Electroporation-based Solutions for Diverse Industries

Publication ID: 24-11857244_0007_PTD
Published: November 07, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Electroporation-based Solutions for Diverse Industries,” Published Technical Disclosure No. 24-11857244_0007_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11857244_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,244.

Summary of the Inventive Concept

The inventive concept leverages the core technology of pulse shape designs for tissue ablation to develop innovative solutions for water purification, food sterilization, cosmetic skin treatment, biofilm removal, and wound healing.

Background and Problem Solved

The original patent disclosed methods, systems, and apparatuses for tissue ablation using pulse shape designs. However, the limitations of the original patent lie in its narrow focus on tissue ablation. The inventive concept addresses this limitation by exploring new applications and use cases for the core technology, thereby expanding its potential impact.

Detailed Description of the Inventive Concept

The inventive concept involves the application of pulse shape designs to induce electroporation in various contexts. In water purification, the pulses are designed to inactivate waterborne pathogens. For food sterilization, the pulses target microorganisms present on the food product. In cosmetic skin treatment, the pulses enhance skin permeability and facilitate transdermal delivery of cosmetic agents. In biofilm removal, the pulses disrupt the biofilm and facilitate its removal. Lastly, in wound healing, the pulses enhance wound healing and tissue regeneration.

Novelty and Inventive Step

The novelty of the inventive concept lies in its application of pulse shape designs to entirely new industries and fields, which was not originally considered in the original patent. The inventive step is the recognition of the potential of the core technology to be adapted and modified for diverse applications.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different pulse shapes, frequencies, or amplitudes to achieve the desired electroporation effects. Variations could also involve the integration of the pulse shape designs with existing technologies or systems in each of the target industries.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in various industries, including water treatment, food processing, cosmetics, healthcare, and biomedical devices. The target market includes companies and organizations seeking innovative solutions for water purification, food safety, skin care, biofilm removal, and wound healing.

CPC Classifications

SectionClassGroup
A A61 A61B18/1206
A A61 A61B18/1402
A A61 A61N1/205
A A61 A61N1/327
A A61 A61B5/14539
A A61 A61B2018/00577
A A61 A61B2018/00613
A A61 A61B2018/00827
A A61 A61B2018/00994
A A61 A61B2018/1266
A A61 A61B2018/1472

Field of Art

Biomedical engineering and electrophysiological technologies, specifically focused on pulse-based interventions for tissue manipulation, with expertise in electroporation techniques, pulse generation, and biomedical applications across medical, pharmaceutical, and industrial domains

Person of Ordinary Skill (PHOSITA) Profile

A skilled practitioner with advanced degrees in bioengineering, electrical engineering, or medical physics, possessing comprehensive knowledge of electroporation mechanisms, pulse shape design, and cross-disciplinary applications of electrical pulse technologies

Obviousness Rationale

A PHOSITA would recognize the fundamental principles of electroporation disclosed in US 11857244 are universally applicable across multiple domains, with pulse shape characteristics being adaptable to different target tissues and objectives. The exponential decay falling edge and controlled pulse parameters represent a generalizable technique that can be systematically translated between biological and industrial contexts. The core technological insight of using precisely controlled electrical pulses to induce membrane permeabilization is inherently extensible beyond the original tissue ablation context.

Obvious Combinations & Variations

Source Patent Element
Pulse with exponential decay falling edge for inducing electroporation in tissue
PTD Variation
Applying identical pulse characteristics to inactivate waterborne pathogens in water purification systems
Obviousness Reasoning
Known technique of using electroporation for cellular disruption, with predictable results when applied to microbial targets across different environments
Source Patent Element
Controlled pulse magnitude and duration for targeted cellular effects
PTD Variation
Modifying pulse parameters to enhance skin permeability for cosmetic transdermal delivery
Obviousness Reasoning
Finite set of identifiable solutions for manipulating cellular membranes, with pulse shape being a design choice based on established electrophysiological principles
Source Patent Element
Reversible and irreversible electroporation techniques
PTD Variation
Adapting pulse design for biofilm disruption and microorganism inactivation in food sterilization
Obviousness Reasoning
Predictable extension of known electroporation mechanisms to alternative biological targets, representing a straightforward technological translation
Source Patent Element
Pulse generation with specific rising edge, plateau, and falling edge characteristics
PTD Variation
Implementing pulse designs for wound healing and tissue regeneration applications
Obviousness Reasoning
Well-understood electrical intervention technique with demonstrable potential for cellular stimulation across different biological contexts
35 U.S.C. § 103 Summary: Based on the teachings of US 11857244, a person having ordinary skill in the art would find the variations disclosed in the Published Technical Disclosure obvious and anticipated, as the fundamental pulse shape design principles represent a generalizable approach to electroporation that can be systematically applied across diverse technological domains without requiring inventive complexity or non-obvious technological leaps.

Original Patent Information

Patent NumberUS 11,857,244
TitleMethods, systems, and apparatuses for tissue ablation using pulse shape designs
Assignee(s)RM2 TECHNOLOGY LLC, Inter Science GmbH