Published Technical Disclosure Archive

Advanced MOF Biospecimen Preservation Technology

Publication ID: 24-11856945_0009_PTD
Published: October 26, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Advanced MOF Biospecimen Preservation Technology,” Published Technical Disclosure No. 24-11856945_0009_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856945_0009_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,945.

Background and Problem Solved

The original patent disclosed methods and systems for preparing and preserving biological samples using metal-organic frameworks (MOFs) encapsulants. However, these methods may not be suitable for specific, narrow market or unique operational environments. This invention addresses the limitations of the original patent by providing tailored solutions for these specialized contexts.

Novelty and Inventive Step

The new claims introduce novel combinations of MOF encapsulant technology with specialized components and operational parameters tailored to specific environments. These adaptations provide a non-obvious improvement over the original patent, enabling the preservation of biological samples in unique contexts.

Alternative Embodiments and Variations

Alternative embodiments of the invention could include using different types of MOFs, varying the molar ratio of precursors, or incorporating additional components to enhance stability or security. Other variations could include adapting the invention for use with different types of biological samples or integrating the technology with existing laboratory equipment.

Potential Commercial Applications and Market

This invention has significant commercial potential in industries such as biomedical research, clinical diagnosis, and biotechnology, particularly in areas requiring specialized sample preservation solutions. Target markets may include government agencies, research institutions, and private companies operating in high-security, extreme weather, disaster relief, high-altitude, or high-radiation environments.

CPC Classifications

SectionClassGroup
A A01 A01N1/0231
G G01 G01N1/4044

Field of Art

Biological sample preservation techniques, focusing on molecular stabilization and encapsulation technologies, with expertise in materials science, biochemistry, and sample handling protocols

Person of Ordinary Skill (PHOSITA) Profile

A researcher or laboratory professional with advanced degrees in chemistry or biochemistry, familiar with metal-organic framework (MOF) technologies, sample preservation methods, and environmental adaptation strategies for biological specimens

Obviousness Rationale

A PHOSITA would recognize that the PTD's variations represent predictable extensions of the source patent's core MOF encapsulation technology by applying known preservation techniques to specific environmental contexts. The fundamental MOF encapsulation mechanism remains consistent, with modifications representing routine engineering adaptations to address specialized preservation challenges. These variations demonstrate standard problem-solving approaches within the biological sample preservation domain.

Obvious Combinations & Variations

Source Patent Element
MOF encapsulant using 2-methylimidazole and zinc acetate for biological sample preservation
PTD Variation
Adapting MOF encapsulant for high-radiation environments with radiation-resistant modifications
Obviousness Reasoning
A PHOSITA would recognize that modifying MOF chemical composition to enhance radiation resistance represents a predictable materials engineering solution using known techniques of molecular design
Source Patent Element
Water insoluble substrate for sample storage
PTD Variation
Water-resistant substrate for preserving samples in extreme weather conditions
Obviousness Reasoning
Selecting materials with enhanced environmental resistance is a standard design choice for a PHOSITA addressing sample preservation challenges
Source Patent Element
MOF encapsulation method for protein biomarker stabilization
PTD Variation
Integrating tamper-evident containers and communication technologies for secure sample management
Obviousness Reasoning
Combining established preservation techniques with additional security and tracking mechanisms represents an obvious technological enhancement using known laboratory protocols
Source Patent Element
Zeolitic imidazolate framework (ZIF) type MOF for sample preservation
PTD Variation
MOF encapsulant with enhanced oxygen barrier properties for high-altitude environments
Obviousness Reasoning
Modifying MOF characteristics to address specific environmental challenges is a routine materials science approach with predictable problem-solving strategies
Source Patent Element
Metal-organic framework encapsulation technique
PTD Variation
Portable MOF encapsulation kit for disaster relief scenarios
Obviousness Reasoning
Developing field-deployable versions of laboratory techniques represents an obvious technological adaptation for practical application in emergency contexts
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11856945, a person having ordinary skill in the art would find the variations disclosed in this publication to represent obvious extensions of existing MOF encapsulation technologies. The claimed innovations constitute predictable combinations of known preservation techniques with specific environmental adaptations, thereby rendering potential patent claims in this domain obvious and unpatentable under 35 U.S.C. Section 103.

Original Patent Information

Patent NumberUS 11,856,945
TitleMethods and systems for preparing and preserving a biological sample
Assignee(s)Washington University