Published Technical Disclosure Archive

Advanced Lung Perfusion for Extreme Environments

Publication ID: 24-11856944_0009_PTD
Published: October 27, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Advanced Lung Perfusion for Extreme Environments,” Published Technical Disclosure No. 24-11856944_0009_PTD, Published October 27, 2025, available at https://archive.pr1or.art/24-11856944_0009_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,944.

Background and Problem Solved

Current ex-vivo lung perfusion solutions are limited in their ability to operate effectively in non-standard environments. The original patent disclosed a perfusion solution for machine perfusion of donor lungs at physiologic or near-physiologic conditions. However, these solutions are not optimized for unique operational environments, such as high-altitude, disaster relief, high-security, extreme cold, and remote areas. This invention addresses these limitations by providing specialized solutions that can maintain a lung at or near normal physiologic conditions in these niche environments.

Novelty and Inventive Step

The new claims provide a novel and non-obvious solution by adapting the original perfusion solution for specific, niche operational environments. The inventive step lies in the modification of the solution's composition and packaging to accommodate the unique challenges of each environment.

Alternative Embodiments and Variations

Alternative embodiments of the invention could include additional specialized solutions for other niche environments, such as tropical or desert environments. Variations could also include different packaging options or modifications to the solution's composition to accommodate specific environmental factors.

Potential Commercial Applications and Market

The invention has significant commercial potential in the organ transplantation and disaster relief industries, particularly in regions with unique environmental challenges. The specialized solutions could be marketed to hospitals, research institutions, and disaster relief organizations operating in these environments.

CPC Classifications

SectionClassGroup
A A01 A01N1/0226
A A01 A01N1/0247

Field of Art

Organ preservation and ex-vivo organ care systems, specifically focusing on lung perfusion techniques with expertise in biochemical solution composition, medical device design, and organ transportation protocols

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical researcher with advanced training in organ preservation, experience with perfusion solutions, understanding of physiological parameters, and knowledge of organ transportation challenges

Obviousness Rationale

A PHOSITA would recognize that the source patent's lung perfusion solution provides a foundational framework that can be systematically adapted for specialized environmental conditions. The core perfusion chemistry and organ maintenance principles remain consistent across the disclosed variations, with modifications representing predictable engineering adaptations. The PTD's claims represent logical extensions of the original patent's core technological approach, utilizing known techniques for solution modification and organ care system design.

Obvious Combinations & Variations

Source Patent Element
Perfusion solution with specific nutrient, colloid, and chemical composition for maintaining lung viability
PTD Variation
Modifying solution oxygen content and chemical balance for high-altitude environments
Obviousness Reasoning
A PHOSITA would recognize that adjusting solution chemistry to compensate for atmospheric pressure variations is a standard engineering design choice with predictable outcomes
Source Patent Element
Lung OCS system designed for maintaining physiologic conditions during transportation
PTD Variation
Portable OCS solution for disaster relief scenarios with extended transportation requirements
Obviousness Reasoning
Adapting organ preservation techniques for emergency medical contexts represents a foreseeable application of existing preservation technology
Source Patent Element
Perfusion solution with temperature-sensitive chemical components
PTD Variation
Solution modified to maintain lung viability in extreme cold environments
Obviousness Reasoning
Adjusting solution composition to maintain organ stability across temperature ranges is a known technique in organ preservation engineering
Source Patent Element
Lung perfusion method involving specific chemical interactions and preservation protocols
PTD Variation
Tamper-resistant packaging and remote monitoring capabilities for high-security organ transportation
Obviousness Reasoning
Implementing security and tracking features represents an obvious technological enhancement to existing organ preservation systems
Source Patent Element
Complex perfusion solution with multiple chemical components
PTD Variation
Satellite-enabled monitoring system for remote lung transportation
Obviousness Reasoning
Integrating telecommunications and tracking technology with existing organ preservation protocols is a predictable technological evolution
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11856944, the disclosed variations in lung perfusion solution design and organ care system configuration would be considered obvious to a Person Having Ordinary Skill In The Art. The PTD demonstrates that the source patent's fundamental technological approach can be systematically adapted for specialized environmental and operational contexts through routine engineering modifications, thereby rendering potential derivative claims non-patentable under 35 U.S.C. Section 103.

Original Patent Information

Patent NumberUS 11,856,944
TitleOrgan care solution for ex-vivo machine perfusion of donor lungs
Assignee(s)TRANSMEDICS, INC.