Published Technical Disclosure Archive

Advanced Cryopreservation System for Specialized Environments

Publication ID: 24-11856947_0004_PTD
Published: October 26, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Advanced Cryopreservation System for Specialized Environments,” Published Technical Disclosure No. 24-11856947_0004_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856947_0004_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,947.

Background and Problem Solved

The original patent (System for automated permeation of a biological material and method of using same) provides a solution for cryopreserving cells through vitrification. However, it does not address the unique challenges and requirements of specialized environments. The current invention addresses these limitations by adapting the permeation system to specific niches, ensuring the safe and efficient cryopreservation of biological materials in diverse settings.

Novelty and Inventive Step

The new claims introduce novel features and combinations of features that are not obvious from the original patent. The inventive step lies in the adaptation of the permeation system to specific niches, which requires a deep understanding of the unique challenges and requirements of each environment.

Alternative Embodiments and Variations

Alternative embodiments may include the use of different materials, such as biocompatible metals or ceramics, for the device's construction. Variations may also include the integration of sensors and monitoring systems to ensure the quality and safety of the biological materials during permeation.

Potential Commercial Applications and Market

The invention has significant commercial potential in various industries, including biotechnology, pharmaceuticals, and medical research. The specialized systems can be marketed to laboratories, research institutions, and organizations operating in extreme or specialized environments, providing a unique solution for their specific needs.

CPC Classifications

SectionClassGroup
A A01 A01N1/0268
A A01 A01N1/0221
A A01 A01N1/0242
B B01 B01L3/502

Field of Art

Biological material preservation and handling technologies, specifically cell vitrification and cryopreservation systems, involving microfluidic device design and biological sample processing

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or laboratory technician with expertise in cell preservation techniques, microfluidic device design, and experience with cryoprotectant agent handling, possessing knowledge of materials science, fluid dynamics, and biological sample manipulation

Obviousness Rationale

A PHOSITA would recognize that the source patent's fundamental permeation device design provides a flexible platform that can be readily adapted to specialized environmental conditions by applying standard engineering modifications. The core structural elements of the original device remain consistent across the PTD variations, with predictable adaptations to address specific operational contexts. These modifications represent routine design optimization that would be apparent to a skilled practitioner familiar with biological sample handling technologies.

Obvious Combinations & Variations

Source Patent Element
Device with lower and upper portions connected via hinge or mechanical clip
PTD Variation
Adding secure locking mechanism for high-security laboratory environments
Obviousness Reasoning
Implementing additional security features represents a predictable design variation for sensitive biological materials, using known mechanical locking techniques familiar to laboratory equipment designers
Source Patent Element
Clear plastic or translucent device construction
PTD Variation
Ruggedized exterior for disaster relief situations with battery-powered operation
Obviousness Reasoning
Modifying material properties and power systems represents standard engineering adaptation for extreme use cases, utilizing known materials and power technologies
Source Patent Element
Device configured with reservoirs for fluid transfer
PTD Variation
Low-power consumption mode for remote or resource-limited areas
Obviousness Reasoning
Implementing power management strategies is a routine optimization for portable scientific equipment, involving well-understood electrical engineering principles
Source Patent Element
Suction and positive pressure device coupling
PTD Variation
Temperature-resistant design for extreme environmental conditions
Obviousness Reasoning
Extending operational temperature range represents a standard materials science approach, involving selection of appropriate polymers or composite materials with known thermal properties
Source Patent Element
Biological material groove and reservoir system
PTD Variation
High-altitude operational configuration
Obviousness Reasoning
Adapting fluid handling systems for pressure differentials is a predictable engineering solution using known fluid dynamics principles
35 U.S.C. § 103 Summary: Based on US Patent 11856947, the present disclosure demonstrates that the claimed variations in biological material permeation devices would have been obvious to a person having ordinary skill in the art at the time of invention. The disclosed modifications represent routine engineering adaptations that would be apparent to a skilled practitioner, utilizing standard design techniques to extend the fundamental device concept into specialized operational contexts.

Original Patent Information

Patent NumberUS 11,856,947
TitleSystem for automated permeation of a biological material and method of using same
Assignee(s)Cook Medical Technologies LLC