Next-Generation Synthetic Breast Tissue Image Generation System

Publication ID: 24-11857358_0010_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Next-Generation Synthetic Breast Tissue Image Generation System,” Published Technical Disclosure No. 24-11857358_0010_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857358_0010_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,358.

Summary of the Inventive Concept

A novel system and method for generating synthetic breast tissue images with enhanced tissue visibility, utilizing advanced machine learning and physics-based models to overcome limitations of traditional high-density element suppression techniques.

Background and Problem Solved

Traditional breast imaging techniques, such as tomosynthesis, often struggle with obtrusive high-density elements, which can obscure critical tissue structures. The original patent addressed this issue through high-density element suppression, but limitations remain. The new inventive concept addresses these limitations by introducing advanced machine learning and physics-based models to generate synthetic breast tissue images with enhanced tissue visibility.

Detailed Description of the Inventive Concept

The next-generation system comprises a neural network trained on a dataset of high-density element-suppressed images to predict suppressed tissue structures. The system also includes a processing module to generate a synthesized image with enhanced tissue visibility. Alternatively, a generative adversarial network can be trained on paired high-density element-suppressed and corresponding high-density element-enhanced images to generate a synthesized image. The system can also utilize a database of high-density element-suppressed images and a machine learning model to predict suppressed tissue structures. Additionally, a high-density element detection module can identify regions of high-density elements in an input image, and a processing module can apply a physics-based model to simulate the suppression of high-density elements in the identified regions.

Novelty and Inventive Step

The new inventive concept introduces the use of advanced machine learning models, such as neural networks and generative adversarial networks, to predict suppressed tissue structures and generate synthetic breast tissue images with enhanced tissue visibility. This represents a significant departure from traditional high-density element suppression techniques, offering improved image quality and diagnostic accuracy.

Alternative Embodiments and Variations

Alternative embodiments may include the use of other machine learning models, such as deep learning-based image enhancement algorithms, or the integration of additional data sources, such as patient-specific information or multi-modal imaging data. Variations may also include the application of the inventive concept to other medical imaging modalities, such as MRI or CT scans.

Potential Commercial Applications and Market

The next-generation synthetic breast tissue image generation system has significant commercial potential in the medical imaging industry, particularly in the areas of breast cancer screening and diagnosis. The system's ability to generate high-quality images with enhanced tissue visibility can improve diagnostic accuracy and patient outcomes, making it an attractive solution for healthcare providers and medical device manufacturers.

CPC Classifications

SectionClassGroup
A A61 A61B6/5258
A A61 A61B6/461
A A61 A61B6/502
G G06 G06T11/008
G G06 G06T2207/10116
G G06 G06T2207/30068

Field of Art

Medical imaging, specifically breast tissue tomosynthesis and synthetic image generation, involving advanced image processing techniques, machine learning, and radiological image enhancement technologies

Person of Ordinary Skill (PHOSITA) Profile

A skilled practitioner with expertise in medical imaging, computer vision, machine learning, and radiological image processing, typically holding a PhD or equivalent professional experience in biomedical engineering, medical imaging, or computational radiology

Obviousness Rationale

The published technical disclosure represents predictable variations on the source patent's core methodology of synthetic breast tissue image generation by applying well-established machine learning techniques to the existing high-density element suppression framework. A person having ordinary skill would recognize that neural networks and generative adversarial networks are standard approaches for image enhancement and reconstruction tasks in medical imaging. The proposed variations merely substitute traditional image processing algorithms with contemporary machine learning models to achieve substantially similar outcomes of improved tissue visibility.

Obvious Combinations & Variations

Source Patent Element
X-ray image acquisition of multiple 2D projection images at different angles
PTD Variation
Neural network trained on high-density element-suppressed image datasets to predict suppressed tissue structures
Obviousness Reasoning
Applying machine learning to image reconstruction is a known technique in medical imaging, representing a predictable technological evolution with expected improvements in image processing accuracy
Source Patent Element
Image processing methods for high-density element suppression
PTD Variation
Generative adversarial network trained on paired high-density element-suppressed and enhanced images
Obviousness Reasoning
Substituting traditional image processing with advanced neural network architectures is an obvious design choice for a skilled practitioner seeking improved diagnostic image generation
Source Patent Element
Three-dimensional image slice generation based on enhanced breast tissue
PTD Variation
Physics-based model simulation of high-density element suppression using machine learning segmentation
Obviousness Reasoning
Integrating machine learning with existing physics-based models represents a straightforward technological progression with predictable performance improvements
Source Patent Element
Digital mammographic image processing system
PTD Variation
Deep learning-based image enhancement algorithms applied to segmented image regions
Obviousness Reasoning
Region-based enhancement techniques are well-known in image processing, and applying deep learning to such segmentation represents an incremental, obvious technological advancement
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857358 and the published technical disclosure, a person having ordinary skill in medical imaging would find the proposed synthetic breast tissue image generation techniques obvious and lacking inventive merit. The disclosed variations represent predictable applications of contemporary machine learning methodologies to established radiological image processing frameworks, thereby rendering potential patent claims obvious and anticipated by existing prior art.

Original Patent Information

Patent NumberUS 11,857,358
TitleSystem and method for synthetic breast tissue image generation by high density element suppression
Assignee(s)Hologic, Inc.