Advanced Lung Preservation Tech for Organ Transplantation

Publication ID: 24-11856944_0004_PTD

Published: October 26, 2025

Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Advanced Lung Preservation Tech for Organ Transplantation,” Published Technical Disclosure No. 24-11856944_0004_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856944_0004_PTD

This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,944.

Background and Problem Solved

Current organ preservation techniques are limited in their ability to adapt to diverse environmental conditions, resulting in suboptimal lung function and reduced transplant success rates. This invention addresses these limitations by providing specialized organ care solutions tailored to specific operational environments, ensuring optimal lung function and improved transplant outcomes.

Novelty and Inventive Step

The invention's novelty lies in its specialized solutions for extreme environments, which depart from the traditional one-size-fits-all approach to organ care. The inventive step resides in the tailored design of perfusion liquids and OCS configurations, which address the specific challenges of each environment and provide improved lung function and transplant outcomes.

Alternative Embodiments and Variations

Alternative embodiments of the invention may include additional specialized solutions for other extreme environments, such as tropical or desert settings. Variations may also include modifications to the perfusion liquids and OCS configurations to accommodate different types of organs or specific medical conditions.

Potential Commercial Applications and Market

The invention has significant commercial potential in the organ transplantation industry, particularly in regions prone to natural disasters, high-altitude areas, or areas with extreme weather conditions. The specialized solutions may also appeal to military and government agencies, as well as organizations involved in disaster relief and humanitarian efforts.

CPC Classifications

Section	Class	Group
A	A01	A01N1/0226
A	A01	A01N1/0247

Section 103 Obviousness Analysis (PHOSITA)

▼

Field of Art

Biomedical engineering, specifically organ preservation and ex-vivo perfusion systems, with expertise in medical device design, physiological solution composition, and organ transportation technologies

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device specialist with advanced degrees in bioengineering, experience in organ preservation techniques, knowledge of physiological parameters, and understanding of perfusion system design and environmental adaptation strategies

Obviousness Rationale

A PHOSITA would recognize that the source patent's fundamental organ perfusion methodology provides a flexible framework for environmental adaptation. The disclosed variations represent predictable extensions of known organ preservation principles, applying standard engineering design techniques to address specific environmental challenges while maintaining core perfusion system principles.

Obvious Combinations & Variations

Source Patent Element

Perfusion solution with specific nutrient, colloid, and chemical composition for maintaining lung physiologic conditions

PTD Variation

Specialized perfusion solutions adapted for high-altitude, extreme cold, and remote environments with modified chemical compositions

Obviousness Reasoning

A PHOSITA would understand that adjusting perfusion solution chemistry to accommodate environmental variables is a routine engineering design optimization with predictable results

Source Patent Element

Ex-vivo lung preservation method using machine perfusion at near-physiologic conditions

PTD Variation

Portable, battery-powered and solar-powered OCS systems for disaster relief and remote environment lung transportation

Obviousness Reasoning

Modifying power sources and adding portability represents an obvious technological adaptation using known engineering techniques for medical device miniaturization

Source Patent Element

Perfusion liquid mixing with whole blood or red blood cells

PTD Variation

Adding GPS tracking, biometric authentication, and satellite communication to OCS perfusion systems

Obviousness Reasoning

Integrating standard tracking and security technologies into medical transportation systems is a predictable enhancement using known technological solutions

Source Patent Element

Method of flushing donor lung with multi-component perfusion solution

PTD Variation

Developing specialized solutions with cryoprotectants and antifreeze agents for extreme temperature environments

Obviousness Reasoning

Modifying perfusion solution chemistry to address temperature challenges is a standard engineering approach with predictable scientific methodology

Source Patent Element

Organ care system maintaining physiologic conditions during preservation

PTD Variation

Remote monitoring of lung function during transportation using satellite communication technologies

Obviousness Reasoning

Implementing telemetry and remote monitoring represents an obvious technological extension using standard communication and sensor integration techniques

35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11856944, a person having ordinary skill in the art would find the disclosed variations in organ preservation and transportation technologies to be obvious modifications of the fundamental ex-vivo lung perfusion methodology. The proposed technical solutions represent predictable engineering adaptations that would be readily conceived by a skilled practitioner without requiring inventive insight beyond the scope of ordinary professional capabilities.

Original Patent Information

Patent Number	US 11,856,944
Title	Organ care solution for ex-vivo machine perfusion of donor lungs
Assignee(s)	TRANSMEDICS, INC.