Advanced Cryopreservation System for Biological Materials
Legal Citation
Background and Problem Solved
The original patent disclosed a system for automated permeation of biological materials, but it lacked critical features to ensure optimal cryopreservation. The manual procedure of permeating cells into vitrification solutions is time-consuming, labor-intensive, and prone to human error. The new invention addresses these limitations by introducing a temperature control module, real-time monitoring of cryoprotectant agent concentrations, and adaptive flow rate adjustment to minimize exposure time and oxidative stress.
Novelty and Inventive Step
The new claims introduce novel features that significantly improve the original patent's functionality. The temperature control module, real-time monitoring, and adaptive flow rate adjustment are non-obvious enhancements that address the inherent limitations of the original invention. These features provide a more efficient, safe, and reliable cryopreservation process.
Alternative Embodiments and Variations
Alternative embodiments of the invention could include the use of different temperature control methods, such as thermoelectric cooling or heating, or the integration of additional sensors to monitor other parameters, such as pH or oxygen levels. The system could also be adapted for use with different types of biological materials or vitrification solutions.
Potential Commercial Applications and Market
The enhanced system has significant commercial potential in the fields of regenerative medicine, biotechnology, and pharmaceuticals, where cryopreservation of cells and biological materials is a critical step in the development of new therapies and treatments. The market for cryopreservation solutions is growing rapidly, and this invention is well-positioned to capitalize on this trend.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A01 | A01N1/0268 |
| A | A01 | A01N1/0221 |
| A | A01 | A01N1/0242 |
| B | B01 | B01L3/502 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Biological material preservation, specifically cell cryopreservation techniques involving vitrification and specialized laboratory devices for cell handling and temperature-controlled processing
Person of Ordinary Skill (PHOSITA) Profile
A biomedical engineer or laboratory technician with expertise in cell biology, cryogenic preservation techniques, microfluidic device design, and experience with advanced cell handling protocols
Obviousness Rationale
A person skilled in the art would recognize that the proposed variations represent predictable engineering improvements to the existing automated permeation system, utilizing known techniques in temperature control, sensor integration, and adaptive flow management that are standard design considerations in biological preservation technologies.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,856,947 |
|---|---|
| Title | System for automated permeation of a biological material and method of using same |
| Assignee(s) | Cook Medical Technologies LLC |