Immune Response Innovation: Chimeric Cell Therapy Breakthrough

Publication ID: 24-11856927_0007_PTD
Published: October 26, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Immune Response Innovation: Chimeric Cell Therapy Breakthrough,” Published Technical Disclosure No. 24-11856927_0007_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856927_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,927.

Background and Problem Solved

The original patent addressed the challenge of immune response and inflammation in chimeric animals. However, its scope was limited to treating and preventing these responses in the context of chimeric animal development. This invention builds upon the original patent's core technology to expand its applicability to diverse biomedical fields, thereby solving the problem of limited translational potential.

Novelty and Inventive Step

The novelty of this invention lies in the application of the original patent's core technology to entirely new fields, thereby expanding its translational potential. The inventive step is the recognition that the chimeric animal models can be adapted to address specific biomedical challenges, and the development of novel methods and systems to achieve this.

Alternative Embodiments and Variations

Alternative embodiments of this invention could include the use of different types of stem cells, varying the timing and dosage of the treatment regimen, or incorporating additional components to enhance the chimeric animal model's functionality. Variations could also involve the development of chimeric animal models for other biomedical applications not explicitly mentioned in the new claims.

Potential Commercial Applications and Market

The commercial potential of this invention is vast, with potential applications in the fields of organ transplantation, cancer therapy, autoimmune disorder treatment, biomaterials, and tissue regeneration. The target market includes pharmaceutical and biotechnology companies, research institutions, and hospitals.

CPC Classifications

SectionClassGroup
A A01 A01K67/0271
A A61 A61K31/573
A A61 A61P37/06
A A01 A01K2217/05
A A01 A01K2217/075
A A01 A01K2227/105
A A01 A01K2267/035
C C12 C12N15/09

Original Patent Information

Patent NumberUS 11,856,927
TitleFinding and treatment of inflammation after birth in chimeric animal
Assignee(s)The University of Tokyo