Advanced Cryopreservation System for Extreme Environments

Publication ID: 24-11856947_0009_PTD
Published: October 26, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Advanced Cryopreservation System for Extreme Environments,” Published Technical Disclosure No. 24-11856947_0009_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856947_0009_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,947.

Background and Problem Solved

The original patent, titled 'System for automated permeation of a biological material and method of using same', addresses the need for efficient and reliable cryopreservation of cells through vitrification. However, the original invention does not account for the specific challenges and requirements of niche environments, such as high-security biorepositories, extreme weather conditions, disaster relief scenarios, high-altitude or high-temperature environments, and sterile, isolated environments. The present invention addresses these limitations by providing specialized systems and methods tailored to these unique operational environments.

Novelty and Inventive Step

The present invention's novelty and inventive step reside in its provision of specialized systems and methods that adapt the original invention to specific, narrow markets or unique operational environments. The new claims introduce unique features, such as tamper-evident enclosures, secure authentication mechanisms, portable battery-powered devices, compact lightweight designs, pressure-resistant enclosures, and hermetically sealed devices, which are not present in the original patent and provide a non-obvious solution to the challenges of niche environments.

Alternative Embodiments and Variations

Alternative embodiments of the invention may include modifications to the device design, materials, and operational parameters to further adapt to specific niche environments. For example, the device could be designed with additional safety features for use in high-risk environments or with enhanced portability for use in remote areas. Variations of the method could include alternative cryopreservation protocols or specialized training programs for users operating in unique environments.

Potential Commercial Applications and Market

The present invention has significant commercial potential in various industries, including biotechnology, pharmaceuticals, and healthcare, particularly in areas where specialized cryopreservation solutions are required. The invention's adaptability to niche environments enables it to address specific market needs, such as high-security biorepositories, disaster relief, and extreme weather conditions, providing a competitive advantage in these markets.

CPC Classifications

SectionClassGroup
A A01 A01N1/0268
A A01 A01N1/0221
A A01 A01N1/0242
B B01 B01L3/502

Field of Art

Biological material preservation, specifically cell cryopreservation techniques, involving biotechnology, laboratory equipment design, and sample handling protocols

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or laboratory technician with expertise in cell biology, cryogenic preservation methods, and specialized laboratory device design, holding at least a master's degree with practical experience in cell handling and preservation techniques

Obviousness Rationale

A person having ordinary skill would recognize that the PTD's variations represent predictable adaptations of the source patent's core technology, applying standard engineering design principles to extend the device's utility across different operational contexts. The fundamental mechanism of biological material permeation remains consistent, with modifications representing routine engineering adaptations to specific environmental constraints. These variations demonstrate standard problem-solving approaches typical in biomedical device design.

Obvious Combinations & Variations

Source Patent Element
Device with upper and lower portions for supporting biological material during permeation process
PTD Variation
Adding tamper-evident enclosure and secure authentication mechanism for high-security biorepositories
Obviousness Reasoning
Implementing security features is a predictable design modification for sensitive biological materials, representing a known technique in laboratory equipment design to control access and maintain sample integrity
Source Patent Element
Plastic device with reservoirs for cryopreservation solutions
PTD Variation
Developing portable, battery-powered version for use in remote or disaster relief scenarios
Obviousness Reasoning
Adapting laboratory equipment for field use is a standard engineering approach, involving known techniques of miniaturization and power source integration
Source Patent Element
Device configured for coupling with suction or positive pressure devices
PTD Variation
Creating pressure-resistant enclosure for high-altitude or extreme temperature environments
Obviousness Reasoning
Modifying device structural characteristics to withstand environmental variations represents a predictable solution using known materials engineering principles
Source Patent Element
Clear or translucent device with visualization capabilities
PTD Variation
Implementing hermetic sealing and sterilization protocols for isolated environments
Obviousness Reasoning
Enhancing sample containment and sterility represents a logical extension of existing device design principles, addressing known challenges in biological material preservation
Source Patent Element
Modular device design with connectable upper and lower portions
PTD Variation
Developing compact, lightweight design with manual operation mode for areas with limited infrastructure
Obviousness Reasoning
Simplifying device functionality for alternative use contexts represents a standard engineering approach to expanding technological applicability
35 U.S.C. § 103 Summary: Based on US Patent 11856947's fundamental teachings, the present publication demonstrates that the claimed variations represent obvious extensions of existing cryopreservation technology, employing standard engineering modifications that would be readily conceived by a person having ordinary skill in biological material preservation techniques. The disclosed adaptations constitute prima facie obviousness by applying predictable design variations to a known technological framework.

Original Patent Information

Patent NumberUS 11,856,947
TitleSystem for automated permeation of a biological material and method of using same
Assignee(s)Cook Medical Technologies LLC