Guided Diffuse Optical Tomography for Novel Applications

Publication ID: 24-11857289_0002_PTD
Published: November 07, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Guided Diffuse Optical Tomography for Novel Applications,” Published Technical Disclosure No. 24-11857289_0002_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11857289_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,289.

Summary of the Inventive Concept

This inventive concept extends the core technology of guided diffuse optical tomography (DOT) to novel applications beyond breast cancer imaging, including crop health monitoring, water contaminant detection, soil composition analysis, industrial process monitoring, and food quality inspection.

Background and Problem Solved

The original patent focused on optimizing functional images of a lesion region using guided DOT. However, this technology has broader potential. The new inventive concept addresses the limitation of the original patent by exploring its application to entirely different industries, including agriculture, environmental monitoring, industrial process control, and food safety.

Detailed Description of the Inventive Concept

The inventive concept involves adapting the guided DOT technology to various new applications. For instance, in crop health monitoring, the DOT device acquires crop functional data and generates optimized functional images of the crop region, enabling early detection of crop stress or disease. Similarly, in water contaminant detection, the DOT device acquires contaminant functional data and generates optimized functional images of the water sample, allowing for rapid identification of contaminants. The inventive concept also encompasses adaptations for soil composition analysis, industrial process monitoring, and food quality inspection, each leveraging the core DOT technology to address specific challenges in their respective fields.

Novelty and Inventive Step

The new claims introduce novel applications of guided DOT, expanding its scope beyond breast cancer imaging. The inventive step lies in recognizing the potential of guided DOT to address diverse problems in various industries, and adapting the technology to meet the specific needs of each application.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different DOT device configurations, modified data acquisition protocols, or integration with other sensing modalities to enhance the accuracy and versatility of the technology. Variations could also involve adapting the guided DOT technology for use in other industries, such as pharmaceuticals or biomedical research.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential, with applications in agriculture, environmental monitoring, industrial process control, and food safety. The market for guided DOT technology in these industries is substantial, driven by the need for efficient, accurate, and non-invasive monitoring and inspection tools.

Field of Art

Optical imaging systems, specifically diffuse optical tomography (DOT) with applications in medical diagnostics, agricultural monitoring, and industrial sensing

Person of Ordinary Skill (PHOSITA) Profile

A skilled practitioner with expertise in optical imaging, signal processing, data analysis, and interdisciplinary sensor technology, holding advanced degrees in engineering, physics, or biomedical sciences with experience in adapting imaging technologies across domains

Obviousness Rationale

A person of ordinary skill would recognize the fundamental DOT technology disclosed in the source patent as a versatile imaging methodology capable of adaptation across multiple technical domains. The core principles of acquiring functional data, generating optimized images using matrix processing techniques, and extracting meaningful spatial information are directly transferable between different application contexts. The PTD demonstrates predictable extensions of the source patent's core technological framework by applying identical DOT methodological principles to alternative domains with substantially similar data acquisition and image generation requirements.

Obvious Combinations & Variations

Source Patent Element
DOT device configured to acquire lesion functional data with fine and coarse voxel sizes
PTD Variation
Acquiring crop, water, soil, industrial process, and food functional data using equivalent DOT imaging principles
Obviousness Reasoning
Known technique of adapting sensor technology across domains with predictable results, representing a straightforward design choice for a skilled practitioner
Source Patent Element
Generating optimized functional images using truncated pseudoinverse matrix processing
PTD Variation
Applying identical matrix processing techniques to generate functional images in non-medical domains
Obviousness Reasoning
Mathematical signal processing methods are universally applicable when underlying data structures and acquisition protocols remain consistent
Source Patent Element
Newton method for image optimization in medical DOT imaging
PTD Variation
Extending Newton method optimization to functional image generation in agricultural, industrial, and environmental monitoring contexts
Obviousness Reasoning
Computational optimization techniques are domain-independent when fundamental mathematical principles remain unchanged
Source Patent Element
Comparative functional data acquisition between lesion and healthy tissue regions
PTD Variation
Acquiring comparative functional data in crop health, water quality, and industrial process monitoring scenarios
Obviousness Reasoning
Comparative imaging technique represents a generalizable approach to detecting anomalies across different technical domains
Source Patent Element
Guided DOT system for acquiring spatially resolved functional data
PTD Variation
Implementing guided DOT principles for spatially resolved functional imaging in non-medical applications
Obviousness Reasoning
Spatial data acquisition methodology represents a transferable technical approach with predictable implementation across diverse sensing contexts
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857289, a person having ordinary skill in the art would find the variations disclosed in the Published Technical Disclosure to represent obvious extensions of the source patent's core diffuse optical tomography technology. The claimed variations constitute predictable applications of known imaging methodologies, employing substantially identical technical approaches across multiple domains, and therefore would be considered obvious to a skilled practitioner at the time of invention.

Original Patent Information

Patent NumberUS 11,857,289
TitleSystems and methods of optimizing functional images of a lesion region using guided diffuse optical tomography
Assignee(s)Washington University