Next-Generation Electrochemical Impedance Spectroscopy for Cardiovascular Event Prediction

A bioelectronic system leveraging electrochemical impedance spectroscopy (EIS) for predicting cardiovascular events, enabling early intervention and personalized treatment.

The original patent disclosed an electrochemical impedance spectroscopy device for detecting atherosclerotic lesions. However, it had limitations in predicting cardiovascular events. The new inventive concept addresses this limitation by integrating EIS with advanced analytics, imaging modalities, and wearable devices to provide a more comprehensive and proactive approach to cardiovascular health monitoring.

The next-generation EIS system comprises implantable devices, wearable sensors, and computer-aided diagnosis tools. These components work together to measure EIS signals, detect high-risk plaques, and provide personalized treatment recommendations. The system can be further augmented with hybrid imaging modalities, such as photoacoustic imaging, to visualize lesions in real-time. Additionally, nanotechnology-based EIS sensors can be used for in vivo detection of biomarkers associated with atherosclerosis, enabling early warning of cardiovascular events.

The new claims introduce a paradigm shift in cardiovascular health monitoring by integrating EIS with advanced analytics, imaging modalities, and wearable devices. This integration enables the prediction of cardiovascular events, which is a significant departure from the original patent's focus on lesion detection.

Alternative embodiments may include using different types of sensors, such as optical or acoustic sensors, to measure EIS signals. Additionally, the system could be adapted for use in other medical applications, such as cancer diagnosis or neurological disorder monitoring.

The next-generation EIS system has significant commercial potential in the cardiovascular health monitoring market, which is projected to grow substantially in the coming years. The system's ability to predict cardiovascular events and provide personalized treatment recommendations makes it an attractive solution for healthcare providers, patients, and payers.