Published Technical Disclosure Archive

Advanced Lung Preservation Solution for Organ Transplant

Publication ID: 24-11856944_0001_PTD
Published: October 26, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Advanced Lung Preservation Solution for Organ Transplant,” Published Technical Disclosure No. 24-11856944_0001_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856944_0001_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,944.

Background and Problem Solved

Current organ preservation techniques, such as hypothermic storage, have limitations in maintaining optimal lung function and viability. The original patent addressed these limitations with a perfusion solution for ex-vivo organ care. However, there remains a need for further improvements to enhance lung preservation and functionality. The present invention addresses these limitations by introducing novel perfusion solution compositions, optimized perfusion conditions, and advanced monitoring systems.

Novelty and Inventive Step

The present invention introduces novel and non-obvious improvements over the original patent, including the optimized perfusion solution composition, advanced monitoring systems, and optimized perfusion conditions. These improvements enhance lung viability and functionality, providing a significant advancement in the field of ex-vivo organ care.

Alternative Embodiments and Variations

Alternative embodiments of the invention could include varying the perfusion solution composition, adjusting the temperature range, or modifying the monitoring system to accommodate different types of organs or perfusion protocols. Additionally, the invention could be adapted for use in other areas of organ care, such as kidney or liver preservation.

Potential Commercial Applications and Market

The enhanced organ care solution has significant commercial potential in the field of organ transplantation, particularly in the preservation and transportation of donor lungs. The invention could be marketed to organ procurement organizations, hospitals, and research institutions, providing a valuable tool for improving lung viability and functionality.

CPC Classifications

SectionClassGroup
A A01 A01N1/0226
A A01 A01N1/0247

Field of Art

Biomedical engineering, specifically organ preservation techniques and ex-vivo organ perfusion systems, with expertise in solution composition, temperature control, and physiological monitoring

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical researcher with advanced degrees in bioengineering, biochemistry, or medical sciences, possessing knowledge of organ preservation techniques, perfusion system design, and metabolic monitoring

Obviousness Rationale

A person of ordinary skill would recognize that the PTD's variations represent predictable extensions of the source patent's core teachings, involving routine optimization of perfusion parameters, solution composition, and monitoring techniques that are well-established in the field of organ preservation and ex-vivo care systems.

Obvious Combinations & Variations

Source Patent Element
Perfusion solution with specific nutrient and colloid composition at physiologic conditions
PTD Variation
Expanding temperature range to 25-37°C and adding precise oxygen content monitoring
Obviousness Reasoning
Temperature optimization and metabolic monitoring are standard engineering design choices for improving organ preservation, representing predictable variations within known physiological parameters
Source Patent Element
Basic perfusion solution with nutrients, colloids, and hormones
PTD Variation
Adding supplemental antioxidants to reduce oxidative stress
Obviousness Reasoning
Incorporating antioxidants is a known technique for mitigating cellular damage during organ preservation, representing a finite and predictable solution to a recognized problem in the field
Source Patent Element
Lung perfusion method using whole blood or red blood cells
PTD Variation
Implementing advanced sensor array for real-time lung function monitoring
Obviousness Reasoning
Developing comprehensive monitoring systems is a natural progression in medical device technology, representing an obvious enhancement to existing perfusion methodologies
Source Patent Element
Perfusion solution with specific chemical composition
PTD Variation
Precise pH buffering system to maintain 7.35-7.45 range
Obviousness Reasoning
pH control is a fundamental requirement in physiological systems, and developing precise buffering mechanisms represents a routine engineering optimization
Source Patent Element
Ex-vivo lung perfusion method
PTD Variation
Adjusting perfusion flow rates between 0.5-2.5 liters per minute
Obviousness Reasoning
Flow rate optimization is a standard engineering approach to improving organ preservation, representing a predictable variation within known physiological parameters
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11856944, a person having ordinary skill in the art would find the variations disclosed in the present publication to be obvious extensions of the prior art, representing routine engineering optimizations and predictable variations that would be apparent to a skilled practitioner in organ preservation techniques. The disclosed improvements constitute prima facie obviousness under 35 U.S.C. § 103, rendering potential claims to these variations unpatentable.

Original Patent Information

Patent NumberUS 11,856,944
TitleOrgan care solution for ex-vivo machine perfusion of donor lungs
Assignee(s)TRANSMEDICS, INC.