Synergistic Electrochemical Impedance Spectroscopy System
Legal Citation
Summary of the Inventive Concept
A novel system integrating electrochemical impedance spectroscopy (EIS) with artificial intelligence (AI), blockchain, IoT, and nanomaterials to predict plaque rupture, identify metabolically active atherosclerotic lesions, and enable personalized treatment of atherosclerosis.
Background and Problem Solved
The original patent disclosed an electrochemical impedance spectroscopy device for characterizing regions of tissue. However, it had limitations in terms of data analysis, security, and real-time feedback. The new inventive concept addresses these limitations by synergistically combining EIS with AI, blockchain, IoT, and nanomaterials to create a more powerful system for predicting plaque rupture and identifying metabolically active atherosclerotic lesions.
Detailed Description of the Inventive Concept
The new system comprises a tissue sensing device with EIS sensors, an AI module for analyzing EIS data and identifying patterns indicative of plaque rupture, a cloud-based storage system for storing and processing EIS data and AI analysis results, an IoT-enabled communication module for transmitting EIS data to a remote server, a server-side analytics platform for analyzing EIS data and providing real-time feedback to a healthcare provider, a nanomaterial-based sensor for detecting biomarkers of plaque rupture, and a microcontroller for integrating EIS data and biomarker detection results. The system can be used to predict plaque rupture, identify metabolically active atherosclerotic lesions, and enable personalized treatment of atherosclerosis.
Novelty and Inventive Step
The new claims introduce a synergistic combination of EIS with AI, blockchain, IoT, and nanomaterials, which is novel and non-obvious compared to the original patent. The integration of these distinct technologies enables a more powerful system for predicting plaque rupture and identifying metabolically active atherosclerotic lesions.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include using different types of sensors, such as optical or acoustic sensors, or integrating the system with other medical imaging modalities, such as MRI or CT scans. Variations of the system could also include using different AI algorithms or blockchain networks.
Potential Commercial Applications and Market
The synergistic electrochemical impedance spectroscopy system has significant commercial potential in the medical device industry, particularly in the areas of cardiovascular disease diagnosis and treatment. The system could be marketed to hospitals, clinics, and research institutions, and could potentially disrupt the current market for cardiovascular disease diagnosis and treatment.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Biomedical engineering, medical device design, and diagnostic systems with a focus on cardiovascular tissue sensing and analysis technologies
Person of Ordinary Skill (PHOSITA) Profile
A biomedical engineer or medical device researcher with expertise in catheter-based sensing technologies, electrochemical impedance spectroscopy, and advanced data analysis techniques, holding advanced degrees in bioengineering or medical technology
Obviousness Rationale
A person of ordinary skill would recognize that integrating AI, IoT, and advanced data processing with existing tissue sensing technologies represents a predictable extension of the source patent's core methodology. The fundamental tissue sensing approach remains consistent, with the PTD merely adding contemporary computational and communication technologies to enhance diagnostic capabilities. These technological additions represent well-known approaches to improving medical diagnostic systems through data integration and intelligent analysis.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,318 |
|---|---|
| Title | Electrochemical impedance spectroscopy |
| Assignee(s) | The Regents of the University of California |