Smart MOF Biospecimen Preservation & Monitoring Tech

Publication ID: 24-11856945_0005_PTD
Published: October 26, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Smart MOF Biospecimen Preservation & Monitoring Tech,” Published Technical Disclosure No. 24-11856945_0005_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856945_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,945.

Background and Problem Solved

The original patent disclosed methods and systems for preparing and preserving biological samples using MOF encapsulation. However, the existing approach has limitations, including the need for controlled temperature storage and lack of real-time monitoring capabilities. The present invention addresses these limitations by introducing a smart container with integrated MOF encapsulation and real-time biomarker stability monitoring, enabling long-term preservation of biological samples at ambient temperatures.

Novelty and Inventive Step

The present invention's novelty lies in the integration of advanced MOF encapsulation, real-time biomarker stability monitoring, and cloud-based data analytics to enable long-term preservation of high-quality biological samples at ambient temperatures. The inventive step is the combination of these components to create a smart biospecimen preservation and management system, which is not obvious from the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the invention include the use of different MOF materials, varying the design of the smart container, and incorporating additional sensors for monitoring other sample parameters. Variations of the portable biospecimen collection kit may include different substrates, such as paper or fabric, and alternative drying apparatuses.

Potential Commercial Applications and Market

The present invention has significant commercial potential in the biomedical research and clinical diagnostics industries, enabling the preservation and management of high-quality biological samples for extended periods. The target market includes research institutions, hospitals, and pharmaceutical companies, with potential applications in personalized medicine, biomarker discovery, and disease diagnosis.

CPC Classifications

SectionClassGroup
A A01 A01N1/0231
G G01 G01N1/4044

Original Patent Information

Patent NumberUS 11,856,945
TitleMethods and systems for preparing and preserving a biological sample
Assignee(s)Washington University