Intelligent Cryogenic Tissue Remodeling System

Publication ID: 24-11857239_0005_PTD
Published: November 07, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Intelligent Cryogenic Tissue Remodeling System,” Published Technical Disclosure No. 24-11857239_0005_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11857239_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,239.

Summary of the Inventive Concept

An advanced cryogenic system that utilizes real-time tissue impedance measurements, nanofluidics, and micro-sensors to dynamically adjust the cooling zone, enabling precise and minimally invasive tissue remodeling for a wide range of cosmetic and therapeutic applications.

Background and Problem Solved

The original patent, 'Cryogenic needle with freeze zone regulation,' provided a significant advancement in cryogenic tissue remodeling. However, it had limitations in terms of precision, control, and adaptability to varying tissue types and conditions. The new inventive concept addresses these limitations by introducing real-time tissue impedance measurements, advanced fluid delivery systems, and integrated micro-sensors, enabling a more targeted and effective treatment approach.

Detailed Description of the Inventive Concept

The Intelligent Cryogenic Tissue Remodeling System consists of a cryogenic needle with a built-in freeze zone regulation module, which dynamically adjusts the cooling zone based on real-time tissue impedance measurements. The system also incorporates a nanofluidics and microfluidics-based cryogenic fluid delivery module, allowing for highly localized and controlled cooling. Additionally, the system features a micro-sensor array that detects and responds to changes in tissue temperature, impedance, and hydration levels, providing real-time feedback for optimizing treatment parameters. This integrated system enables the creation of three-dimensional tissue matrices that reinforce target tissue structure, improve skin elasticity, and reduce wrinkles, as well as the selective targeting and destruction of diseased tissue cells while preserving healthy surrounding tissue.

Novelty and Inventive Step

The new claims introduce several novel and non-obvious features, including the use of real-time tissue impedance measurements, nanofluidics and microfluidics-based cryogenic fluid delivery, and integrated micro-sensors. These advancements enable a level of precision, control, and adaptability that was not possible with the original patent, and thus represent a significant inventive step forward.

Alternative Embodiments and Variations

Alternative embodiments of the Intelligent Cryogenic Tissue Remodeling System could include the use of different types of sensors, such as optical or acoustic sensors, or the integration of additional treatment modalities, such as ultrasound or electromagnetic energy. Variations could also include the development of specialized cryogenic needles for specific tissue types or applications, such as dermatological or oncological treatments.

Potential Commercial Applications and Market

The Intelligent Cryogenic Tissue Remodeling System has significant commercial potential in the cosmetic and therapeutic industries, with potential applications in skin rejuvenation, wrinkle reduction, and the treatment of skin lesions and diseases. The system's ability to provide precise and minimally invasive treatments could also make it an attractive option for patients seeking to avoid more invasive surgical procedures.

CPC Classifications

SectionClassGroup
A A61 A61B18/02
A A61 A61B2017/00473
A A61 A61B2018/00029
A A61 A61B2018/00041
A A61 A61B2018/00648
A A61 A61B2018/00714
A A61 A61B2018/00738
A A61 A61B2018/00744
A A61 A61B2018/00779
A A61 A61B2018/00791
A A61 A61B2018/00898
A A61 A61B2018/00994
A A61 A61B2018/0262
A A61 A61B2018/0293

Original Patent Information

Patent NumberUS 11,857,239
TitleCryogenic needle with freeze zone regulation
Assignee(s)Pacira CryoTech, Inc.