Chimeric Animal Immune Response Innovation

Publication ID: 24-11856927_0009_PTD
Published: October 26, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Chimeric Animal Immune Response Innovation,” Published Technical Disclosure No. 24-11856927_0009_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856927_0009_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,927.

Background and Problem Solved

The original patent disclosed methods for obtaining adult individuals from xenogeneic or allogeneic chimeric animal fetuses, but it did not address the specific challenges of immune response and inflammation in unique operational environments. The present invention fills this gap by providing specialized solutions for high-security research, disaster relief, and extreme weather conditions.

Novelty and Inventive Step

The new claims provide a novel and non-obvious solution by adapting the original patent's methods and compositions for specialized applications in high-security facilities, disaster relief scenarios, and extreme weather conditions. The inventive step lies in the recognition of the need for tailored solutions for these unique environments and the development of specific formulations, systems, and methods to address them.

Alternative Embodiments and Variations

Alternative embodiments of the invention could include the use of different types of chimeric animals, such as those with genetic modifications or induced pluripotent stem cells. Variations of the composition and system could include different formulations of the anti-inflammatory agent or immunosuppressive agent, or the use of additional components to enhance their efficacy. Other operational environments, such as space exploration or high-altitude research, could also be targeted by adapting the invention's components and methods.

Potential Commercial Applications and Market

The invention has significant commercial potential in the fields of biotechnology, pharmaceuticals, and life sciences. The high-security research market, disaster relief industry, and extreme weather condition applications could benefit from the invention's specialized solutions. Additionally, the invention could have implications for human health and disease research, as well as veterinary medicine.

CPC Classifications

SectionClassGroup
A A01 A01K67/0271
A A61 A61K31/573
A A61 A61P37/06
A A01 A01K2217/05
A A01 A01K2217/075
A A01 A01K2227/105
A A01 A01K2267/035
C C12 C12N15/09

Field of Art

Veterinary biotechnology and immunological research, focusing on chimeric animal models, stem cell manipulation, and immunological intervention techniques

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degrees in veterinary science or molecular biology, experienced in stem cell techniques, animal model development, and immunological intervention strategies, familiar with genetic chimera creation and immunosuppressive protocols

Obviousness Rationale

A person skilled in the art would recognize that the PTD's variations represent predictable extensions of the source patent's core methodology by applying the established chimeric animal inflammation management technique to specialized environmental contexts. The fundamental scientific principles of immune response modulation and chimeric animal development remain consistent across the disclosed scenarios. The PTD's claims represent logical adaptations of the original patent's core technological framework to novel operational environments.

Obvious Combinations & Variations

Source Patent Element
Method for obtaining an adult individual from a xenogeneic chimeric animal fetus with no substantial inflammation
PTD Variation
Adapting the method for high-security facility research environments
Obviousness Reasoning
Modifying research protocols for controlled environments represents a routine design choice for a skilled researcher, involving predictable application of existing immunological intervention techniques
Source Patent Element
Anti-inflammatory and immunosuppressive agent administration before immune response occurrence
PTD Variation
Formulating agents to withstand extreme weather conditions in disaster relief scenarios
Obviousness Reasoning
Developing environment-resistant formulations is a standard engineering optimization process involving known pharmaceutical stabilization techniques
Source Patent Element
Chimeric animal fetus with immunodeficient characteristics
PTD Variation
Introducing sensor and communication modules for remote inflammation monitoring
Obviousness Reasoning
Integrating monitoring technologies with existing immunological research models represents an obvious technological enhancement using standard biomedical instrumentation approaches
Source Patent Element
Allogeneic or xenogeneic pluripotent stem cell transplantation method
PTD Variation
Utilizing blastocyst-complemented chimeric animal models in specialized research contexts
Obviousness Reasoning
Expanding research model applications through targeted cell manipulation is a predictable scientific progression within established stem cell research methodologies
35 U.S.C. § 103 Summary: Under 35 U.S.C. ยง 103, the variations disclosed in this publication would be considered obvious extensions of US Patent 11856927, as they represent predictable technological adaptations applying known chimeric animal inflammation management techniques to specialized environmental and research contexts, thereby rendering potential derivative claims non-patentable.

Original Patent Information

Patent NumberUS 11,856,927
TitleFinding and treatment of inflammation after birth in chimeric animal
Assignee(s)The University of Tokyo