Electroporation-based Solutions for Diverse Industries
Legal Citation
Summary of the Inventive Concept
The inventive concept leverages the core technology of pulse shape designs for tissue ablation to develop innovative solutions for water purification, food sterilization, cosmetic skin treatment, biofilm removal, and wound healing.
Background and Problem Solved
The original patent disclosed methods, systems, and apparatuses for tissue ablation using pulse shape designs. However, the limitations of the original patent lie in its narrow focus on tissue ablation. The inventive concept addresses this limitation by exploring new applications and use cases for the core technology, thereby expanding its potential impact.
Detailed Description of the Inventive Concept
The inventive concept involves the application of pulse shape designs to induce electroporation in various contexts. In water purification, the pulses are designed to inactivate waterborne pathogens. For food sterilization, the pulses target microorganisms present on the food product. In cosmetic skin treatment, the pulses enhance skin permeability and facilitate transdermal delivery of cosmetic agents. In biofilm removal, the pulses disrupt the biofilm and facilitate its removal. Lastly, in wound healing, the pulses enhance wound healing and tissue regeneration.
Novelty and Inventive Step
The novelty of the inventive concept lies in its application of pulse shape designs to entirely new industries and fields, which was not originally considered in the original patent. The inventive step is the recognition of the potential of the core technology to be adapted and modified for diverse applications.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include the use of different pulse shapes, frequencies, or amplitudes to achieve the desired electroporation effects. Variations could also involve the integration of the pulse shape designs with existing technologies or systems in each of the target industries.
Potential Commercial Applications and Market
The inventive concept has significant commercial potential in various industries, including water treatment, food processing, cosmetics, healthcare, and biomedical devices. The target market includes companies and organizations seeking innovative solutions for water purification, food safety, skin care, biofilm removal, and wound healing.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61B18/1206 |
| A | A61 | A61B18/1402 |
| A | A61 | A61N1/205 |
| A | A61 | A61N1/327 |
| A | A61 | A61B5/14539 |
| A | A61 | A61B2018/00577 |
| A | A61 | A61B2018/00613 |
| A | A61 | A61B2018/00827 |
| A | A61 | A61B2018/00994 |
| A | A61 | A61B2018/1266 |
| A | A61 | A61B2018/1472 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Biomedical engineering and electrophysiological technologies, specifically focused on pulse-based interventions for tissue manipulation, with expertise in electroporation techniques, pulse generation, and biomedical applications across medical, pharmaceutical, and industrial domains
Person of Ordinary Skill (PHOSITA) Profile
A skilled practitioner with advanced degrees in bioengineering, electrical engineering, or medical physics, possessing comprehensive knowledge of electroporation mechanisms, pulse shape design, and cross-disciplinary applications of electrical pulse technologies
Obviousness Rationale
A PHOSITA would recognize the fundamental principles of electroporation disclosed in US 11857244 are universally applicable across multiple domains, with pulse shape characteristics being adaptable to different target tissues and objectives. The exponential decay falling edge and controlled pulse parameters represent a generalizable technique that can be systematically translated between biological and industrial contexts. The core technological insight of using precisely controlled electrical pulses to induce membrane permeabilization is inherently extensible beyond the original tissue ablation context.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,244 |
|---|---|
| Title | Methods, systems, and apparatuses for tissue ablation using pulse shape designs |
| Assignee(s) | RM2 TECHNOLOGY LLC, Inter Science GmbH |