Advanced MOF Biospecimen Preservation Technology

Publication ID: 24-11856945_0006_PTD
Published: October 26, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Advanced MOF Biospecimen Preservation Technology,” Published Technical Disclosure No. 24-11856945_0006_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856945_0006_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,945.

Background and Problem Solved

The original patent disclosed methods and systems for preparing and preserving biological samples using metal-organic framework (MOF) encapsulants. However, these approaches have inherent limitations, such as temperature sensitivity, cumbersome sample collection, and environmental concerns. The new invention addresses these limitations by introducing direct improvements and enhancements to the original patent, providing more efficient, safer, and environmentally-friendly solutions for biological sample preservation.

Novelty and Inventive Step

The new claims introduce significant improvements over the original patent, including enhanced thermal stability, facile sample collection, and environmentally-friendly preservation kits. These innovations provide a non-obvious solution to the limitations of the original patent, offering a substantial advantage in biological sample preservation.

Alternative Embodiments and Variations

Alternative embodiments of the invention may include the use of different metal-organic framework materials, substrates, or sample collection methods. Variations of the preservation kits may be designed for specific applications, such as protein therapeutics or biospecimen collection in resource-limited settings.

Potential Commercial Applications and Market

The enhanced biological sample preservation methods and systems have significant commercial potential in the biotechnology, pharmaceutical, and biomedical research industries. The invention's environmentally-friendly and energy-efficient approach can also appeal to organizations seeking to reduce their carbon footprint. The market for biological sample preservation is substantial, with growing demand for high-quality biospecimens in research and clinical diagnosis.

CPC Classifications

SectionClassGroup
A A01 A01N1/0231
G G01 G01N1/4044

Original Patent Information

Patent NumberUS 11,856,945
TitleMethods and systems for preparing and preserving a biological sample
Assignee(s)Washington University