Published Technical Disclosure Archive

MOF Biospecimen Preservation: Advanced Analytical System

Publication ID: 24-11856945_0003_PTD
Published: October 26, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “MOF Biospecimen Preservation: Advanced Analytical System,” Published Technical Disclosure No. 24-11856945_0003_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856945_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,945.

Background and Problem Solved

The original patent disclosed methods and systems for preparing and preserving biological samples using MOF encapsulants. However, the pre-analytical stage remains a significant bottleneck in biomedical research and clinical diagnosis. The present invention addresses this limitation by synergistically combining MOF technology with other distinct technologies to create more powerful systems for preserving, analyzing, and utilizing biological samples.

Novelty and Inventive Step

The novelty of the present invention lies in the synergistic integration of MOF technology with AI, IoT, blockchain, and machine learning technologies, which creates a new, more powerful system for preserving, analyzing, and utilizing biological samples. The inventive step is the recognition that these distinct technologies can be combined to overcome the limitations of the original patent and provide a more comprehensive solution for biomedical research and clinical diagnosis.

Alternative Embodiments and Variations

Alternative embodiments of the invention could include the use of different types of MOF materials, varying the composition of the preserving agent, or incorporating additional technologies such as robotics or virtual reality. Variations could also include adapting the systems for use in different fields, such as agriculture or environmental monitoring.

Potential Commercial Applications and Market

The invention has significant commercial potential in the biomedical research and clinical diagnosis industries, where the availability of high-quality biospecimens is critical. The market for biospecimen preservation and analysis systems is expected to grow substantially in the coming years, driven by advances in personalized medicine, precision diagnostics, and translational research.

CPC Classifications

SectionClassGroup
A A01 A01N1/0231
G G01 G01N1/4044

Field of Art

Biomedical sample preservation technologies, focusing on molecular encapsulation techniques with expertise in materials science, biochemistry, and analytical instrumentation

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with advanced degrees in chemistry or bioengineering, familiar with metal-organic frameworks (MOFs), protein stabilization techniques, and emerging diagnostic technologies

Obviousness Rationale

A PHOSITA would recognize that integrating digital technologies with MOF-based preservation represents a predictable extension of the source patent's core innovation. The fundamental molecular preservation mechanism remains consistent, while the proposed technological integrations represent standard engineering approaches to enhance sample tracking and analysis. The combination of MOF preservation with AI, blockchain, and IoT represents an obvious implementation of known technologies to solve recognized limitations in biospecimen management.

Obvious Combinations & Variations

Source Patent Element
Metal-organic framework (MOF) encapsulation for biological sample preservation
PTD Variation
AI-powered diagnostic module for analyzing preserved biomarkers
Obviousness Reasoning
Integrating computational analysis with preserved samples is a predictable enhancement, representing a standard approach to extracting maximum value from stabilized biological materials
Source Patent Element
Zeolitic imidazolate framework (ZIF) type MOF for protein stabilization
PTD Variation
Blockchain-based tracking system for sample provenance and monitoring
Obviousness Reasoning
Implementing digital tracking for scientifically valuable specimens is an obvious solution to existing sample management challenges, using well-established distributed ledger technologies
Source Patent Element
Preserving agent composition with specific molar ratios of chemical precursors
PTD Variation
IoT-enabled environmental monitoring sensors for sample storage conditions
Obviousness Reasoning
Extending sample preservation techniques with real-time monitoring represents a logical and predictable technological progression using standard sensor and communication technologies
Source Patent Element
Water insoluble substrate for MOF encapsulation
PTD Variation
Machine learning algorithms for predictive biomarker analysis
Obviousness Reasoning
Applying computational predictive techniques to stabilized biological samples is a straightforward application of emerging data science methodologies to existing preservation technologies
Source Patent Element
Biological sample preservation method using metal-organic frameworks
PTD Variation
Decentralized biospecimen collection platform integrating MOF preservation with secure data management
Obviousness Reasoning
Creating distributed research infrastructure using existing preservation technologies represents an obvious technological evolution addressing known collaboration and data sharing challenges
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11856945 and the disclosed technological variations, a person of ordinary skill in the art would find the proposed combinations of MOF preservation technologies with AI, blockchain, IoT, and machine learning techniques to be obvious extensions of the prior art, lacking the requisite non-obviousness for patent protection under 35 U.S.C. ยง 103.

Original Patent Information

Patent NumberUS 11,856,945
TitleMethods and systems for preparing and preserving a biological sample
Assignee(s)Washington University