Enhanced Systems and Methods for Optimizing Functional Images of a Lesion Region using Guided Diffuse Optical Tomography

Publication ID: 24-11857289_0001_PTD
Published: November 07, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Enhanced Systems and Methods for Optimizing Functional Images of a Lesion Region using Guided Diffuse Optical Tomography,” Published Technical Disclosure No. 24-11857289_0001_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11857289_0001_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,289.

Summary of the Inventive Concept

This inventive concept improves upon existing guided diffuse optical tomography (DOT) systems by integrating machine learning, artificial intelligence, deep learning, and computer vision modules to enhance image quality, reduce noise, and optimize functional images of a lesion region.

Background and Problem Solved

The original patent, 'Systems and methods of optimizing functional images of a lesion region using guided diffuse optical tomography,' has limitations in image quality and noise reduction. This new inventive concept addresses these limitations by leveraging advanced computational techniques to improve the accuracy and efficiency of DOT systems.

Detailed Description of the Inventive Concept

The enhanced system comprises a DOT device integrated with a machine learning module, an artificial intelligence module, a deep learning module, or a computer vision module. These advanced computational modules are trained using datasets of images from multiple subjects to improve image quality and reduce noise. The system acquires lesion functional data from the lesion region and reference functional data from a healthy tissue region, applying the advanced computational techniques to generate optimized functional images. This integration enables the system to better distinguish between healthy and diseased tissues, leading to more accurate diagnoses and treatments.

Novelty and Inventive Step

The novelty of this inventive concept lies in the integration of advanced computational modules with DOT devices to improve image quality and reduce noise. This integration is non-obvious and provides a significant improvement over the original patent, enabling more accurate and efficient diagnoses.

Alternative Embodiments and Variations

Alternative embodiments of this inventive concept could include integrating different types of machine learning algorithms, using various deep learning architectures, or incorporating computer vision techniques for image segmentation. Additionally, the system could be adapted for use in other medical imaging applications, such as imaging other types of cancer or diseases.

Potential Commercial Applications and Market

This enhanced system has significant commercial potential in the medical imaging industry, particularly in the diagnosis and treatment of breast cancer. The improved image quality and reduced noise enable more accurate diagnoses, leading to better patient outcomes and reduced healthcare costs. The system could be marketed to hospitals, clinics, and research institutions, and could also be used in other medical imaging applications.

Field of Art

Medical imaging, specifically diffuse optical tomography (DOT) for breast cancer diagnostics, requiring expertise in optical imaging, signal processing, computational methods, and medical image analysis

Person of Ordinary Skill (PHOSITA) Profile

A skilled practitioner with advanced degrees in biomedical engineering, medical physics, or computational imaging, possessing knowledge of medical imaging techniques, machine learning, signal processing algorithms, and image optimization strategies

Obviousness Rationale

A person having ordinary skill in the art would recognize that integrating machine learning and computational modules with existing DOT systems represents a predictable and logical extension of the source patent's imaging optimization techniques. The PTD's proposed computational enhancements directly address known challenges in medical image quality and noise reduction using standard machine learning approaches. These variations would be considered obvious improvements that leverage well-established computational techniques to enhance the original DOT imaging methodology.

Obvious Combinations & Variations

Source Patent Element
DOT device for acquiring lesion and reference functional data with voxel-based imaging
PTD Variation
Integrating machine learning modules to improve image quality and reduce noise during data acquisition
Obviousness Reasoning
Applying machine learning to image processing is a known technique in medical imaging, representing a predictable solution to enhance signal-to-noise ratios and image resolution
Source Patent Element
Functional image optimization using matrix processing techniques
PTD Variation
Implementing deep learning and artificial intelligence modules for advanced image optimization
Obviousness Reasoning
Computational image enhancement through AI techniques is a standard approach in medical imaging, offering incremental improvements using well-understood algorithmic strategies
Source Patent Element
Functional imaging of lesion regions with reference tissue comparisons
PTD Variation
Training computational modules using multi-subject image datasets to improve diagnostic accuracy
Obviousness Reasoning
Using training datasets to improve computational medical imaging techniques is a standard practice in machine learning and represents an obvious extension of existing imaging methodologies
Source Patent Element
Voxel-based imaging with fine and coarse resolution regions
PTD Variation
Incorporating computer vision modules for advanced image segmentation and tissue differentiation
Obviousness Reasoning
Computer vision techniques for medical image segmentation are well-established, representing a predictable technological improvement for distinguishing tissue characteristics
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857289 and the published technical disclosure, a person having ordinary skill in the art would find the proposed variations in computational medical imaging techniques to be obvious and non-inventive. The integration of machine learning, artificial intelligence, deep learning, and computer vision modules with existing diffuse optical tomography systems represents a predictable technological evolution that would be apparent to a skilled practitioner in the field of medical imaging and computational diagnostics.

Original Patent Information

Patent NumberUS 11,857,289
TitleSystems and methods of optimizing functional images of a lesion region using guided diffuse optical tomography
Assignee(s)Washington University