Advanced Cryosurgical Systems with Real-time Tissue Impedance Feedback

Publication ID: 24-11857240_0010_PTD

Published: November 07, 2025

Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Advanced Cryosurgical Systems with Real-time Tissue Impedance Feedback,” Published Technical Disclosure No. 24-11857240_0010_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11857240_0010_PTD

This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,240.

Summary of the Inventive Concept

The present invention discloses a next-generation cryosurgical system that integrates real-time tissue impedance measurements, dynamic thermal management, and advanced electrolysis capabilities to enable more precise and effective treatments.

Background and Problem Solved

The original patent described a cryosurgical instrument combining cryosurgery and electrolysis treatments. However, it lacked real-time feedback mechanisms to optimize treatment parameters. The present invention addresses this limitation by incorporating real-time tissue impedance measurements, enabling dynamic adjustments to the cryosurgical probe's temperature and electrolysis parameters.

Detailed Description of the Inventive Concept

The advanced cryosurgical system comprises a cryosurgical probe, an electrolysis module, a thermal management module, and a machine learning module. The thermal management module dynamically adjusts the cryosurgical probe's temperature in response to real-time tissue impedance measurements. The machine learning module predicts optimal cryosurgical and electrolysis parameters based on real-time tissue impedance measurements and patient-specific data. This integration enables more precise and effective treatments, reducing the risk of tissue damage and improving patient outcomes.

Novelty and Inventive Step

The novel aspect of the present invention lies in the integration of real-time tissue impedance measurements with dynamic thermal management and advanced electrolysis capabilities. This allows for unprecedented precision and control in cryosurgical treatments, making the original inventive concept obsolete.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include using different types of sensors to measure tissue impedance, incorporating additional feedback mechanisms, or integrating the system with other medical devices. Variations could also include using the system for different medical applications, such as dermatology or oncology.

Potential Commercial Applications and Market

The advanced cryosurgical system has significant commercial potential in the medical device industry, particularly in the fields of cryosurgery, dermatology, and oncology. The system's ability to provide more precise and effective treatments could lead to increased adoption and market share, with potential applications in hospitals, clinics, and research institutions.

CPC Classifications

Section	Class	Group
A	A61	A61B18/02
A	A61	A61B2017/00097
A	A61	A61B2018/00101
A	A61	A61B2018/0262

Section 103 Obviousness Analysis (PHOSITA)

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Field of Art

Medical device technologies for minimally invasive surgical interventions, specifically cryosurgical and electrolysis systems with a focus on thermal management and tissue treatment techniques

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device designer with expertise in thermoelectric cooling, electrosurgical technologies, and advanced medical instrumentation, holding at least a master's degree with 3-5 years of specialized experience in surgical probe design

Obviousness Rationale

A PHOSITA would recognize that integrating real-time tissue impedance feedback with cryosurgical and electrolysis systems represents a predictable technological advancement in medical device design. The source patent's foundational teachings of combined cryosurgery and electrolysis naturally suggest opportunities for enhanced control and precision through dynamic parameter adjustment. The proposed variations leverage standard engineering techniques of sensor integration, feedback loops, and machine learning to incrementally improve the existing technological framework.

Obvious Combinations & Variations

Source Patent Element

Cryosurgical probe with integrated electrode for electrolysis

PTD Variation

Adding real-time tissue impedance measurement and dynamic thermal management

Obviousness Reasoning

Implementing sensor-based feedback is a known technique in medical device design, representing a predictable optimization of existing technological concepts

Source Patent Element

Electrode fastened to exterior surface of cryosurgical probe

PTD Variation

Incorporating microcontroller to dynamically adjust thermoelectric cooling based on impedance measurements

Obviousness Reasoning

Adaptive control systems are standard engineering practice, and integrating computational management represents an obvious extension of existing probe technologies

Source Patent Element

Cryosurgical instrument with protective thermal conductive member

PTD Variation

Machine learning module predicting optimal treatment parameters from impedance and patient data

Obviousness Reasoning

Applying machine learning to medical device optimization is a well-established approach, representing a logical progression of existing technological capabilities

Source Patent Element

Combination cryosurgery and electrolysis treatment method

PTD Variation

Dynamic parameter adjustment using real-time tissue response measurements

Obviousness Reasoning

Closed-loop feedback systems are fundamental to precision medical technologies, making this variation an obvious design improvement

Source Patent Element

Electrolysis electrode integrated with cryosurgical probe

PTD Variation

Expanding system to include multiple sensor types and cross-domain data integration

Obviousness Reasoning

Multimodal sensing and data fusion are standard techniques in advanced medical device engineering

35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857240 and the disclosed technological variations, a person of ordinary skill in the art would find the claimed innovations obvious and anticipated. The published technical disclosure demonstrates that the proposed advancements represent predictable incremental improvements achievable through standard engineering practices, thereby rendering subsequent claims of novelty invalid under 35 U.S.C. Section 103.

Original Patent Information

Patent Number	US 11,857,240
Title	Methods, systems, and apparatuses for cryosurgery, coldsurgery, and electrolysis
Assignee(s)	CRYOELECTRIC SCIENCE LTD.