Advanced Lung Preservation Solution for Organ Transplant

Publication ID: 24-11856944_0006_PTD
Published: October 26, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Advanced Lung Preservation Solution for Organ Transplant,” Published Technical Disclosure No. 24-11856944_0006_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856944_0006_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,944.

Background and Problem Solved

Current organ preservation techniques, such as those described in the original patent, have limitations including oxidative stress, inefficient perfusion, and inadequate oxygenation. This invention addresses these limitations by introducing novel components and adjustments to the perfusion solution and system, enabling more efficient and effective ex-vivo lung perfusion.

Novelty and Inventive Step

The invention's novelty lies in the combination of novel antioxidant components, real-time perfusion liquid adjustments, modified colloid components, and advanced gas exchange modules, which collectively provide a significant improvement over the original patent. The inventive step is the integration of these components to create a more efficient, effective, and viable ex-vivo lung perfusion system.

Alternative Embodiments and Variations

Alternative embodiments may include variations in the antioxidant component, colloid composition, or gas exchange module design. Additionally, the system could be adapted for perfusion of other organs, such as the heart or liver, or integrated with other organ preservation technologies.

Potential Commercial Applications and Market

The enhanced organ care solution has significant commercial potential in the organ transplantation market, addressing the need for improved lung preservation and transplantation outcomes. The invention could be marketed to organ procurement organizations, transplantation centers, and pharmaceutical companies, with potential applications in human transplantation and potentially in veterinary medicine.

CPC Classifications

SectionClassGroup
A A01 A01N1/0226
A A01 A01N1/0247

Original Patent Information

Patent NumberUS 11,856,944
TitleOrgan care solution for ex-vivo machine perfusion of donor lungs
Assignee(s)TRANSMEDICS, INC.