Advanced Cryopreservation System for Biological Materials

Publication ID: 24-11856947_0001_PTD
Published: October 26, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Advanced Cryopreservation System for Biological Materials,” Published Technical Disclosure No. 24-11856947_0001_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856947_0001_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,947.

Background and Problem Solved

The original patent disclosed a system for automated permeation of biological materials, but it lacked critical features to ensure optimal cryopreservation. The manual procedure of permeating cells into vitrification solutions is time-consuming, labor-intensive, and prone to human error. The new invention addresses these limitations by introducing a temperature control module, real-time monitoring of cryoprotectant agent concentrations, and adaptive flow rate adjustment to minimize exposure time and oxidative stress.

Novelty and Inventive Step

The new claims introduce novel features that significantly improve the original patent's functionality. The temperature control module, real-time monitoring, and adaptive flow rate adjustment are non-obvious enhancements that address the inherent limitations of the original invention. These features provide a more efficient, safe, and reliable cryopreservation process.

Alternative Embodiments and Variations

Alternative embodiments of the invention could include the use of different temperature control methods, such as thermoelectric cooling or heating, or the integration of additional sensors to monitor other parameters, such as pH or oxygen levels. The system could also be adapted for use with different types of biological materials or vitrification solutions.

Potential Commercial Applications and Market

The enhanced system has significant commercial potential in the fields of regenerative medicine, biotechnology, and pharmaceuticals, where cryopreservation of cells and biological materials is a critical step in the development of new therapies and treatments. The market for cryopreservation solutions is growing rapidly, and this invention is well-positioned to capitalize on this trend.

CPC Classifications

SectionClassGroup
A A01 A01N1/0268
A A01 A01N1/0221
A A01 A01N1/0242
B B01 B01L3/502

Original Patent Information

Patent NumberUS 11,856,947
TitleSystem for automated permeation of a biological material and method of using same
Assignee(s)Cook Medical Technologies LLC