Published Technical Disclosure Archive

AI-Enhanced Cryopreservation: Automated Biotech Solution

Publication ID: 24-11856947_0008_PTD
Published: October 26, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “AI-Enhanced Cryopreservation: Automated Biotech Solution,” Published Technical Disclosure No. 24-11856947_0008_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856947_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,947.

Background and Problem Solved

Current cryopreservation methods rely on manual permeation of biological materials, resulting in variability, low efficiency, and high risk of contamination. The original patent addressed this issue with a device for automated permeation, but lacked integration with advanced technologies. The present invention overcomes these limitations by combining the patented device with AI, IoT, blockchain, and novel materials to create a more powerful, efficient, and secure system.

Novelty and Inventive Step

The integration of AI, IoT, blockchain, and novel materials with the patented device for automated permeation of biological materials constitutes a novel and non-obvious combination that revolutionizes the cryopreservation process. The inventive step lies in the synergistic combination of these distinct technologies, resulting in a more efficient, secure, and accurate system.

Alternative Embodiments and Variations

Alternative embodiments may include integrating the device with other advanced technologies, such as computer vision or robotics, to further enhance the permeation process. Variations may include adapting the system for use in different industries, such as pharmaceuticals or biotechnology, or developing miniaturized versions for point-of-care applications.

Potential Commercial Applications and Market

The invention has significant commercial potential in the cryopreservation industry, with applications in cell therapy, regenerative medicine, and biobanking. The market for cryopreservation solutions is expected to grow significantly, driven by increasing demand for efficient and secure methods for preserving biological materials.

CPC Classifications

SectionClassGroup
A A01 A01N1/0268
A A01 A01N1/0221
A A01 A01N1/0242
B B01 B01L3/502

Field of Art

Biological material preservation and cryogenic processing, specifically involving cell permeation techniques, with expertise in microfluidic device design, biotechnology laboratory procedures, and advanced material science

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced degree in bioengineering or biotechnology, familiar with cryopreservation techniques, microfluidic device design, and emerging technologies in biological sample processing, with working knowledge of AI, IoT, and data management systems

Obviousness Rationale

A PHOSITA would recognize that integrating digital technologies and advanced materials into the existing biological permeation device represents a predictable extension of the source patent's core technological framework. The fundamental permeation mechanism remains consistent, with technological enhancements providing incremental improvements in monitoring, control, and process optimization. These variations represent standard engineering approaches to modernizing existing biotechnological instrumentation through known technological integration strategies.

Obvious Combinations & Variations

Source Patent Element
Device for biological material permeation with reservoirs and precise spatial configuration
PTD Variation
Integration of AI module to monitor and control permeation process parameters
Obviousness Reasoning
Automated process control is a known technique in biotechnology, with predictable results of improved precision and reduced human error
Source Patent Element
Plastic device designed for biological material handling
PTD Variation
Novel biocompatible material with enhanced thermal conductivity
Obviousness Reasoning
Material science optimization is a standard design approach, with finite identifiable material improvements that a PHOSITA would consider routine engineering
Source Patent Element
Device configured for suction and positive pressure interactions
PTD Variation
IoT network connectivity for remote monitoring and cloud-based interface control
Obviousness Reasoning
Remote instrumentation and network integration are well-established techniques in laboratory equipment design, representing a predictable technological progression
Source Patent Element
Biological material permeation device with precise spatial reservoirs
PTD Variation
Blockchain-based data management system for secure process tracking
Obviousness Reasoning
Data security and traceability are standard considerations in scientific instrumentation, with blockchain representing an obvious technological solution for process documentation
Source Patent Element
Manual and automated permeation techniques for biological materials
PTD Variation
Machine learning algorithm for predicting and dynamically adjusting permeation parameters
Obviousness Reasoning
Adaptive process optimization through machine learning is a known technique in biotechnological systems, representing a predictable application of computational intelligence
35 U.S.C. § 103 Summary: Based on US Patent 11856947's disclosure of a biological material permeation device, the present publication demonstrates that integrating contemporary digital technologies and advanced materials represents an obvious technological progression that would be readily conceived by a Person Having Ordinary Skill In The Art, thereby establishing prior art that anticipates and renders obvious potential patent claims involving similar technological combinations in biological sample processing instrumentation.

Original Patent Information

Patent NumberUS 11,856,947
TitleSystem for automated permeation of a biological material and method of using same
Assignee(s)Cook Medical Technologies LLC