Smart MOF Biospecimen Preservation & Monitoring Tech

Publication ID: 24-11856945_0005_PTD

Published: October 26, 2025

Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Smart MOF Biospecimen Preservation & Monitoring Tech,” Published Technical Disclosure No. 24-11856945_0005_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856945_0005_PTD

This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,945.

Background and Problem Solved

The original patent disclosed methods and systems for preparing and preserving biological samples using MOF encapsulation. However, the existing approach has limitations, including the need for controlled temperature storage and lack of real-time monitoring capabilities. The present invention addresses these limitations by introducing a smart container with integrated MOF encapsulation and real-time biomarker stability monitoring, enabling long-term preservation of biological samples at ambient temperatures.

Novelty and Inventive Step

The present invention's novelty lies in the integration of advanced MOF encapsulation, real-time biomarker stability monitoring, and cloud-based data analytics to enable long-term preservation of high-quality biological samples at ambient temperatures. The inventive step is the combination of these components to create a smart biospecimen preservation and management system, which is not obvious from the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the invention include the use of different MOF materials, varying the design of the smart container, and incorporating additional sensors for monitoring other sample parameters. Variations of the portable biospecimen collection kit may include different substrates, such as paper or fabric, and alternative drying apparatuses.

Potential Commercial Applications and Market

The present invention has significant commercial potential in the biomedical research and clinical diagnostics industries, enabling the preservation and management of high-quality biological samples for extended periods. The target market includes research institutions, hospitals, and pharmaceutical companies, with potential applications in personalized medicine, biomarker discovery, and disease diagnosis.

CPC Classifications

Section	Class	Group
A	A01	A01N1/0231
G	G01	G01N1/4044

Section 103 Obviousness Analysis (PHOSITA)

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Field of Art

Biological sample preservation techniques, with expertise in metal-organic framework (MOF) encapsulation, biomarker stabilization, and diagnostic sample processing

Person of Ordinary Skill (PHOSITA) Profile

A researcher or engineer with advanced degrees in chemistry, biotechnology, or materials science, possessing knowledge of sample preservation techniques, MOF synthesis, and diagnostic technologies

Obviousness Rationale

A person having ordinary skill in the art would recognize that the PTD's variations represent predictable extensions of the source patent's MOF encapsulation method. The additional elements of real-time monitoring, cloud-based analytics, and portable collection systems are logical technological improvements that would be obvious to implement using known techniques in biospecimen preservation and diagnostic technologies.

Obvious Combinations & Variations

Source Patent Element

MOF encapsulation method using zeolitic imidazolate framework (ZIF) for biological sample preservation

PTD Variation

Integration of smart container with real-time biomarker stability monitoring

Obviousness Reasoning

Adding sensor technology to track sample integrity is a predictable design improvement using known monitoring techniques in diagnostic technologies

Source Patent Element

Substrate preparation using water-insoluble materials for sample preservation

PTD Variation

MOF-encapsulated paper substrate with integrated micro-sensor

Obviousness Reasoning

Extending substrate materials and incorporating sensing capabilities represents an obvious design choice for improving sample tracking and preservation

Source Patent Element

MOF preparation using 2-methylimidazole and zinc acetate precursors

PTD Variation

Cloud-based biospecimen management platform with predictive degradation algorithms

Obviousness Reasoning

Implementing data analytics and machine learning on existing preservation techniques is a standard technological progression for improving sample management

Source Patent Element

Method of contacting preserving agent with biological sample

PTD Variation

Portable biospecimen collection kit with vacuum-sealed container and drying apparatus

Obviousness Reasoning

Developing portable collection systems with enhanced preservation capabilities represents an obvious optimization for field-based sample collection

Source Patent Element

Metal-organic framework encapsulation for biological sample stability

PTD Variation

Point-of-care diagnostic device incorporating MOF preservation module with microfluidic processing

Obviousness Reasoning

Integrating preservation technologies with diagnostic platforms is a predictable technological convergence in biomedical engineering

35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11856945, a person having ordinary skill in the art would find the variations disclosed in this publication to be obvious extensions of the prior art, rendering potential patent claims covering similar technological implementations obvious and thus unpatentable under 35 U.S.C. Section 103.

Original Patent Information

Patent Number	US 11,856,945
Title	Methods and systems for preparing and preserving a biological sample
Assignee(s)	Washington University