Advanced Lung Perfusion for Extreme Environments

Publication ID: 24-11856944_0009_PTD
Published: October 27, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Advanced Lung Perfusion for Extreme Environments,” Published Technical Disclosure No. 24-11856944_0009_PTD, Published October 27, 2025, available at https://archive.pr1or.art/24-11856944_0009_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,944.

Background and Problem Solved

Current ex-vivo lung perfusion solutions are limited in their ability to operate effectively in non-standard environments. The original patent disclosed a perfusion solution for machine perfusion of donor lungs at physiologic or near-physiologic conditions. However, these solutions are not optimized for unique operational environments, such as high-altitude, disaster relief, high-security, extreme cold, and remote areas. This invention addresses these limitations by providing specialized solutions that can maintain a lung at or near normal physiologic conditions in these niche environments.

Novelty and Inventive Step

The new claims provide a novel and non-obvious solution by adapting the original perfusion solution for specific, niche operational environments. The inventive step lies in the modification of the solution's composition and packaging to accommodate the unique challenges of each environment.

Alternative Embodiments and Variations

Alternative embodiments of the invention could include additional specialized solutions for other niche environments, such as tropical or desert environments. Variations could also include different packaging options or modifications to the solution's composition to accommodate specific environmental factors.

Potential Commercial Applications and Market

The invention has significant commercial potential in the organ transplantation and disaster relief industries, particularly in regions with unique environmental challenges. The specialized solutions could be marketed to hospitals, research institutions, and disaster relief organizations operating in these environments.

CPC Classifications

SectionClassGroup
A A01 A01N1/0226
A A01 A01N1/0247

Original Patent Information

Patent NumberUS 11,856,944
TitleOrgan care solution for ex-vivo machine perfusion of donor lungs
Assignee(s)TRANSMEDICS, INC.