Published Technical Disclosure Archive

Advanced MOF Biospecimen Preservation Technology

Publication ID: 24-11856945_0001_PTD
Published: October 26, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Advanced MOF Biospecimen Preservation Technology,” Published Technical Disclosure No. 24-11856945_0001_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856945_0001_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,945.

Background and Problem Solved

The original patent disclosed methods and systems for preparing and preserving biological samples using metal-organic framework (MOF) encapsulants. However, the existing technology has inherent limitations, including poor thermal stability and lack of control over biomarker preservation. The present invention addresses these limitations by introducing novel MOF encapsulants with improved thermal stability, nanoporous materials with controlled release mechanisms, and integrated temperature monitoring and control systems.

Novelty and Inventive Step

The present invention's novelty lies in the introduction of improved thermal stability, controlled release mechanisms, and customized preservation conditions, which overcome the limitations of the original patent. The inventive step is the combination of these features, which provides a significant advancement in the field of biological sample preservation.

Alternative Embodiments and Variations

Alternative embodiments of the invention include the use of different MOF materials, varying the nanoporous structure, and incorporating additional features such as humidity control and biomarker detection. Variations of the invention may also include different substrates, such as glass or plastic, and alternative desiccant materials.

Potential Commercial Applications and Market

The present invention has significant commercial potential in the biomedical research and clinical diagnosis industries, where high-quality biospecimens are critical. The invention's ability to provide enhanced preservation conditions and controlled release mechanisms can improve the accuracy and reliability of biomarker analysis, leading to better disease diagnosis and treatment outcomes.

CPC Classifications

SectionClassGroup
A A01 A01N1/0231
G G01 G01N1/4044

Field of Art

Biological sample preservation techniques, focusing on molecular encapsulation and stabilization technologies, with expertise in materials science, biochemistry, and analytical chemistry

Person of Ordinary Skill (PHOSITA) Profile

A researcher or technician with advanced degree in chemistry or biochemistry, familiar with metal-organic frameworks (MOFs), protein stabilization techniques, and sample preservation methodologies

Obviousness Rationale

A PHOSITA would recognize that the PTD's variations represent predictable extensions of the source patent's core MOF encapsulation technology. The disclosed modifications involve routine engineering adaptations such as adjusting pore size, incorporating temperature monitoring, and exploring alternative substrate materials. These variations represent standard design choices within the established framework of MOF-based sample preservation techniques.

Obvious Combinations & Variations

Source Patent Element
MOF encapsulant using zeolitic imidazolate framework (ZIF) type materials
PTD Variation
Introducing ZIF-8 specific encapsulant with integrated temperature monitoring
Obviousness Reasoning
Selection of specific ZIF variant and adding monitoring represents predictable optimization within known MOF preservation techniques
Source Patent Element
Precursor formation using 2-methylimidazole and zinc acetate
PTD Variation
Tunable pore size and surface chemistry modifications for protein stabilization
Obviousness Reasoning
Adjusting molecular precursor ratios to modify encapsulant characteristics is a standard materials engineering approach with foreseeable results
Source Patent Element
Water insoluble substrate for sample preservation
PTD Variation
MOF encapsulant-coated paper substrate with integrated desiccant
Obviousness Reasoning
Exploring alternative substrate materials and incorporating desiccant represents routine design variation with predictable preservation outcomes
Source Patent Element
Biological sample preservation method using metal-organic frameworks
PTD Variation
Controlled release mechanism for on-demand biomarker analysis
Obviousness Reasoning
Implementing release mechanisms is a known technique for enhancing sample analysis capabilities within established preservation technologies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11856945, a person having ordinary skill in the art would find the variations disclosed in the present publication to be obvious extensions of the prior art, rendering potential claims directed to these modifications unpatentable under 35 U.S.C. ยง 103 due to the predictable combination of known preservation techniques and routine engineering adaptations.

Original Patent Information

Patent NumberUS 11,856,945
TitleMethods and systems for preparing and preserving a biological sample
Assignee(s)Washington University