Published Technical Disclosure Archive

Personalized Neuromodulation Systems with AI, IoT, Blockchain, and Novel Materials

Publication ID: 24-11857275_0008_PTD
Published: November 07, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Personalized Neuromodulation Systems with AI, IoT, Blockchain, and Novel Materials,” Published Technical Disclosure No. 24-11857275_0008_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11857275_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,275.

Summary of the Inventive Concept

This inventive concept integrates cutting-edge technologies to create a novel, personalized neuromodulation system, enhancing treatment outcomes for patients with various mental health conditions.

Background and Problem Solved

The original patent disclosed a targeted neuromodulation system, but it lacked the power of synergistic combinations with other technologies. This new inventive concept addresses the limitations of the original patent by incorporating AI, IoT, blockchain, and novel materials to create a more effective and secure system.

Detailed Description of the Inventive Concept

The system comprises a wearable brain-computer interface (BCI) device, a cloud-based AI engine, and a blockchain-based secure data storage system. The AI engine analyzes brain activity data from the BCI device and generates a personalized stimulation target, which is securely stored and shared with authorized healthcare providers via the blockchain-based system. Additionally, the system may include an IoT-enabled TMS device and a real-time brain activity monitoring system, enabling real-time optimization of therapy outcomes. Furthermore, the use of novel materials, such as graphene-based electrodes, enhances signal quality and accuracy of stimulation target generation.

Novelty and Inventive Step

The new claims introduce the integration of AI, IoT, blockchain, and novel materials with the original targeted neuromodulation system, providing a synergistic combination that enhances the system's effectiveness, security, and personalization capabilities.

Alternative Embodiments and Variations

Alternative embodiments may include the use of different AI algorithms, varying blockchain architectures, or incorporating other novel materials. Variations may also include adapting the system for different mental health conditions or integrating with other medical devices.

Potential Commercial Applications and Market

This inventive concept has significant commercial potential in the neuromodulation therapy market, particularly in the treatment of mental health conditions such as major depressive disorder. The integration of AI, IoT, blockchain, and novel materials provides a competitive advantage in terms of effectiveness, security, and personalization, making it an attractive solution for healthcare providers and patients.

CPC Classifications

SectionClassGroup
A A61 A61B34/20
A A61 A61B5/0036
A A61 A61B5/055
A A61 A61N1/20
A A61 A61N1/36096
A A61 A61N2/006
G G01 G01R33/4806
G G01 G01R33/5608

Field of Art

Neuromodulation and brain stimulation technologies, encompassing medical imaging, neurological treatment systems, and advanced computational methods for analyzing brain activity and generating personalized therapeutic interventions

Person of Ordinary Skill (PHOSITA) Profile

A skilled practitioner with expertise in neuroscience, biomedical engineering, machine learning, and medical device design, possessing knowledge of brain imaging techniques, AI-driven medical technologies, and personalized treatment methodologies

Obviousness Rationale

A person having ordinary skill in the art would recognize that integrating AI, IoT, blockchain, and advanced materials into the existing neuromodulation framework represents a predictable application of known technologies to enhance personalized brain stimulation therapies. The PTD's variations systematically address limitations in the source patent by introducing computational intelligence, secure data management, and improved signal acquisition techniques. These extensions represent logical technological progressions that would be apparent to a skilled practitioner seeking to optimize neurological treatment systems.

Obvious Combinations & Variations

Source Patent Element
Targeted neuromodulation system using patient brain data and structural MRI scans
PTD Variation
Adding AI-driven analysis and machine learning algorithms to generate personalized stimulation targets
Obviousness Reasoning
Applying machine learning to medical imaging data is a known technique for enhancing diagnostic and treatment precision, representing a predictable technological improvement
Source Patent Element
Brain stimulation therapies targeting specific brain regions
PTD Variation
Incorporating IoT-enabled real-time monitoring and adaptive stimulation parameter adjustment
Obviousness Reasoning
Implementing closed-loop feedback systems for medical devices is a standard approach to optimizing therapeutic interventions, with well-established technological precedents
Source Patent Element
Neuromodulation system processing patient brain data
PTD Variation
Utilizing blockchain for secure data storage and sharing of stimulation targets
Obviousness Reasoning
Applying blockchain technology to medical data management represents a known solution for addressing privacy and security concerns in digital healthcare systems
Source Patent Element
Transcranial magnetic stimulation (TMS) for treating mental health conditions
PTD Variation
Using graphene-based electrodes to enhance signal quality and stimulation accuracy
Obviousness Reasoning
Exploring advanced materials to improve medical device performance is a standard engineering approach with predictable motivations for signal enhancement
Source Patent Element
Brain stimulation targeting specific neurological conditions
PTD Variation
Expanding treatment applications through AI-driven personalization and multi-modal data integration
Obviousness Reasoning
Extending treatment methodologies through computational intelligence represents a logical progression in personalized medical technologies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857275 and the disclosed technological variations, a person having ordinary skill in the art would find the claimed innovations obvious and lacking inventive step. The systematic integration of AI, IoT, blockchain, and novel materials into existing neuromodulation frameworks represents a predictable technological evolution that would be apparent to a skilled practitioner seeking to enhance personalized brain stimulation therapies.

Original Patent Information

Patent NumberUS 11,857,275
TitleSystems and methods for targeted neuromodulation
Assignee(s)The Board of Trustees of the Leland Stanford Junior University