Published Technical Disclosure Archive

Advanced Lung Preservation Tech for Organ Transplantation

Publication ID: 24-11856944_0008_PTD
Published: October 26, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Advanced Lung Preservation Tech for Organ Transplantation,” Published Technical Disclosure No. 24-11856944_0008_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856944_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,944.

Background and Problem Solved

Current organ preservation techniques, as described in the original patent, are limited by their inability to provide real-time monitoring and adaptation to changing lung conditions. This invention addresses these limitations by integrating advanced technologies to ensure optimal lung care and transplantation outcomes.

Novelty and Inventive Step

The invention's novelty lies in the synergistic integration of AI, IoT, and blockchain technologies with an organ care system to provide real-time monitoring, adaptation, and optimization of ex-vivo lung care. This integration enables a more efficient, secure, and effective transplantation process, which is not obvious from the original patent.

Alternative Embodiments and Variations

Alternative embodiments include using different AI algorithms, IoT sensors, or blockchain platforms. Variations may include integrating the system with other medical devices or using different perfusion solutions. These alternatives ensure broad conceptual coverage and adaptability to different implementation scenarios.

Potential Commercial Applications and Market

The invention has significant commercial potential in the organ transplantation market, with potential applications in hospitals, research institutions, and pharmaceutical companies. The market for ex-vivo lung care and transplantation is growing, and this invention can provide a competitive edge to companies operating in this space.

CPC Classifications

SectionClassGroup
A A01 A01N1/0226
A A01 A01N1/0247

Field of Art

Biomedical engineering, specifically organ preservation and ex-vivo perfusion technologies with a focus on lung transplantation and medical device systems

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device specialist with expertise in organ preservation techniques, perfusion solutions, medical monitoring systems, and interdisciplinary medical technology integration

Obviousness Rationale

A PHOSITA would recognize that integrating digital technologies like AI, IoT, and blockchain with existing organ preservation systems represents a natural evolutionary progression in medical technology. The fundamental organ care principles from the source patent provide a clear technical foundation for incorporating advanced monitoring and optimization technologies. The proposed variations represent predictable applications of known technological integration strategies to an established medical preservation methodology.

Obvious Combinations & Variations

Source Patent Element
Perfusion solution with specific nutrient, colloid, and buffer compositions for ex-vivo lung preservation
PTD Variation
Adding IoT-enabled sensors to monitor and dynamically adjust perfusion solution parameters in real-time
Obviousness Reasoning
Integrating real-time monitoring sensors is a known technique in medical device technologies, representing a predictable enhancement to existing preservation methods
Source Patent Element
Method of flushing donor lungs with a complex perfusion liquid
PTD Variation
Implementing AI-powered algorithms to analyze and optimize perfusion parameters based on lung function data
Obviousness Reasoning
Applying machine learning to medical monitoring represents a standard approach for improving diagnostic and treatment precision in biomedical engineering
Source Patent Element
Ex-vivo organ care system for lung preservation
PTD Variation
Integrating blockchain-based tracking platform to ensure secure documentation and transparent organ transfer processes
Obviousness Reasoning
Blockchain technology is a recognized method for enhancing data security and traceability in medical technology systems
Source Patent Element
Perfusion method involving mixing solutions with whole blood or red blood cells
PTD Variation
Developing AI-driven donor-recipient compatibility matching algorithms
Obviousness Reasoning
Computational matching of biological systems is a predictable application of machine learning in medical transplantation technologies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11856944 and the disclosed technological variations, a person of ordinary skill in the art would find the integration of AI, IoT, and blockchain technologies with ex-vivo organ preservation systems to be an obvious extension of existing medical device methodologies, thereby rendering potential claims to such technologies anticipated and non-patentable under 35 U.S.C. Section 103.

Original Patent Information

Patent NumberUS 11,856,944
TitleOrgan care solution for ex-vivo machine perfusion of donor lungs
Assignee(s)TRANSMEDICS, INC.