Published Technical Disclosure Archive

MOF Biomarker Preservation: Multi-Industry Innovation

Publication ID: 24-11856945_0002_PTD
Published: October 26, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “MOF Biomarker Preservation: Multi-Industry Innovation,” Published Technical Disclosure No. 24-11856945_0002_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856945_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,945.

Background and Problem Solved

The original patent disclosed methods and systems for preparing and preserving biological samples using MOF encapsulants, primarily focused on biomedical research and clinical diagnosis. However, the instability of molecular biomarkers in various biofluids remains a challenge across multiple industries. This invention addresses these limitations by adapting the MOF encapsulant technology to address specific problems in agriculture, food safety, water quality monitoring, vaccine preservation, and air quality monitoring.

Novelty and Inventive Step

The novelty of this invention lies in the adaptation of the MOF encapsulant technology to address specific problems in diverse industries, beyond the original biomedical research and clinical diagnosis applications. The inventive step involves the recognition of the MOF encapsulant's potential in preserving biological samples across multiple industries, and the development of novel systems and methods to achieve this.

Alternative Embodiments and Variations

Alternative embodiments of this invention include the use of different MOF materials, varying the type and ratio of metal ions and organic linkers, and incorporating additional components to enhance the stability and detection capabilities of the biological samples. Variations of the invention may also involve different drying mechanisms, substrates, and sensors to accommodate specific industry requirements.

Potential Commercial Applications and Market

This invention has significant commercial potential across multiple industries, including agriculture, food safety, water quality monitoring, vaccine preservation, and air quality monitoring. The market for MOF-based preservation and detection systems is expected to grow substantially, driven by the increasing demand for efficient and cost-effective solutions in these industries.

CPC Classifications

SectionClassGroup
A A01 A01N1/0231
G G01 G01N1/4044

Field of Art

Biotechnology and materials science, focusing on sample preservation techniques using metal-organic frameworks (MOFs) for biological and environmental applications. Requires expertise in chemical engineering, protein stabilization, and materials characterization

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with advanced degree in chemistry or materials science, familiar with MOF synthesis, protein encapsulation techniques, and cross-industry applications of stabilization technologies

Obviousness Rationale

A person of ordinary skill would recognize the MOF encapsulation technique disclosed in the source patent as a versatile platform technology with broad applicability beyond initial biomedical research. The PTD demonstrates predictable extensions of the core MOF stabilization method to agricultural, food safety, vaccine preservation, and environmental monitoring applications by applying the same fundamental encapsulation principles to different biological systems and detection contexts.

Obvious Combinations & Variations

Source Patent Element
MOF encapsulation method for preserving protein biomarkers in biological samples
PTD Variation
Applying MOF encapsulation to preserve agricultural product proteins and detect food spoilage
Obviousness Reasoning
Known technique of protein stabilization can be predictably extended to different biological matrices with expected preservation of protein structure and function
Source Patent Element
Use of zeolitic imidazolate framework (ZIF) type MOF for sample preservation
PTD Variation
Utilizing ZIF MOFs for vaccine antigen preservation on paper substrates
Obviousness Reasoning
Transferring stabilization technique to vaccine storage represents a straightforward application of known MOF encapsulation principles with predictable results
Source Patent Element
Molar ratios of metal precursors (2-methylimidazole to zinc acetate) for MOF synthesis
PTD Variation
Adapting precursor ratios for environmental monitoring protein sensors
Obviousness Reasoning
Skilled artisan would recognize that adjusting MOF composition is a routine design optimization for different detection applications
Source Patent Element
Preservation of protein biomarkers at ambient temperatures
PTD Variation
Extending preservation technique to water contamination detection and air quality monitoring
Obviousness Reasoning
The fundamental MOF encapsulation mechanism provides a generalizable approach to protein stabilization across diverse environmental sensing contexts
35 U.S.C. § 103 Summary: Based on US Patent 11856945's disclosure of MOF encapsulation for biological sample preservation, the present publication demonstrates that extending such techniques to agricultural, vaccine, environmental monitoring, and food safety applications would have been obvious to a person of ordinary skill in the art at the time of invention, rendering potential claims to such variations anticipated or obvious under 35 U.S.C. ยง 103.

Original Patent Information

Patent NumberUS 11,856,945
TitleMethods and systems for preparing and preserving a biological sample
Assignee(s)Washington University