Published Technical Disclosure Archive

Next-Gen MOF Biopreservation: Decentralized Sample Tech

Publication ID: 24-11856945_0010_PTD
Published: October 26, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Next-Gen MOF Biopreservation: Decentralized Sample Tech,” Published Technical Disclosure No. 24-11856945_0010_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856945_0010_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,945.

Background and Problem Solved

The original patent disclosed methods and systems for preparing and preserving biological samples using metal-organic framework (MOF) encapsulants. However, these methods have limitations in terms of scalability, portability, and adaptability to diverse sample types and collection settings. The new invention addresses these limitations by envisioning next-generation systems that can preserve biological samples in resource-limited settings, decentralized point-of-care settings, and even on the human body.

Novelty and Inventive Step

The new claims introduce several novel and non-obvious features, including the use of wearable, flexible substrates; autonomous, robotic devices; and custom-designed, adaptive MOF materials. These features enable the preservation of biological samples in unprecedented ways, such as on the human body or in decentralized settings.

Alternative Embodiments and Variations

Alternative embodiments may include the use of different types of MOF materials, substrates, or microfluidic devices. Variations may include integrating the systems with artificial intelligence, blockchain technology, or other data management platforms to enhance their functionality and security.

Potential Commercial Applications and Market

The next-generation biological sample preservation systems have vast commercial potential in industries such as healthcare, biotechnology, and pharmaceuticals. They can enable decentralized, point-of-care diagnostics, remote patient monitoring, and personalized medicine, among other applications.

CPC Classifications

SectionClassGroup
A A01 A01N1/0231
G G01 G01N1/4044

Field of Art

Biospecimen preservation technologies, focusing on molecular stabilization techniques using metal-organic frameworks (MOFs) for biological sample storage and analysis

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or materials scientist with expertise in molecular encapsulation, microfluidics, and sample preservation techniques, holding advanced degrees and familiar with emerging preservation technologies

Obviousness Rationale

A PHOSITA would recognize that the PTD's variations represent predictable extensions of the source patent's core MOF encapsulation technology, applying known design principles to enhance sample preservation in novel contexts such as wearable devices and decentralized collection systems. The fundamental molecular stabilization mechanism remains consistent, with the PTD merely introducing contextual and implementation variations that would be obvious to a skilled practitioner seeking to expand the utility of MOF-based preservation techniques.

Obvious Combinations & Variations

Source Patent Element
Metal-organic framework encapsulation for biological sample preservation
PTD Variation
Incorporating MOF encapsulation into wearable, flexible substrates and portable devices
Obviousness Reasoning
A PHOSITA would recognize that adapting MOF technologies to wearable formats represents a predictable design evolution driven by the desire for more convenient and continuous sample preservation
Source Patent Element
Zeolitic imidazolate framework (ZIF) type MOF materials
PTD Variation
Custom-designed adaptive MOF materials using machine learning algorithms
Obviousness Reasoning
Material optimization through computational techniques is a standard approach in materials science, representing an obvious extension of existing MOF development methodologies
Source Patent Element
Biological sample preservation using metal-organic framework encapsulants
PTD Variation
Integrating microfluidic systems and cloud-based data storage for decentralized sample collection
Obviousness Reasoning
Combining preservation technologies with digital monitoring systems is a predictable technological convergence that would be obvious to a PHOSITA seeking to enhance sample tracking and analysis capabilities
Source Patent Element
Protein biomarker stabilization using MOF encapsulation
PTD Variation
Point-of-care preservation systems using autonomous robotic devices
Obviousness Reasoning
Developing automated sample collection and preservation systems represents a logical technological progression in biospecimen management, utilizing known robotics and MOF encapsulation principles
35 U.S.C. § 103 Summary: Based on US Patent 11856945's teachings of metal-organic framework encapsulation for biological sample preservation, the present publication demonstrates that the claimed variations represent obvious extensions of prior art through predictable combinations of known techniques, thereby rendering subsequent claims of novelty invalid under standard obviousness analysis.

Original Patent Information

Patent NumberUS 11,856,945
TitleMethods and systems for preparing and preserving a biological sample
Assignee(s)Washington University