Personalized Neuromodulation Systems with Adaptive Stimulation

Publication ID: 24-11857275_0006_PTD
Published: November 07, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Personalized Neuromodulation Systems with Adaptive Stimulation,” Published Technical Disclosure No. 24-11857275_0006_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11857275_0006_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,275.

Summary of the Inventive Concept

A neuromodulation system that uses machine learning and real-time brain activity analysis to personalize and optimize brain stimulation therapy for individual patients, improving treatment outcomes and reducing side effects.

Background and Problem Solved

The original patent for targeted neuromodulation systems had limitations in terms of stimulation frequency, intensity, and target selection. The new inventive concept addresses these limitations by incorporating machine learning algorithms, real-time brain activity analysis, and adaptive stimulation to provide more effective and personalized treatment for patients with mental conditions.

Detailed Description of the Inventive Concept

The new inventive concept consists of a neuromodulation system with a processor and memory containing a targeting application. The targeting application uses machine learning algorithms to analyze patient brain data and stimulation response history to identify a patient-specific optimal stimulation frequency and intensity. The system can adjust stimulation intensity in real-time based on the patient's brain activity and stimulation response. Additionally, the system can generate a 3D model of the patient's brain and identify stimulation targets within the model. The machine learning algorithm can be trained on a dataset of brain activity and stimulation response from a plurality of patients, enabling the system to learn from experience and improve treatment outcomes.

Novelty and Inventive Step

The new inventive concept's use of machine learning algorithms to personalize stimulation frequency and intensity, combined with real-time brain activity analysis and adaptive stimulation, represents a significant improvement over the original patent. The incorporation of a 3D brain model and stimulation target identification within the model is also a novel aspect of the invention.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include using different machine learning algorithms, such as deep learning neural networks, or incorporating additional data sources, such as genetic data or behavioral metrics, to further personalize treatment. The system could also be adapted for use in other therapeutic areas, such as pain management or neurological disorders.

Potential Commercial Applications and Market

The personalized neuromodulation system has significant commercial potential in the mental health treatment market, with potential applications in treating depression, anxiety, and other mental conditions. The system could also be marketed to hospitals, clinics, and research institutions, providing a competitive advantage in terms of treatment outcomes and patient satisfaction.

CPC Classifications

SectionClassGroup
A A61 A61B34/20
A A61 A61B5/0036
A A61 A61B5/055
A A61 A61N1/20
A A61 A61N1/36096
A A61 A61N2/006
G G01 G01R33/4806
G G01 G01R33/5608

Field of Art

Neurological medical technologies, specifically neuromodulation systems involving brain imaging, stimulation targeting, and personalized therapeutic interventions for mental health conditions

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or neurotechnology researcher with expertise in brain imaging techniques, machine learning algorithms, medical device design, and neurological treatment protocols, holding advanced degrees in bioengineering, neuroscience, or related interdisciplinary fields

Obviousness Rationale

A PHOSITA would recognize that the PTD's machine learning-driven personalization of neuromodulation represents a predictable technological evolution of the source patent's targeted brain stimulation framework. The disclosed adaptive stimulation and 3D brain modeling techniques are logical extensions of existing neuromodulation methodologies, utilizing well-established machine learning approaches to refine treatment precision. The incremental improvements in patient-specific targeting and real-time response adjustment would be considered an obvious optimization within the existing technological landscape.

Obvious Combinations & Variations

Source Patent Element
Targeted brain stimulation system using structural MRI scans
PTD Variation
Adding machine learning algorithms to dynamically identify optimal stimulation targets
Obviousness Reasoning
Applying machine learning to medical imaging is a known technique for improving diagnostic and therapeutic precision, representing a predictable technological progression
Source Patent Element
Brain stimulation for treating mental conditions like major depressive disorder
PTD Variation
Real-time stimulation intensity adjustment based on patient brain activity
Obviousness Reasoning
Adaptive medical interventions are a standard approach in personalized medicine, with feedback mechanisms being a well-established design strategy
Source Patent Element
Transcranial magnetic stimulation targeting specific brain regions
PTD Variation
Generating 3D brain models to identify patient-specific stimulation targets
Obviousness Reasoning
Advanced visualization techniques are a natural evolution in medical imaging, with 3D modeling representing an obvious enhancement to existing 2D targeting methods
Source Patent Element
Brain data processing for neuromodulation
PTD Variation
Incorporating multiple data sources including stimulation response history
Obviousness Reasoning
Expanding data inputs to improve medical treatment precision is a standard approach in personalized medical technologies
Source Patent Element
Basic neuromodulation system with processor and memory
PTD Variation
Deep learning neural network for complex pattern recognition in brain activity
Obviousness Reasoning
Applying advanced machine learning techniques to medical data processing represents a predictable technological advancement within the field
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857275 and the disclosed technological variations, a person having ordinary skill in the art would find the claimed neuromodulation system innovations obvious and non-patentable. The incremental improvements in personalized stimulation targeting, machine learning integration, and adaptive treatment protocols represent predictable extensions of existing neuromodulation technologies, lacking the requisite non-obviousness for patent protection under 35 U.S.C. ยง 103.

Original Patent Information

Patent NumberUS 11,857,275
TitleSystems and methods for targeted neuromodulation
Assignee(s)The Board of Trustees of the Leland Stanford Junior University