Published Technical Disclosure Archive

Advanced MOF Biological Sample Preservation Tech

Publication ID: 24-11856945_0004_PTD
Published: October 26, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Advanced MOF Biological Sample Preservation Tech,” Published Technical Disclosure No. 24-11856945_0004_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856945_0004_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,945.

Background and Problem Solved

The original patent disclosed methods and systems for preparing and preserving biological samples using metal-organic frameworks (MOFs). However, these methods and systems were not adapted for specific, narrow markets or unique operational environments. This invention addresses the limitations of the original patent by providing specialized solutions for preserving biological samples in high-security environments, disaster relief situations, extreme weather conditions, and remote or resource-limited settings.

Novelty and Inventive Step

The novelty of this invention lies in the adaptation of MOF-based biological sample preservation methods and systems for specific, narrow markets or unique operational environments. The inventive step is the combination of MOF encapsulants with specialized containers and substrates designed to address the challenges of high-security environments, disaster relief situations, extreme weather conditions, and remote or resource-limited settings.

Alternative Embodiments and Variations

Alternative embodiments of the invention could include the use of different MOF materials, such as ZIF-7 or MIL-53, or the incorporation of additional components, such as temperature control systems or sensors. Variations of the invention could also include the use of different types of biological samples, such as tissues or cells, or the adaptation of the methods and systems for use in different industries, such as pharmaceuticals or biotechnology.

Potential Commercial Applications and Market

The invention has potential commercial applications in various industries, including biomedical research, clinical diagnosis, pharmaceuticals, and biotechnology. The market for specialized biological sample preservation systems and methods is significant, particularly in areas such as high-security environments, disaster relief situations, and remote or resource-limited settings.

CPC Classifications

SectionClassGroup
A A01 A01N1/0231
G G01 G01N1/4044

Field of Art

Biological sample preservation techniques, with expertise in molecular encapsulation, biomarker stabilization, and material science related to metal-organic frameworks (MOFs)

Person of Ordinary Skill (PHOSITA) Profile

A researcher or technician with advanced degrees in chemistry, biochemistry, or materials science, possessing knowledge of MOF synthesis, biomolecule stabilization techniques, and sample preservation methodologies

Obviousness Rationale

A PHOSITA would recognize that the PTD represents predictable variations of the source patent's core MOF encapsulation technology by adapting the preservation method to specific environmental contexts. The fundamental chemical principles of MOF encapsulation remain consistent, with the PTD merely extending the application through contextual modifications. These variations represent routine engineering adaptations that would be apparent to a skilled practitioner familiar with MOF-based preservation techniques.

Obvious Combinations & Variations

Source Patent Element
MOF encapsulant using zeolitic imidazolate framework (ZIF) type materials
PTD Variation
Specific selection of ZIF-8 for high-security and disaster relief sample preservation
Obviousness Reasoning
Selection of specific MOF subtypes within a known class represents an obvious design choice with predictable stabilization outcomes
Source Patent Element
Preservation method involving contact with MOF precursors
PTD Variation
Incorporation of specialized containers and environmental adaptation strategies
Obviousness Reasoning
Extending preservation technique to specific operational environments is a straightforward technical adaptation using known encapsulation principles
Source Patent Element
Method of preparing biological samples using metal-organic framework encapsulants
PTD Variation
Application to protein biomarker stabilization in extreme temperature conditions
Obviousness Reasoning
Applying established MOF preservation techniques to temperature-sensitive biomarkers represents a predictable extension of the original preservation methodology
Source Patent Element
Use of water insoluble substrate for sample preservation
PTD Variation
Water-resistant substrates designed for disaster relief and extreme weather scenarios
Obviousness Reasoning
Modifying substrate characteristics to enhance environmental resilience is an obvious engineering improvement within the known preservation technique
Source Patent Element
MOF encapsulation using 2-methylimidazole and zinc acetate precursors
PTD Variation
Adaptation of MOF preparation for portable, compact sample storage in resource-limited settings
Obviousness Reasoning
Translating established MOF synthesis techniques to different operational contexts represents a routine technical adaptation
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11856945, the variations disclosed herein would be considered obvious to a person having ordinary skill in the art, as they represent predictable extensions of known MOF-based biological sample preservation techniques through routine engineering modifications that do not rise to the level of non-obvious innovation.

Original Patent Information

Patent NumberUS 11,856,945
TitleMethods and systems for preparing and preserving a biological sample
Assignee(s)Washington University