Enhanced Systems and Methods for Optimizing Functional Images of a Lesion Region using Guided Diffuse Optical Tomography

Publication ID: 24-11857289_0006_PTD
Published: November 07, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Enhanced Systems and Methods for Optimizing Functional Images of a Lesion Region using Guided Diffuse Optical Tomography,” Published Technical Disclosure No. 24-11857289_0006_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11857289_0006_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,289.

Summary of the Inventive Concept

An improved system and method for generating optimized functional images of a lesion region using guided diffuse optical tomography, enhancing image quality, speed, and accuracy through adaptive intensity adjustment, machine learning, sparse coding, wavelet transform, and deep learning algorithms.

Background and Problem Solved

The original patent, 'Systems and methods of optimizing functional images of a lesion region using guided diffuse optical tomography', addresses the limitations of breast cancer imaging using diffuse optical tomography (DOT). However, the original patent has inherent limitations, such as fixed optical signal intensity, limited image processing capabilities, and lack of adaptability. The new inventive concept addresses these limitations by introducing adaptive intensity adjustment, advanced image processing algorithms, and improved computational efficiency.

Detailed Description of the Inventive Concept

The enhanced system comprises a DOT device configured to acquire lesion functional data from the lesion region and reference functional data from a healthy tissue region. The DOT device is adapted to adjust the intensity of the optical signal based on the distance between the lesion region and the healthy tissue region. The system also includes a processing unit configured to process the lesion functional data and the reference functional data using machine learning, sparse coding, wavelet transform, or deep learning algorithms to generate optimized functional images. The new claims provide improved image quality, speed, and accuracy, enabling better diagnosis and treatment of breast cancer.

Novelty and Inventive Step

The new inventive concept's novelty lies in the adaptive intensity adjustment, advanced image processing algorithms, and improved computational efficiency, which are not present in the original patent. The inventive step is the combination of these features, which provides a significant improvement over the existing technology.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept include using different machine learning algorithms, sparse coding techniques, wavelet transform methods, or deep learning architectures. Variations of the system could include using different DOT devices, processing units, or image reconstruction algorithms to generate optimized functional images.

Potential Commercial Applications and Market

The enhanced system and method have significant commercial potential in the medical imaging industry, particularly in breast cancer diagnosis and treatment. The target market includes hospitals, clinics, and research institutions, with potential for expansion into other medical imaging applications.

Field of Art

Medical imaging, specifically diffuse optical tomography (DOT) for breast cancer diagnostics, requiring expertise in optical signal processing, image reconstruction algorithms, and medical imaging techniques

Person of Ordinary Skill (PHOSITA) Profile

A skilled practitioner with advanced degrees in biomedical engineering, medical physics, or related fields, possessing knowledge of medical imaging technologies, signal processing, machine learning, and computational image reconstruction methods

Obviousness Rationale

A person having ordinary skill in the art would recognize that the published technical disclosure represents predictable variations of the source patent's core DOT imaging methodology. The proposed enhancements of adaptive signal intensity adjustment and advanced computational processing techniques are logical extensions of the existing DOT imaging framework. These modifications represent standard engineering approaches to improving medical imaging resolution and diagnostic accuracy.

Obvious Combinations & Variations

Source Patent Element
DOT device acquiring lesion and reference functional data with voxel-based imaging
PTD Variation
Adding adaptive optical signal intensity adjustment based on lesion-healthy tissue distance
Obviousness Reasoning
A PHOSITA would recognize signal intensity calibration as a routine optimization technique in medical imaging, with predictable improvements in image quality and diagnostic precision
Source Patent Element
Image reconstruction using matrix-based processing methods
PTD Variation
Incorporating machine learning, sparse coding, and deep learning algorithms for image generation
Obviousness Reasoning
Advanced computational techniques are well-known in medical imaging for enhancing signal processing and reconstruction, representing a predictable application of emerging computational methods
Source Patent Element
Functional imaging of lesion regions using DOT technology
PTD Variation
Implementing wavelet transform and alternative signal processing techniques
Obviousness Reasoning
Signal processing method selection is a design choice within a finite set of known techniques, obvious to a skilled practitioner seeking improved image reconstruction
Source Patent Element
Pseudoinverse matrix-based image reconstruction
PTD Variation
Applying alternative computational approaches like sparse coding and deep learning
Obviousness Reasoning
Computational image reconstruction methods are interchangeable for a PHOSITA, with selection driven by performance characteristics and computational efficiency
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857289 and the published technical disclosure, a person having ordinary skill in the art would find the claimed variations obvious and anticipated, as the proposed enhancements represent predictable extensions of existing diffuse optical tomography imaging methodologies through routine engineering modifications and well-known computational techniques.

Original Patent Information

Patent NumberUS 11,857,289
TitleSystems and methods of optimizing functional images of a lesion region using guided diffuse optical tomography
Assignee(s)Washington University