Published Technical Disclosure Archive

Advanced MOF Biospecimen Preservation Technology

Publication ID: 24-11856945_0006_PTD
Published: October 26, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Advanced MOF Biospecimen Preservation Technology,” Published Technical Disclosure No. 24-11856945_0006_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856945_0006_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,945.

Background and Problem Solved

The original patent disclosed methods and systems for preparing and preserving biological samples using metal-organic framework (MOF) encapsulants. However, these approaches have inherent limitations, such as temperature sensitivity, cumbersome sample collection, and environmental concerns. The new invention addresses these limitations by introducing direct improvements and enhancements to the original patent, providing more efficient, safer, and environmentally-friendly solutions for biological sample preservation.

Novelty and Inventive Step

The new claims introduce significant improvements over the original patent, including enhanced thermal stability, facile sample collection, and environmentally-friendly preservation kits. These innovations provide a non-obvious solution to the limitations of the original patent, offering a substantial advantage in biological sample preservation.

Alternative Embodiments and Variations

Alternative embodiments of the invention may include the use of different metal-organic framework materials, substrates, or sample collection methods. Variations of the preservation kits may be designed for specific applications, such as protein therapeutics or biospecimen collection in resource-limited settings.

Potential Commercial Applications and Market

The enhanced biological sample preservation methods and systems have significant commercial potential in the biotechnology, pharmaceutical, and biomedical research industries. The invention's environmentally-friendly and energy-efficient approach can also appeal to organizations seeking to reduce their carbon footprint. The market for biological sample preservation is substantial, with growing demand for high-quality biospecimens in research and clinical diagnosis.

CPC Classifications

SectionClassGroup
A A01 A01N1/0231
G G01 G01N1/4044

Field of Art

Biological sample preservation technologies, focusing on metal-organic framework (MOF) encapsulation techniques for protein biomarker stabilization, with expertise in materials science, biochemistry, and sample handling methodologies

Person of Ordinary Skill (PHOSITA) Profile

A researcher or technician with advanced degrees in chemistry or biochemistry, familiar with protein preservation techniques, metal-organic framework synthesis, and sample collection strategies, possessing knowledge of thermal stability challenges in biological sample storage

Obviousness Rationale

A person of ordinary skill would recognize that the PTD's variations represent predictable extensions of the source patent's core MOF encapsulation technology. The disclosed improvements in thermal stability, sample collection methods, and preservation kit designs are logical adaptations of the fundamental MOF preservation approach. These variations demonstrate incremental innovations that would be apparent to a skilled practitioner seeking to address known limitations in biological sample preservation.

Obvious Combinations & Variations

Source Patent Element
Metal-organic framework (MOF) encapsulation method for biological samples
PTD Variation
Enhanced thermal stability MOF encapsulant specifically targeting protein biomarker preservation
Obviousness Reasoning
A PHOSITA would recognize that improving thermal stability is a predictable solution to known protein degradation challenges, using the established MOF encapsulation technique as a base technology
Source Patent Element
Zeolitic imidazolate framework (ZIF) type MOF preservation method
PTD Variation
Dry spot sample collection method using nanoporous MOF materials in resource-limited settings
Obviousness Reasoning
Adapting the MOF technology to alternative sample collection strategies represents a routine design optimization that would be obvious to a skilled practitioner seeking to expand the technology's applicability
Source Patent Element
Biological sample preservation using metal-organic framework encapsulants
PTD Variation
Preservation kit designed for protein therapeutics with specific handling instructions
Obviousness Reasoning
Creating specialized preservation kits for specific biological materials is a predictable variation that addresses known technical challenges in sample storage and transportation
Source Patent Element
MOF encapsulation with 2-methylimidazole and zinc acetate precursors
PTD Variation
Energy-efficient preservation method reducing cold chain dependency
Obviousness Reasoning
Developing alternative preservation methods that minimize temperature-controlled storage is a logical extension of the original MOF preservation technology, addressing known logistical challenges
Source Patent Element
Water insoluble substrate for MOF encapsulation
PTD Variation
Environmentally-friendly preservation approach with modified substrate materials
Obviousness Reasoning
Exploring alternative substrate materials and preservation approaches represents a routine materials science optimization that would be obvious to a skilled researcher
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11856945 and the disclosed variations, a person of ordinary skill in the art would find the claimed innovations obvious and anticipated, as the PTD demonstrates predictable extensions of the fundamental MOF encapsulation technology through routine optimization and design modifications that would be apparent to a skilled practitioner in biological sample preservation technologies.

Original Patent Information

Patent NumberUS 11,856,945
TitleMethods and systems for preparing and preserving a biological sample
Assignee(s)Washington University