Intelligent Cardiovascular Disease Diagnosis and Monitoring System

Publication ID: 24-11857318_0003_PTD
Published: November 07, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Intelligent Cardiovascular Disease Diagnosis and Monitoring System,” Published Technical Disclosure No. 24-11857318_0003_PTD, Published November 07, 2025, available at https://archive.pr1or.art/24-11857318_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,318.

Summary of the Inventive Concept

A novel system integrating electrochemical impedance spectroscopy with AI, IoT, blockchain, and nanomaterials for accurate cardiovascular disease diagnosis, monitoring, and personalized health recommendations.

Background and Problem Solved

The original patent addressed the limitations of conventional plaque rupture detection methods, but it lacked the integration of advanced technologies to enhance its capabilities. The new inventive concept overcomes this limitation by combining electrochemical impedance spectroscopy with AI, IoT, blockchain, and nanomaterials to provide a comprehensive and accurate cardiovascular disease diagnosis and monitoring system.

Detailed Description of the Inventive Concept

The system comprises a tissue sensing device (as described in the original patent) that collects electrical impedance spectroscopy data, which is then transmitted to a cloud-based IoT platform for analysis using artificial intelligence algorithms. The system also incorporates a machine learning module trained on a dataset of plaque rupture events, a blockchain-based data storage system for securely storing and sharing patient data, and a nanomaterial-based contrast agent for enhancing ultrasound imaging. The system's components work synergistically to identify high-risk atherosclerotic lesions, detect metabolically active lesions, and provide personalized health recommendations.

Novelty and Inventive Step

The new inventive concept's novelty lies in the integration of electrochemical impedance spectroscopy with AI, IoT, blockchain, and nanomaterials, which enables accurate cardiovascular disease diagnosis, monitoring, and personalized health recommendations. The inventive step is the synergistic combination of these distinct technologies to create a more powerful system.

Alternative Embodiments and Variations

Alternative embodiments may include using different types of sensors or imaging modalities, integrating with other healthcare systems or wearables, or applying the system to other disease diagnosis and monitoring applications.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the healthcare industry, particularly in the areas of cardiovascular disease diagnosis and monitoring. The system's ability to provide accurate and personalized health recommendations can lead to improved patient outcomes, reduced healthcare costs, and increased market share for companies adopting this technology.

Field of Art

Biomedical engineering, medical diagnostics, specifically cardiovascular imaging and sensing technologies with expertise in electrochemical impedance spectroscopy, ultrasound imaging, and advanced data analysis techniques

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device researcher with advanced degrees, proficient in medical sensor design, signal processing, machine learning, and interdisciplinary technology integration, familiar with emerging diagnostic technologies and computational healthcare solutions

Obviousness Rationale

A PHOSITA would recognize that the PTD represents a predictable combination of known medical diagnostic technologies, extending the source patent's tissue sensing device through standard engineering techniques of integrating machine learning, IoT platforms, and advanced data analysis methods. The core tissue sensing mechanism remains fundamentally unchanged, with added computational and data management layers that represent incremental technological improvements. The proposed variations demonstrate standard technological evolution by applying known computational techniques to an existing medical sensing framework.

Obvious Combinations & Variations

Source Patent Element
Tissue sensing device with ultrasound transducer and catheter configuration
PTD Variation
Adding machine learning analysis and IoT data transmission capabilities
Obviousness Reasoning
Integrating computational analysis with medical sensing devices is a known technique, representing a predictable application of machine learning to diagnostic technologies
Source Patent Element
Electrical impedance spectroscopy measurement technique
PTD Variation
Blockchain-based secure data storage and sharing mechanism
Obviousness Reasoning
Implementing secure data management for medical diagnostics is a standard design choice in healthcare technology, representing an obvious extension of existing data handling practices
Source Patent Element
Tissue sensing device for cardiovascular diagnostics
PTD Variation
Nanomaterial-based contrast agent for enhanced ultrasound imaging
Obviousness Reasoning
Using advanced contrast agents to improve medical imaging resolution is a well-established technique in biomedical engineering, representing a predictable technological improvement
Source Patent Element
Catheter-based tissue sensing mechanism
PTD Variation
Cloud-based IoT platform for real-time data analysis and health monitoring
Obviousness Reasoning
Transitioning medical diagnostic data to cloud platforms is a standard technological progression, representing an obvious implementation of contemporary digital health infrastructure
Source Patent Element
Electrical impedance spectroscopy for tissue characterization
PTD Variation
Genomics-based analysis module for identifying cardiovascular disease markers
Obviousness Reasoning
Combining multiple diagnostic modalities is a standard approach in personalized medicine, representing a predictable technological integration strategy
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857318 and the disclosed technological variations, a person having ordinary skill in the art would find the proposed system and method variations obvious and lacking inventive step. The incremental technological improvements represent standard engineering practices of integrating computational, data management, and diagnostic technologies, thereby rendering potential patent claims obvious and anticipated by the existing prior art.

Original Patent Information

Patent NumberUS 11,857,318
TitleElectrochemical impedance spectroscopy
Assignee(s)The Regents of the University of California