Advanced Colloidal Particle Formulation Reactor Tech

Publication ID: 24-11856948_0001_PTD
Published: October 26, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Advanced Colloidal Particle Formulation Reactor Tech,” Published Technical Disclosure No. 24-11856948_0001_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856948_0001_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,948.

Background and Problem Solved

The original patent disclosed a composite colloidal particle formulation with advanced functionality, comprising an engineered biodegradable particle core dispersed in a bioadhesive polyelectrolyte solution. However, the original patent had limitations in terms of scalability, stability, and manufacturing cost. This new invention addresses these limitations by introducing a modular, continuous-flow reactor for efficient mixing, a downstream processing unit for concentrating the formulation, and other innovations that enhance the overall efficiency and effectiveness of the formulation.

Novelty and Inventive Step

The new claims introduce novel and non-obvious improvements to the original patent, including the use of a modular, continuous-flow reactor, the addition of a secondary polyelectrolyte solution, the use of a cross-linking agent, real-time monitoring of formulation production, and the substitution of a low-cost, biorenewable anti-solvent. These innovations provide significant enhancements to the scalability, stability, and cost-effectiveness of the colloidal particle formulations.

Alternative Embodiments and Variations

Alternative embodiments of the invention could include the use of different reactor designs, varying the composition of the polyelectrolyte solution, or incorporating additional functional agents to enhance the formulation's properties. Variations of the invention could also include adapting the system for real-time monitoring to different types of particle formulations or integrating the system with existing manufacturing infrastructure.

Potential Commercial Applications and Market

The invention has significant commercial potential in various industries, including pharmaceuticals, biotechnology, cosmetics, and food processing, where scalable, efficient, and cost-effective production of advanced colloidal particle formulations is crucial. The invention's ability to enhance the stability, bioadhesive properties, and manufacturing efficiency of these formulations could lead to widespread adoption and significant market impact.

CPC Classifications

SectionClassGroup
A A01 A01N25/22
A A01 A01N25/04
A A01 A01N25/10
A A01 A01N59/20

Field of Art

Colloidal particle formulation technologies, specifically biodegradable particle engineering and polyelectrolyte processing, with expertise in chemical engineering, materials science, and pharmaceutical formulation techniques

Person of Ordinary Skill (PHOSITA) Profile

A chemical engineer or materials scientist with advanced degree, experienced in particle engineering, familiar with solvent-antisolvent precipitation techniques, polyelectrolyte interactions, and scalable manufacturing processes

Obviousness Rationale

A PHOSITA would recognize that the PTD's variations represent predictable engineering improvements to the source patent's core colloidal particle formulation methodology. The disclosed modifications leverage standard techniques in particle engineering and manufacturing optimization that would be readily apparent to someone skilled in the art. The variations represent incremental enhancements that apply known strategies for improving particle production, stability, and cost-effectiveness.

Obvious Combinations & Variations

Source Patent Element
Ethanol-based solvent and anti-solvent mixing in T-piece system for particle formation
PTD Variation
Modular continuous-flow reactor with downstream processing unit
Obviousness Reasoning
Scaling and modularizing particle production systems is a standard engineering design choice with predictable optimization outcomes
Source Patent Element
Bioadhesive polyelectrolyte solution containing biodegradable particle core
PTD Variation
Adding secondary polyelectrolyte solution and cross-linking agent to enhance particle interactions
Obviousness Reasoning
Modifying polyelectrolyte composition to improve particle stability is a known technique in colloidal engineering with finite, predictable approaches
Source Patent Element
Basic particle formation method using solvent-antisolvent precipitation
PTD Variation
Real-time monitoring system with in-line sensors for particle size and concentration control
Obviousness Reasoning
Process monitoring and parameter optimization are standard quality control techniques in advanced manufacturing processes
Source Patent Element
Water-based anti-solvent system for particle precipitation
PTD Variation
Low-cost, biorenewable alternative anti-solvent to reduce manufacturing expenses
Obviousness Reasoning
Substituting solvents with equivalent functional properties is a routine engineering optimization strategy
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11856948, a Person Having Ordinary Skill In The Art would find the variations disclosed in this Published Technical Disclosure to represent obvious extensions of the prior art, employing standard engineering techniques to incrementally improve colloidal particle formulation processes through predictable modifications in reactor design, polyelectrolyte composition, monitoring strategies, and solvent selection.

Original Patent Information

Patent NumberUS 11,856,948
TitleColloidal particle formulations with advanced functionality
Assignee(s)BENANOVA INC.