Immune Response Innovation: Chimeric Cell Therapy Breakthrough
Legal Citation
Background and Problem Solved
The original patent addressed the challenge of immune response and inflammation in chimeric animals. However, its scope was limited to treating and preventing these responses in the context of chimeric animal development. This invention builds upon the original patent's core technology to expand its applicability to diverse biomedical fields, thereby solving the problem of limited translational potential.
Novelty and Inventive Step
The novelty of this invention lies in the application of the original patent's core technology to entirely new fields, thereby expanding its translational potential. The inventive step is the recognition that the chimeric animal models can be adapted to address specific biomedical challenges, and the development of novel methods and systems to achieve this.
Alternative Embodiments and Variations
Alternative embodiments of this invention could include the use of different types of stem cells, varying the timing and dosage of the treatment regimen, or incorporating additional components to enhance the chimeric animal model's functionality. Variations could also involve the development of chimeric animal models for other biomedical applications not explicitly mentioned in the new claims.
Potential Commercial Applications and Market
The commercial potential of this invention is vast, with potential applications in the fields of organ transplantation, cancer therapy, autoimmune disorder treatment, biomaterials, and tissue regeneration. The target market includes pharmaceutical and biotechnology companies, research institutions, and hospitals.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A01 | A01K67/0271 |
| A | A61 | A61K31/573 |
| A | A61 | A61P37/06 |
| A | A01 | A01K2217/05 |
| A | A01 | A01K2217/075 |
| A | A01 | A01K2227/105 |
| A | A01 | A01K2267/035 |
| C | C12 | C12N15/09 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Biomedical research involving chimeric animal models, stem cell engineering, and immunological interventions, with expertise in genetic manipulation, cell transplantation, and immunomodulatory techniques
Person of Ordinary Skill (PHOSITA) Profile
A researcher with advanced degrees in molecular biology, immunology, or veterinary medicine, possessing comprehensive knowledge of stem cell technologies, genetic engineering, and immune system interactions
Obviousness Rationale
A PHOSITA would recognize that the source patent's fundamental approach to managing immune responses in chimeric animals provides a clear technological framework for extending the research into diverse biomedical applications. The core principles of immune modulation and chimeric cell manipulation are directly transferable across different medical contexts. The PTD's variations represent predictable extrapolations of the original patent's core technological insights, utilizing standard techniques in biomedical research.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,856,927 |
|---|---|
| Title | Finding and treatment of inflammation after birth in chimeric animal |
| Assignee(s) | The University of Tokyo |