Published Technical Disclosure Archive

Enhanced Microneedle Fabrication and Implantation System

Publication ID: 24-11857343_0001_PTD
Published: October 28, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Enhanced Microneedle Fabrication and Implantation System,” Published Technical Disclosure No. 24-11857343_0001_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857343_0001_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,343.

Summary of the Inventive Concept

An improved microneedle fabrication and implantation system for precise and efficient implantation of devices into biological tissues, addressing limitations of existing microneedle designs.

Background and Problem Solved

The original patent for microneedle fabrication and device implantation has limitations in terms of precision, safety, and efficiency. The new inventive concept addresses these limitations by introducing temperature control mechanisms, ablating outer membranes, and applying nano-coatings to enhance biocompatibility.

Detailed Description of the Inventive Concept

The new system comprises a microneedle fabricated using the methods of claim 1, with additional features such as temperature control mechanisms to regulate the temperature of the biological tissue during implantation. The system also includes a method for inserting an implantable device into a biological tissue, involving ablating a section of the outer membrane using a laser and inserting the implantable device through the ablated section using a microneedle. Furthermore, the microneedle is designed with a primary helix and a secondary helix, where the primary helix is brazed with a braze material and the secondary helix is coated with a bio-compatible material. The fabrication method involves applying a nano-coating to the primary helix to enhance its biocompatibility.

Novelty and Inventive Step

The new claims introduce novel features such as temperature control mechanisms, ablating outer membranes, and applying nano-coatings, which are not present in the original patent. These features provide a significant improvement in precision, safety, and efficiency of the microneedle fabrication and implantation system.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include using different materials for the microneedle, varying the design of the primary and secondary helices, or incorporating additional features such as sensors or actuators to enhance the implantation process.

Potential Commercial Applications and Market

The enhanced microneedle fabrication and implantation system has potential commercial applications in the fields of neurosurgery, ophthalmology, and dermatology, with a target market including medical device manufacturers, research institutions, and hospitals.

CPC Classifications

SectionClassGroup
A A61 A61B5/685
A A61 A61B5/1459
A A61 A61B5/1473
A A61 A61B5/6868
A A61 A61K41/0028
A A61 A61N1/0502
A A61 A61N1/0529
A A61 A61N1/0551
A A61 A61N5/0601
B B21 B21F45/008
A A61 A61B2562/12
A A61 A61N2005/0612
A A61 A61N2005/0651
B B23 B23K1/0008
B B23 B23K2101/32

Field of Art

Biomedical engineering and microsurgical device fabrication, focusing on microneedle design, neurosurgical targeting techniques, and implantable medical devices with expertise in wire fabrication, surface coating, and minimally invasive surgical technologies

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device designer with advanced degrees in bioengineering, materials science, or related fields, possessing expertise in microfabrication techniques, understanding of wire processing, brazing methods, and knowledge of biocompatible surface modifications

Obviousness Rationale

A person having ordinary skill in the art would recognize that the PTD's variations represent predictable extensions of the source patent's microneedle fabrication method. The additional features such as temperature control, membrane ablation, and nano-coating are logical engineering improvements that would be apparent to a skilled practitioner seeking to optimize microneedle performance and biocompatibility. These modifications represent standard design iterations within the established technological framework of microneedle device development.

Obvious Combinations & Variations

Source Patent Element
Microneedle fabrication method using wire winding and brazing
PTD Variation
Adding temperature control mechanism during tissue implantation
Obviousness Reasoning
Controlling thermal conditions during medical device insertion is a known technique for minimizing tissue damage, representing a predictable solution for improving surgical precision
Source Patent Element
Primary helix wire structure
PTD Variation
Applying nano-coating to enhance biocompatibility
Obviousness Reasoning
Surface modification of medical devices using nano-coatings is a well-established method for improving tissue interaction and reducing immune response, constituting a routine engineering optimization
Source Patent Element
Microneedle with reversible engagement feature
PTD Variation
Incorporating feedback mechanism to adjust engagement in real-time
Obviousness Reasoning
Adding real-time monitoring and adaptive control represents a standard approach to improving medical device performance, utilizing known sensor and control technologies
Source Patent Element
Wire-based microneedle fabrication
PTD Variation
Using laser ablation to create tissue entry point
Obviousness Reasoning
Laser-assisted tissue penetration is a known technique in microsurgical procedures, representing a predictable method for improving device insertion precision
Source Patent Element
Single helix microneedle design
PTD Variation
Introducing secondary helix with bio-compatible coating
Obviousness Reasoning
Multilayer device design with specialized surface treatments is a common approach to enhancing medical device functionality, representing an obvious design variation
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857343 and the disclosed technical variations, a person having ordinary skill in the art would find the claimed microneedle fabrication and implantation techniques obvious and anticipated. The incremental improvements in device design, surface modification, and insertion methodology represent predictable engineering solutions within the established technological domain of microneedle device development, thereby rendering subsequent claims obvious under 35 U.S.C. Section 103.

Original Patent Information

Patent NumberUS 11,857,343
TitleMicroneedle fabrication and device implantation
Assignee(s)The Regents of the University of California