Published Technical Disclosure Archive

Advanced Organ Preservation: Machine Perfusion Tech

Publication ID: 24-11856944_0002_PTD
Published: October 26, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Advanced Organ Preservation: Machine Perfusion Tech,” Published Technical Disclosure No. 24-11856944_0002_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856944_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,944.

Background and Problem Solved

Current organ preservation techniques are limited to hypothermic storage, which can lead to organ damage and reduced viability. The original patent addressed this limitation for lungs, but other organs still rely on outdated preservation methods. This invention solves this problem by adapting the machine perfusion technology to support the preservation of multiple organs.

Novelty and Inventive Step

The new claims introduce a novel application of the original patent's technology to multiple organs, demonstrating an inventive step in the field of organ preservation. The adaptation of the perfusion solution and organ care system to accommodate various organs constitutes a non-obvious extension of the original patent.

Alternative Embodiments and Variations

Alternative embodiments may include the use of different perfusion solutions, tailored to specific organs or disease conditions. Variations may include the integration of additional components, such as sensors or monitoring systems, to enhance the organ care system's functionality.

Potential Commercial Applications and Market

The invention has significant commercial potential in the organ transplantation market, enabling the preservation and transportation of multiple organs for transplantation. The target industries include organ procurement organizations, transplantation centers, and pharmaceutical companies involved in organ preservation solutions.

CPC Classifications

SectionClassGroup
A A01 A01N1/0226
A A01 A01N1/0247

Field of Art

Biomedical engineering and organ preservation techniques, specifically ex-vivo organ maintenance systems with a focus on perfusion solutions for transplantable organs

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical researcher with expertise in organ transplantation, perfusion technologies, and biochemical preservation techniques, holding advanced degrees in biomedical engineering, medicine, or related fields with practical experience in organ preservation methodologies

Obviousness Rationale

A PHOSITA would recognize that the fundamental perfusion solution composition and organ care system disclosed in the source patent can be readily adapted to multiple organ types by making predictable modifications to concentration, specific nutrients, and perfusion parameters. The core technological principles of maintaining organ viability through controlled perfusion are universally applicable across different organ systems, making the extension to kidney, liver, heart, pancreas, and skin graft preservation an obvious technical variation.

Obvious Combinations & Variations

Source Patent Element
Perfusion solution containing nutrients, colloids, buffers, and magnesium sulfate for lung preservation
PTD Variation
Applying identical perfusion solution composition to kidney preservation with minor concentration adjustments
Obviousness Reasoning
Known technique of adapting preservation solutions across organ types with predictable biochemical modifications
Source Patent Element
Ex-vivo organ care system maintaining physiologic conditions
PTD Variation
Extending system functionality to multiple organ types including liver, heart, pancreas, and skin grafts
Obviousness Reasoning
Predictable engineering adaptation of a generalized organ maintenance platform with known technological principles
Source Patent Element
Method of flushing donor organ with nutrient-rich perfusion solution
PTD Variation
Implementing identical flushing methodology across different organ preservation scenarios
Obviousness Reasoning
Finite set of known preservation techniques applicable universally with minor organ-specific refinements
Source Patent Element
Mixing perfusion liquid with whole blood or red blood cells
PTD Variation
Extending blood integration technique to preservation of additional organ types
Obviousness Reasoning
Well-established preservation technique with predictable biochemical interactions across organ systems
Source Patent Element
Physiologic condition maintenance during organ transportation
PTD Variation
Applying consistent metabolic equilibrium principles to diverse organ preservation scenarios
Obviousness Reasoning
Fundamental preservation strategy with broad applicability across different tissue types
35 U.S.C. § 103 Summary: Based on US Patent 11856944, the disclosed variations in organ preservation techniques represent obvious extensions of known ex-vivo perfusion methodologies, wherein a person having ordinary skill in the art would recognize the straightforward adaptability of the core technological approach to multiple organ systems through predictable biochemical and engineering modifications.

Original Patent Information

Patent NumberUS 11,856,944
TitleOrgan care solution for ex-vivo machine perfusion of donor lungs
Assignee(s)TRANSMEDICS, INC.