimeric animal modeling and immunomodulatory techniques. The disclosed variations constitute obvious combinations that would be readily conceived by a skilled practitioner without requiring inventive insight beyond the existing technological framework.

Original Patent Information

Patent NumberUS 11,856,927
TitleFinding and treatment of inflammation after birth in chimeric animal
Assignee(s)The University of Tokyo