Advanced Automated Cell Cryopreservation Technology
Legal Citation
Background and Problem Solved
Current methods for cryopreserving cells through vitrification rely on manual procedures, which are time-consuming, labor-intensive, and prone to human error. The original patent addressed this issue with a device for automated permeation, but its limitations in terms of precision, efficiency, and adaptability to different cell types and cryoprotectant concentrations remain. This new invention overcomes these limitations by integrating advanced technologies to create a more efficient, accurate, and customizable permeation process.
Novelty and Inventive Step
The new claims introduce a paradigm shift in cryopreservation technology by integrating robotics, artificial intelligence, and microfluidics to create a highly efficient, adaptable, and precise permeation process. The use of machine learning algorithms to optimize permeation protocols, electroporation to enhance cryoprotectant uptake, and interchangeable cartridges for customized protocols are all novel and non-obvious advancements over the original patent.
Alternative Embodiments and Variations
Alternative embodiments of the invention could include the use of other types of automation, such as pneumatic or hydraulic systems, or the integration of additional sensors and monitoring systems to further optimize the permeation process. Variations of the invention could also include the use of different types of cryoprotectant agents, or the application of the technology to other types of biological materials.
Potential Commercial Applications and Market
The advanced system for automated permeation of biological materials has significant commercial potential in the fields of regenerative medicine, biobanking, and cryopreservation. The technology could be used to improve the efficiency and accuracy of cryopreservation processes, leading to increased adoption and market growth. Potential target industries include pharmaceutical companies, research institutions, and biotechnology companies.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A01 | A01N1/0268 |
| A | A01 | A01N1/0221 |
| A | A01 | A01N1/0242 |
| B | B01 | B01L3/502 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Biological material preservation and cryogenic processing, specifically cell vitrification techniques involving microfluidic systems, automation, and cryoprotectant permeation protocols
Person of Ordinary Skill (PHOSITA) Profile
A biomedical engineer or biotechnologist with expertise in cell preservation techniques, microfluidic device design, robotic automation, and machine learning applications in biological processing, holding advanced degrees in bioengineering or related fields
Obviousness Rationale
A PHOSITA would recognize that the disclosed variations represent predictable technological extensions of the source patent's core permeation system, utilizing standard engineering approaches like robotics, machine learning, and microfluidic optimization to address known limitations in manual cell preservation processes. The proposed modifications represent incremental improvements using well-established techniques in biotechnology and automation. The variations demonstrate systematic problem-solving approaches that would be obvious to a skilled practitioner seeking to enhance the efficiency and precision of cell vitrification methods.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,856,947 |
|---|---|
| Title | System for automated permeation of a biological material and method of using same |
| Assignee(s) | Cook Medical Technologies LLC |