Advanced Lung Preservation Solution for Organ Transplant

Publication ID: 24-11856944_0001_PTD
Published: October 26, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Advanced Lung Preservation Solution for Organ Transplant,” Published Technical Disclosure No. 24-11856944_0001_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856944_0001_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,944.

Background and Problem Solved

Current organ preservation techniques, such as hypothermic storage, have limitations in maintaining optimal lung function and viability. The original patent addressed these limitations with a perfusion solution for ex-vivo organ care. However, there remains a need for further improvements to enhance lung preservation and functionality. The present invention addresses these limitations by introducing novel perfusion solution compositions, optimized perfusion conditions, and advanced monitoring systems.

Novelty and Inventive Step

The present invention introduces novel and non-obvious improvements over the original patent, including the optimized perfusion solution composition, advanced monitoring systems, and optimized perfusion conditions. These improvements enhance lung viability and functionality, providing a significant advancement in the field of ex-vivo organ care.

Alternative Embodiments and Variations

Alternative embodiments of the invention could include varying the perfusion solution composition, adjusting the temperature range, or modifying the monitoring system to accommodate different types of organs or perfusion protocols. Additionally, the invention could be adapted for use in other areas of organ care, such as kidney or liver preservation.

Potential Commercial Applications and Market

The enhanced organ care solution has significant commercial potential in the field of organ transplantation, particularly in the preservation and transportation of donor lungs. The invention could be marketed to organ procurement organizations, hospitals, and research institutions, providing a valuable tool for improving lung viability and functionality.

CPC Classifications

SectionClassGroup
A A01 A01N1/0226
A A01 A01N1/0247

Original Patent Information

Patent NumberUS 11,856,944
TitleOrgan care solution for ex-vivo machine perfusion of donor lungs
Assignee(s)TRANSMEDICS, INC.