Next-Generation Clot Removal System with AI-Enabled Micro-Agents

Publication ID: 24-11857210_0010_PTD
Published: November 07, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Next-Generation Clot Removal System with AI-Enabled Micro-Agents,” Published Technical Disclosure No. 24-11857210_0010_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11857210_0010_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,210.

Summary of the Inventive Concept

A revolutionary clot removal system leveraging nanorobotics, AI-driven navigation, and bio-inspired materials to enable minimally invasive, real-time clot monitoring and removal, potentially replacing traditional thrombectomy devices.

Background and Problem Solved

The original patent for clot retrieval devices, while effective, has limitations in terms of invasiveness, clot engagement, and real-time monitoring. The new inventive concept addresses these limitations by introducing AI-enabled micro-agents, swarm robotics, and self-healing materials to provide a more effective, minimally invasive, and real-time clot removal solution.

Detailed Description of the Inventive Concept

The next-generation clot removal system comprises a nanorobot-enabled clot retrieval device with a swarm of micro-agents that can be deployed to a blood vessel to break down and remove a clot. The micro-agents are equipped with nanoscale propellers and clot-digesting enzymes, guided by a neural network-based navigation system that facilitates real-time clot monitoring. The system also includes a wearable, non-invasive brain-computer interface for detecting ischemic stroke or pulmonary embolism in real-time, triggering the deployment of the clot removal device. Additionally, the system can be integrated with machine learning algorithms to analyze patient medical history and detect risk factors for thromboembolism, enabling prophylactic clot prevention.

Novelty and Inventive Step

The new claims introduce the use of nanorobotics, swarm robotics, AI-driven navigation, and bio-inspired materials, which are not present in the original patent. These innovations provide a paradigm shift in clot removal technology, enabling minimally invasive, real-time clot monitoring and removal, and potentially making traditional thrombectomy devices obsolete.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different types of micro-agents, such as those equipped with ultrasound or optical sensors for enhanced clot detection. Variations could also include the integration of the system with other medical devices, such as stents or catheters, to provide a comprehensive vascular intervention platform.

Potential Commercial Applications and Market

The next-generation clot removal system has significant commercial potential in the medical device industry, particularly in the areas of stroke and pulmonary embolism treatment. The system's minimally invasive nature, real-time clot monitoring capabilities, and potential for prophylactic clot prevention make it an attractive solution for hospitals, clinics, and medical research institutions.

CPC Classifications

SectionClassGroup
A A61 A61B17/221
A A61 A61B90/39
A A61 A61F2/013
A A61 A61B17/320725
A A61 A61B2017/00867
A A61 A61B2017/2215
A A61 A61B2017/2217
A A61 A61B2017/22034
A A61 A61B2017/22079
A A61 A61B2017/22094
A A61 A61B2090/3966
A A61 A61F2002/016
A A61 A61F2230/008
A A61 A61F2230/0091

Field of Art

Medical device engineering, specifically interventional neurovascular and thrombectomy technologies, involving advanced medical device design, minimally invasive surgical techniques, and biomedical engineering with expertise in vascular intervention systems

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device designer with advanced degrees in bioengineering, experience in interventional medical technologies, knowledge of nanotechnology, robotics, and neural network applications in medical devices, and understanding of vascular pathology and clot removal mechanisms

Obviousness Rationale

A PHOSITA would recognize that the PTD's nanorobot-enabled clot removal system represents a predictable technological progression from the source patent's clot retrieval device, utilizing known engineering principles of miniaturization, swarm robotics, and AI-guided navigation to enhance existing clot removal methodologies. The core functional requirements of clot engagement, vessel navigation, and targeted removal remain consistent between the source patent and PTD, with the variations representing incremental technological improvements using well-established engineering techniques. The integration of neural network guidance and micro-agent swarm technologies would be considered an obvious extension of existing medical device design principles.

Obvious Combinations & Variations

Source Patent Element
Expandable structure with configurable deployment modes for clot engagement
PTD Variation
Nanorobot swarm with micro-agents capable of dynamic reconfiguration and targeted clot interaction
Obviousness Reasoning
A PHOSITA would recognize that replacing a macro-scale expandable structure with a swarm of micro-agents represents a predictable miniaturization strategy using known robotics and nanotechnology principles
Source Patent Element
Clot pinching configuration with variable radial force
PTD Variation
Micro-agents equipped with clot-digesting enzymes and nanoscale propellers for targeted clot breakdown
Obviousness Reasoning
Enzymatic clot dissolution is a known medical technique, and integrating this with micro-robotic delivery represents an obvious combination of established medical intervention strategies
Source Patent Element
Device configured for vessel-based clot removal
PTD Variation
AI-driven neural network navigation system for real-time clot monitoring and intervention
Obviousness Reasoning
Incorporating machine learning and adaptive navigation into medical devices is a predictable technological progression, representing an obvious enhancement to existing clot removal methodologies
Source Patent Element
Mechanical clot retrieval device with configurable sections
PTD Variation
Bio-inspired, self-healing material that can conform to vessel walls and release enzymes in a controlled manner
Obviousness Reasoning
Material science innovations in medical devices, particularly adaptive and responsive materials, represent a known and predictable approach to improving device performance and patient outcomes
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857210 and the published technical disclosure, a person having ordinary skill in the art would find the claimed innovations of a nanorobot-enabled clot removal system with AI-guided micro-agents to be obvious variations of existing clot retrieval technologies. The disclosed variations represent predictable technological extensions utilizing known engineering principles of miniaturization, adaptive robotics, and neural network guidance, thereby rendering potential patent claims in this domain obvious and non-patentable under 35 U.S.C. Section 103.

Original Patent Information

Patent NumberUS 11,857,210
TitleClot retrieval device for removing clot from a blood vessel
Assignee(s)Neuravi Limited