Fluorescence-Based Imaging for Non-Medical Applications

Publication ID: 24-11857164_0002_PTD
Published: November 07, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Fluorescence-Based Imaging for Non-Medical Applications,” Published Technical Disclosure No. 24-11857164_0002_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11857164_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,164.

Summary of the Inventive Concept

The inventive concept applies the core technology of fluorescence-based imaging to novel applications beyond medical imaging, including crop health monitoring, food processing, solar panel inspection, water quality monitoring, and environmental biomarker detection.

Background and Problem Solved

The original patent disclosed a method, image processor, and device for observing live tissue containing a bolus of a fluorophore, primarily for neurosurgical applications. However, the limitations of this technology are its narrow focus on medical imaging and its inability to address diverse problems in other industries. The new inventive concept tackles this limitation by adapting the core technology to address pressing issues in various non-medical fields.

Detailed Description of the Inventive Concept

The new inventive concept comprises a camera system capturing multi- or hyperspectral images, an illumination system emitting fluorescence excitation wavelengths, and an image processor analyzing the images to detect fluorophores indicative of specific conditions. In crop health monitoring, the system detects fluorophores indicating plant stress. In food processing, the method identifies fluorophores indicative of contamination. In solar panel inspection, the device detects fluorophores indicating defects or degradation. In water quality monitoring, the system detects fluorophores indicating pollutants or contaminants. In environmental biomarker detection, the method identifies fluorophores indicative of specific biomarkers.

Novelty and Inventive Step

The new claims introduce a paradigm shift by applying the fluorescence-based imaging technology to entirely new industries and problem domains, demonstrating a non-obvious and innovative extension of the original patent's core technology.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include adapting the camera system for specific wavelengths, modifying the illumination system for increased efficiency, or developing new image processing algorithms for improved fluorophore detection. Variations of the inventive concept could involve integrating the technology with existing systems, such as drones for crop monitoring or robotic arms for food processing inspection.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in various industries, including agriculture, food processing, renewable energy, environmental monitoring, and biotechnology. The target market includes companies and organizations seeking innovative solutions for monitoring and detecting specific conditions in their respective fields.

CPC Classifications

SectionClassGroup
A A61 A61B1/043
A A61 A61B1/00004
G G06 G06T7/0016
G G06 G06T11/001
A A61 A61B2017/00066
G G06 G06T2207/10016
G G06 G06T2207/10064
G G06 G06T2207/30101
G G06 G06T2207/30104
G G06 G06T2210/41

Field of Art

Imaging and signal processing technologies with expertise in multi-spectral image analysis, fluorescence detection, and cross-domain sensor applications spanning medical, environmental, and industrial inspection domains

Person of Ordinary Skill (PHOSITA) Profile

A skilled practitioner with advanced degrees in electrical engineering, computer vision, or biomedical engineering, possessing comprehensive knowledge of image processing algorithms, spectral imaging techniques, and interdisciplinary sensor design

Obviousness Rationale

A person having ordinary skill would recognize the fundamental technical transferability of the source patent's fluorescence imaging methodology across diverse application domains. The core technological principles of spectral image capture, fluorophore detection, and signal processing remain consistent regardless of the specific inspection context. The PTD demonstrates predictable extensions of the original patent's core technological framework by applying identical signal processing and imaging techniques to alternative problem domains.

Obvious Combinations & Variations

Source Patent Element
Method for detecting fluorophore intensity through iterative signal processing and component signal decomposition
PTD Variation
Applying identical signal processing techniques to detect fluorophores indicating crop stress, solar panel degradation, or environmental contaminants
Obviousness Reasoning
Predictable application of known image processing technique to alternative domains with substantially similar technical requirements
Source Patent Element
Threshold-based fluorescence signal detection methodology
PTD Variation
Extending threshold detection to identify fluorophores across non-medical inspection scenarios like food processing and water quality monitoring
Obviousness Reasoning
Known technique of signal threshold filtering can be trivially adapted across different sensing contexts with minimal technical modification
Source Patent Element
Hyperspectral imaging system for capturing multi-wavelength fluorescence data
PTD Variation
Repurposing hyperspectral imaging hardware for environmental, agricultural, and industrial inspection applications
Obviousness Reasoning
Sensor hardware remains functionally equivalent across domains, representing an obvious design adaptation for a skilled practitioner
Source Patent Element
Component signal weighting and selection algorithms
PTD Variation
Applying identical signal processing techniques to extract meaningful fluorescence signatures in non-medical contexts
Obviousness Reasoning
Mathematical signal processing approaches are universally applicable across sensing domains with predictable computational outcomes
Source Patent Element
Illumination system for fluorescence excitation
PTD Variation
Modifying excitation wavelengths and illumination parameters for alternative inspection scenarios
Obviousness Reasoning
Routine engineering optimization representing a predictable variation within a skilled practitioner's technical capabilities
35 U.S.C. § 103 Summary: Based on US Patent 11857164's comprehensive fluorescence imaging methodology, the present publication demonstrates that the claimed variations represent obvious extensions of prior art through predictable technological adaptation. A person having ordinary skill would recognize the fundamental technical equivalence of the disclosed imaging approaches across diverse application domains, rendering subsequent claims involving similar signal processing techniques prima facie obvious.

Original Patent Information

Patent NumberUS 11,857,164
TitleMethod, image processor and device for observing an object containing a bolus of a fluorophore
Assignee(s)Leica Instruments (Singapore) Pte Ltd.