Advanced Biodegradable Colloidal Particle Formulation

Publication ID: 24-11856948_0006_PTD

Published: October 26, 2025

Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Advanced Biodegradable Colloidal Particle Formulation,” Published Technical Disclosure No. 24-11856948_0006_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856948_0006_PTD

This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,948.

Background and Problem Solved

The original patent disclosed a composite colloidal particle formulation with advanced functionality, comprising an engineered biodegradable particle core dispersed in a bioadhesive polyelectrolyte solution. However, the original invention had limitations in terms of scalability, stability, and biocompatibility. The new invention addresses these limitations by introducing a scalable semi-continuous process, adding stabilizing agents, and surface-modifying the particle core for improved biocompatibility.

Novelty and Inventive Step

The new claims introduce a scalable semi-continuous process, real-time monitoring and control, and improved biocompatibility through surface modification and stabilizing agents, which are not disclosed in the original patent. The combination of these features provides a novel and non-obvious solution to the limitations of the original invention.

Alternative Embodiments and Variations

Alternative embodiments of the invention could include different types of stabilizing agents, surface modifications, and machine learning algorithms. Additionally, the system for large-scale production could be adapted for use with different types of colloidal particle formulations.

Potential Commercial Applications and Market

The invention has potential commercial applications in the pharmaceutical, cosmetic, and biomedical industries, where colloidal particle formulations with advanced functionality are in high demand. The scalable production system and improved biocompatibility features of the invention make it an attractive solution for companies looking to develop and commercialize novel colloidal particle formulations.

CPC Classifications

Section	Class	Group
A	A01	A01N25/22
A	A01	A01N25/04
A	A01	A01N25/10
A	A01	A01N59/20

Section 103 Obviousness Analysis (PHOSITA)

▼

Field of Art

Colloidal particle engineering, specifically biodegradable particle formulation and processing techniques in pharmaceutical and materials science, with expertise in polyelectrolyte solutions, particle synthesis, and advanced manufacturing processes

Person of Ordinary Skill (PHOSITA) Profile

A PhD or advanced engineering professional with expertise in chemical engineering, materials science, or pharmaceutical formulation, possessing knowledge of colloidal particle synthesis, surface modification techniques, and scalable manufacturing processes

Obviousness Rationale

A person having ordinary skill would recognize that the PTD's variations represent predictable extensions of the source patent's core technology, utilizing standard engineering techniques to enhance colloidal particle formulation processes. The disclosed improvements in scalability, monitoring, and surface modification represent incremental advancements that would be apparent to a skilled practitioner familiar with colloidal particle engineering. These variations demonstrate standard problem-solving approaches in the field of advanced particle formulation.

Obvious Combinations & Variations

Source Patent Element

Engineered biodegradable particle core dispersed in bioadhesive polyelectrolyte solution

PTD Variation

Surface modification of particle core with biocompatible coating to enhance stability and performance

Obviousness Reasoning

Surface modification of colloidal particles is a known technique for improving particle characteristics, representing a predictable design optimization that would be obvious to a skilled practitioner

Source Patent Element

Ethanol-based solvent and anti-solvent particle formation method

PTD Variation

Scalable semi-continuous process with real-time monitoring and control of particle size distribution

Obviousness Reasoning

Process scale-up and implementation of monitoring techniques are standard engineering practices for improving manufacturing efficiency and product consistency

Source Patent Element

Biopolymer-based colloidal particle formulation

PTD Variation

Integration of machine learning algorithms to predict and adjust formulation parameters

Obviousness Reasoning

Application of computational techniques to optimize manufacturing processes is a well-known approach in advanced materials engineering, representing an obvious technological progression

Source Patent Element

Colloidal particle formulation in polyelectrolyte solution

PTD Variation

Addition of stabilizing agents like surfactants, polymers, and nanoparticles

Obviousness Reasoning

Selection and incorporation of stabilizing agents is a routine optimization technique in colloidal particle engineering, representing a finite set of known approaches to enhance formulation stability

35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. § 103, the variations disclosed in this Published Technical Disclosure would have been obvious to a person having ordinary skill in the art at the time of invention, as they represent predictable extensions of the technological teachings in US Patent 11856948, utilizing standard engineering techniques to enhance colloidal particle formulation processes through incremental improvements in scalability, monitoring, and surface modification.

Original Patent Information

Patent Number	US 11,856,948
Title	Colloidal particle formulations with advanced functionality
Assignee(s)	BENANOVA INC.