Published Technical Disclosure Archive

Advanced Olfactory Sensing Tech: Disruptive Biomarker Detection

Publication ID: 24-11856955_0002_PTD
Published: October 26, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Advanced Olfactory Sensing Tech: Disruptive Biomarker Detection,” Published Technical Disclosure No. 24-11856955_0002_PTD, Published October 26, 2025, available at https://archive.pr1or.art/24-11856955_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,856,955.

Background and Problem Solved

The original patent disclosed binary compositions capable of disrupting Orco-mediated odorant sensing in insects. However, these compositions were limited to agricultural pest control and disease vector management. The current invention expands the scope of this technology to tackle pressing issues in diverse industries, where the detection of volatile organic compounds, cancer biomarkers, environmental pollutants, and disease biomarkers is crucial.

Novelty and Inventive Step

The new claims introduce a paradigm shift by applying the core technology to entirely new fields, demonstrating non-obviousness and inventiveness. The inventive step lies in recognizing the potential of Orco-mediated odorant sensing disruptors beyond insect behavior modification and exploiting their capabilities to address critical challenges in diverse industries.

Alternative Embodiments and Variations

Alternative embodiments may include variations in the composition's formulation, such as nanoparticles, liposomes, or microemulsions, to enhance their efficacy and versatility. Additionally, the invention could be adapted for use in wearable devices, IoT sensors, or lab-on-a-chip platforms to expand its reach and impact.

Potential Commercial Applications and Market

This invention has far-reaching commercial potential in industries such as environmental monitoring, healthcare, food safety, and livestock management. The market for air quality monitoring alone is projected to reach $6.5 billion by 2025, and the invention's ability to address this need, as well as others, positions it for significant market impact and revenue growth.

CPC Classifications

SectionClassGroup
A A01 A01N43/653
A A01 A01N33/06
A A01 A01N2300/00

Field of Art

Chemical sensing technologies, olfactory receptor disruption, and analytical detection systems with a focus on volatile organic compound (VOC) analysis across biological and environmental domains

Person of Ordinary Skill (PHOSITA) Profile

A skilled practitioner with expertise in chemical engineering, analytical chemistry, and biotechnology, possessing knowledge of receptor-based sensing mechanisms, molecular interaction principles, and interdisciplinary detection methodologies

Obviousness Rationale

A PHOSITA would recognize that the Orco-mediated odorant sensing disruption technology disclosed in the source patent represents a fundamental molecular mechanism with broad applicability beyond insect behavior. The PTD's variations demonstrate predictable extensions of this core technology by applying the binary composition approach to alternative detection and sensing contexts using well-established analytical principles.

Obvious Combinations & Variations

Source Patent Element
Binary composition for disrupting odorant sensing in insect systems
PTD Variation
Adapting the binary composition to detect volatile organic compounds in air quality monitoring systems
Obviousness Reasoning
A PHOSITA would find it obvious to repurpose the receptor disruption mechanism for environmental sensing, as molecular detection principles are transferable across different detection domains
Source Patent Element
Composition formulated to inhibit host-sensing in insects
PTD Variation
Utilizing the binary composition to detect cancer biomarkers through breath sample analysis
Obviousness Reasoning
The underlying molecular interaction principles are consistent, and breath-based biomarker detection is a known analytical technique that would benefit from enhanced receptor disruption technologies
Source Patent Element
Water-soluble and aerosol formulation methods for the binary composition
PTD Variation
Implementing nanoparticle and microemulsion delivery systems for enhanced sensing capabilities
Obviousness Reasoning
Formulation optimization is a predictable design choice for a PHOSITA seeking to improve detection sensitivity and versatility across different application contexts
Source Patent Element
Odorant sensing disruption mechanism targeting Orco receptors
PTD Variation
Applying the technology to detect environmental pollutants and toxic gases
Obviousness Reasoning
Extending the receptor disruption mechanism to different molecular detection scenarios represents a logical and foreseeable technical progression for a skilled practitioner
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11856955 and the disclosed variations, a person having ordinary skill in the art would find the proposed technical extensions obvious and predictable. The binary composition's fundamental mechanism of odorant sensing disruption demonstrates clear transferability across multiple detection domains, rendering subsequent variations a matter of routine engineering design without requiring inventive insight.

Original Patent Information

Patent NumberUS 11,856,955
TitleBinary compositions as disruptors of Orco-mediated odorant sensing
Assignee(s)VANDERBILT UNIVERSITY