Advanced MOF Biospecimen Preservation Technology

Publication ID: 24-11856945_0001_PTD
Published: October 26, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Advanced MOF Biospecimen Preservation Technology,” Published Technical Disclosure No. 24-11856945_0001_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856945_0001_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,945.

Background and Problem Solved

The original patent disclosed methods and systems for preparing and preserving biological samples using metal-organic framework (MOF) encapsulants. However, the existing technology has inherent limitations, including poor thermal stability and lack of control over biomarker preservation. The present invention addresses these limitations by introducing novel MOF encapsulants with improved thermal stability, nanoporous materials with controlled release mechanisms, and integrated temperature monitoring and control systems.

Novelty and Inventive Step

The present invention's novelty lies in the introduction of improved thermal stability, controlled release mechanisms, and customized preservation conditions, which overcome the limitations of the original patent. The inventive step is the combination of these features, which provides a significant advancement in the field of biological sample preservation.

Alternative Embodiments and Variations

Alternative embodiments of the invention include the use of different MOF materials, varying the nanoporous structure, and incorporating additional features such as humidity control and biomarker detection. Variations of the invention may also include different substrates, such as glass or plastic, and alternative desiccant materials.

Potential Commercial Applications and Market

The present invention has significant commercial potential in the biomedical research and clinical diagnosis industries, where high-quality biospecimens are critical. The invention's ability to provide enhanced preservation conditions and controlled release mechanisms can improve the accuracy and reliability of biomarker analysis, leading to better disease diagnosis and treatment outcomes.

CPC Classifications

SectionClassGroup
A A01 A01N1/0231
G G01 G01N1/4044

Original Patent Information

Patent NumberUS 11,856,945
TitleMethods and systems for preparing and preserving a biological sample
Assignee(s)Washington University