Advanced Automated Cell Cryopreservation Technology

Publication ID: 24-11856947_0010_PTD
Published: October 26, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Advanced Automated Cell Cryopreservation Technology,” Published Technical Disclosure No. 24-11856947_0010_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856947_0010_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,947.

Background and Problem Solved

Current methods for cryopreserving cells through vitrification rely on manual procedures, which are time-consuming, labor-intensive, and prone to human error. The original patent addressed this issue with a device for automated permeation, but its limitations in terms of precision, efficiency, and adaptability to different cell types and cryoprotectant concentrations remain. This new invention overcomes these limitations by integrating advanced technologies to create a more efficient, accurate, and customizable permeation process.

Novelty and Inventive Step

The new claims introduce a paradigm shift in cryopreservation technology by integrating robotics, artificial intelligence, and microfluidics to create a highly efficient, adaptable, and precise permeation process. The use of machine learning algorithms to optimize permeation protocols, electroporation to enhance cryoprotectant uptake, and interchangeable cartridges for customized protocols are all novel and non-obvious advancements over the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the invention could include the use of other types of automation, such as pneumatic or hydraulic systems, or the integration of additional sensors and monitoring systems to further optimize the permeation process. Variations of the invention could also include the use of different types of cryoprotectant agents, or the application of the technology to other types of biological materials.

Potential Commercial Applications and Market

The advanced system for automated permeation of biological materials has significant commercial potential in the fields of regenerative medicine, biobanking, and cryopreservation. The technology could be used to improve the efficiency and accuracy of cryopreservation processes, leading to increased adoption and market growth. Potential target industries include pharmaceutical companies, research institutions, and biotechnology companies.

CPC Classifications

SectionClassGroup
A A01 A01N1/0268
A A01 A01N1/0221
A A01 A01N1/0242
B B01 B01L3/502

Original Patent Information

Patent NumberUS 11,856,947
TitleSystem for automated permeation of a biological material and method of using same
Assignee(s)Cook Medical Technologies LLC