Intelligent Cryogenic Tissue Remodeling System

Publication ID: 24-11857239_0005_PTD
Published: November 07, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Intelligent Cryogenic Tissue Remodeling System,” Published Technical Disclosure No. 24-11857239_0005_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11857239_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,239.

Summary of the Inventive Concept

An advanced cryogenic system that utilizes real-time tissue impedance measurements, nanofluidics, and micro-sensors to dynamically adjust the cooling zone, enabling precise and minimally invasive tissue remodeling for a wide range of cosmetic and therapeutic applications.

Background and Problem Solved

The original patent, 'Cryogenic needle with freeze zone regulation,' provided a significant advancement in cryogenic tissue remodeling. However, it had limitations in terms of precision, control, and adaptability to varying tissue types and conditions. The new inventive concept addresses these limitations by introducing real-time tissue impedance measurements, advanced fluid delivery systems, and integrated micro-sensors, enabling a more targeted and effective treatment approach.

Detailed Description of the Inventive Concept

The Intelligent Cryogenic Tissue Remodeling System consists of a cryogenic needle with a built-in freeze zone regulation module, which dynamically adjusts the cooling zone based on real-time tissue impedance measurements. The system also incorporates a nanofluidics and microfluidics-based cryogenic fluid delivery module, allowing for highly localized and controlled cooling. Additionally, the system features a micro-sensor array that detects and responds to changes in tissue temperature, impedance, and hydration levels, providing real-time feedback for optimizing treatment parameters. This integrated system enables the creation of three-dimensional tissue matrices that reinforce target tissue structure, improve skin elasticity, and reduce wrinkles, as well as the selective targeting and destruction of diseased tissue cells while preserving healthy surrounding tissue.

Novelty and Inventive Step

The new claims introduce several novel and non-obvious features, including the use of real-time tissue impedance measurements, nanofluidics and microfluidics-based cryogenic fluid delivery, and integrated micro-sensors. These advancements enable a level of precision, control, and adaptability that was not possible with the original patent, and thus represent a significant inventive step forward.

Alternative Embodiments and Variations

Alternative embodiments of the Intelligent Cryogenic Tissue Remodeling System could include the use of different types of sensors, such as optical or acoustic sensors, or the integration of additional treatment modalities, such as ultrasound or electromagnetic energy. Variations could also include the development of specialized cryogenic needles for specific tissue types or applications, such as dermatological or oncological treatments.

Potential Commercial Applications and Market

The Intelligent Cryogenic Tissue Remodeling System has significant commercial potential in the cosmetic and therapeutic industries, with potential applications in skin rejuvenation, wrinkle reduction, and the treatment of skin lesions and diseases. The system's ability to provide precise and minimally invasive treatments could also make it an attractive option for patients seeking to avoid more invasive surgical procedures.

CPC Classifications

SectionClassGroup
A A61 A61B18/02
A A61 A61B2017/00473
A A61 A61B2018/00029
A A61 A61B2018/00041
A A61 A61B2018/00648
A A61 A61B2018/00714
A A61 A61B2018/00738
A A61 A61B2018/00744
A A61 A61B2018/00779
A A61 A61B2018/00791
A A61 A61B2018/00898
A A61 A61B2018/00994
A A61 A61B2018/0262
A A61 A61B2018/0293

Field of Art

Medical device technologies for cryogenic tissue treatment, specifically focusing on dermatological and cosmetic interventions involving precision cooling systems with temperature and fluid regulation

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device designer with expertise in cryogenic technologies, microfluidics, sensor integration, and tissue remodeling techniques, possessing advanced knowledge of thermal control systems and minimally invasive medical interventions

Obviousness Rationale

A PHOSITA would recognize that the PTD's disclosed variations represent predictable technological extensions of the source patent's core cryogenic needle technology. The additional elements like tissue impedance measurement, nanofluidic control, and micro-sensor integration are logical incremental improvements that address known limitations in precise tissue cooling. These variations demonstrate standard engineering problem-solving approaches within the established technological framework of cryogenic medical devices.

Obvious Combinations & Variations

Source Patent Element
Needle probe with coolant supply system regulated by a valve for controlling cooling zone
PTD Variation
Integrating real-time tissue impedance measurements to dynamically adjust coolant flow and cooling zone parameters
Obviousness Reasoning
A PHOSITA would find it obvious to enhance valve regulation with feedback mechanisms, as sensor-based adaptive control is a standard technique for improving precision in medical device technologies
Source Patent Element
Method for maintaining cooling zone within allowable size tolerance
PTD Variation
Implementing nanofluidics and microfluidics for more granular and localized cooling zone management
Obviousness Reasoning
Applying advanced fluid control techniques to improve existing cooling zone regulation represents a predictable technological progression using known microfluidic design principles
Source Patent Element
Cryogenic needle for tissue remodeling with temperature monitoring
PTD Variation
Adding multi-parameter micro-sensor array to detect temperature, impedance, and hydration levels
Obviousness Reasoning
Expanding sensor capabilities to provide more comprehensive tissue characterization is an obvious design optimization that leverages standard sensor integration techniques
Source Patent Element
Method for cryogenically treating target tissue
PTD Variation
Creating three-dimensional tissue matrices with controlled ice crystal lattice structures for selective tissue treatment
Obviousness Reasoning
Developing more precise tissue interaction strategies using known crystallization principles represents a logical extension of existing cryogenic treatment methodologies
Source Patent Element
Cosmetic tissue remodeling using cryogenic cooling
PTD Variation
Implementing targeted cellular-level tissue restructuring with minimal surrounding tissue damage
Obviousness Reasoning
Refining treatment specificity through advanced cooling techniques is a predictable technological improvement addressing known limitations in existing cryogenic interventions
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857239 and the disclosed technological variations, a person having ordinary skill in the art would find the claimed innovations of the Intelligent Cryogenic Tissue Remodeling System to be obvious extensions of existing cryogenic medical device technologies. The incremental improvements in sensor integration, fluid control, and tissue interaction represent standard engineering problem-solving approaches that do not rise to the level of non-obvious invention.

Original Patent Information

Patent NumberUS 11,857,239
TitleCryogenic needle with freeze zone regulation
Assignee(s)Pacira CryoTech, Inc.