Published Technical Disclosure Archive

Adaptive Tissue Ablation Systems for Personalized Electroporation

Publication ID: 24-11857244_0005_PTD
Published: November 07, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Adaptive Tissue Ablation Systems for Personalized Electroporation,” Published Technical Disclosure No. 24-11857244_0005_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11857244_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,244.

Summary of the Inventive Concept

The present inventive concept discloses advanced tissue ablation systems that integrate real-time monitoring, adaptive frequency modulation, and personalized pulse sequences to achieve optimized electroporation outcomes.

Background and Problem Solved

The original patent disclosed methods and systems for tissue ablation using pulse shape designs, which have limitations in terms of fixed pulse sequences and lack of real-time monitoring. The present inventive concept addresses these limitations by introducing adaptive frequency modulation, 3D mapping, and real-time monitoring to ensure precise and personalized tissue ablation.

Detailed Description of the Inventive Concept

The new inventive concept comprises a system for tissue ablation that includes a pulse generator with adaptive frequency modulation, a 3D mapping module, and a sensor array for real-time monitoring of tissue impedance, temperature, and electrical conductivity. The system generates a customized pulse sequence based on the 3D map and adjusts it in real-time according to the detected changes in tissue properties. This allows for optimized electroporation outcomes, reduced treatment time, and minimized side effects.

Novelty and Inventive Step

The present inventive concept introduces a paradigm shift in tissue ablation by integrating real-time monitoring, adaptive frequency modulation, and personalized pulse sequences, which is a significant departure from the fixed pulse sequences of the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of machine learning algorithms to predict optimal pulse sequences, the integration of multiple sensing modalities, or the development of implantable devices for chronic tissue ablation.

Potential Commercial Applications and Market

The present inventive concept has significant commercial potential in the medical device industry, particularly in the fields of cancer treatment, cardiac ablation, and cosmetic dermatology. The market for tissue ablation devices is expected to grow significantly in the next decade, driven by the increasing demand for minimally invasive procedures and personalized medicine.

CPC Classifications

SectionClassGroup
A A61 A61B18/1206
A A61 A61B18/1402
A A61 A61N1/205
A A61 A61N1/327
A A61 A61B5/14539
A A61 A61B2018/00577
A A61 A61B2018/00613
A A61 A61B2018/00827
A A61 A61B2018/00994
A A61 A61B2018/1266
A A61 A61B2018/1472

Field of Art

Biomedical engineering, specifically electrosurgical tissue ablation technologies, focusing on pulse-based electroporation techniques for minimally invasive medical interventions

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device researcher with expertise in electrical pulse generation, tissue interaction physics, sensor technologies, and advanced medical instrumentation design, typically holding a PhD or equivalent professional experience in biomedical engineering or medical device development

Obviousness Rationale

A PHOSITA would recognize that the PTD represents a natural progression of the source patent's electroporation techniques by introducing adaptive pulse generation and real-time monitoring technologies. The core principles of tissue ablation using electrical pulses remain consistent, with the PTD merely extending the original concept through predictable technological enhancements in sensing, mapping, and pulse modulation. These variations represent standard engineering approaches to improving medical device performance through intelligent feedback and personalization strategies.

Obvious Combinations & Variations

Source Patent Element
Pulse delivery method with exponential decay falling edge for tissue electroporation
PTD Variation
Adaptive frequency modulation of pulse sequences based on real-time tissue impedance monitoring
Obviousness Reasoning
A PHOSITA would find it obvious to dynamically adjust pulse characteristics using feedback mechanisms, as sensor-driven pulse optimization is a known technique in electrical medical interventions
Source Patent Element
Fixed pulse sequence for tissue treatment
PTD Variation
3D mapping and personalized pulse sequence generation based on tissue electrical conductivity variations
Obviousness Reasoning
Customizing treatment parameters based on tissue-specific characteristics represents a predictable design optimization approach within medical device engineering
Source Patent Element
Electroporation method using electrode interfaces
PTD Variation
Multi-electrode array with individually addressable electrodes delivering unique pulse shapes
Obviousness Reasoning
Spatially-aware electrode configurations are a standard engineering solution for improving localized tissue treatment precision
Source Patent Element
Basic electroporation pulse delivery mechanism
PTD Variation
Machine learning algorithms for predicting optimal pulse sequences through computational simulation
Obviousness Reasoning
Applying computational modeling and machine learning to medical device optimization represents a routine technological enhancement for a skilled practitioner
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857244 and the disclosed technological variations, a person of ordinary skill in the art would find the claimed innovations of personalized tissue ablation systems with adaptive pulse generation and real-time monitoring to be obvious extensions of existing electroporation methodologies, thereby rendering such claims unpatentable under 35 U.S.C. Section 103 as predictable variations within the established technological domain of electrical tissue ablation techniques.

Original Patent Information

Patent NumberUS 11,857,244
TitleMethods, systems, and apparatuses for tissue ablation using pulse shape designs
Assignee(s)RM2 TECHNOLOGY LLC, Inter Science GmbH