Advanced Multi-Frequency Harmonic Acoustography System for Enhanced Target Tissue Identification and Border Detection

Publication ID: 24-11857373_0001_PTD
Published: October 28, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Advanced Multi-Frequency Harmonic Acoustography System for Enhanced Target Tissue Identification and Border Detection,” Published Technical Disclosure No. 24-11857373_0001_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857373_0001_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,373.

Summary of the Inventive Concept

This inventive concept presents a novel, high-performance multi-frequency harmonic acoustography system that significantly improves target tissue identification and border detection capabilities. The system integrates advanced technologies, including dynamically adjustable frequency differences, dual-mode transducers, real-time signal processing, adaptive filtering, and compact probe designs, to provide high-contrast images, enhanced target tissue characterization, and improved portability.

Background and Problem Solved

The original patent, 'Multi-frequency harmonic acoustography for target identification and border detection,' introduced a method for performing multi-frequency harmonic acoustography for target tissue identification and border detection within a target tissue. However, the original patent's limitations include fixed frequency differences, limited transducer capabilities, and lack of real-time signal processing. The new inventive concept addresses these limitations by introducing advanced features that significantly enhance the system's performance, usability, and versatility.

Detailed Description of the Inventive Concept

The advanced multi-frequency harmonic acoustography system comprises a focused confocal transducer with a dynamically adjustable frequency difference Δf, allowing for real-time optimization of target tissue identification and border detection. The system also features a dual-mode transducer capable of switching between high-frequency and low-frequency operation, enhancing target tissue characterization. A real-time signal processing module provides instantaneous feedback on target tissue properties during imaging, while an adaptive filtering technique suppresses background noise and enhances target tissue visibility. The system's compact, handheld probe design ensures enhanced portability and ease of use in clinical settings.

Novelty and Inventive Step

The new inventive concept's novelty lies in its integration of advanced features, including dynamically adjustable frequency differences, dual-mode transducers, real-time signal processing, adaptive filtering, and compact probe designs. These features, individually and collectively, provide a significant improvement over the original patent, offering enhanced performance, usability, and versatility.

Alternative Embodiments and Variations

Alternative embodiments of the advanced multi-frequency harmonic acoustography system could include variations in transducer design, such as using phased arrays or annular arrays, or incorporating additional features like Doppler ultrasound or elastography. The system could also be adapted for use in different clinical settings, such as cardiology or neurology, or integrated with other imaging modalities like MRI or CT.

Potential Commercial Applications and Market

The advanced multi-frequency harmonic acoustography system has significant commercial potential in the medical imaging industry, particularly in the fields of oncology, cardiology, and neurology. The system's enhanced performance, usability, and versatility make it an attractive solution for clinicians and researchers seeking to improve patient outcomes and advance medical research.

CPC Classifications

SectionClassGroup
A A61 A61B8/485
A A61 A61B8/085
A A61 A61B8/4494
B B06 B06B1/0622
G G01 G01S7/52038
G G01 G01S15/8913
G G01 G01S15/8922
G G01 G01S15/8952
A A61 A61B8/5207
G G01 G01S7/5203

Field of Art

Medical ultrasound imaging and diagnostic technologies, specifically multi-frequency harmonic acoustography for tissue characterization and border detection, requiring advanced knowledge of ultrasound physics, signal processing, transducer design, and medical imaging techniques

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical imaging specialist with expertise in ultrasound technologies, signal processing algorithms, transducer design, and clinical diagnostic imaging techniques, holding advanced degrees in biomedical engineering, electrical engineering, or medical physics

Obviousness Rationale

A person having ordinary skill in the art would recognize that the PTD's disclosed variations represent predictable extensions of the source patent's core multi-frequency harmonic acoustography methodology. The technical modifications involve standard engineering design choices and incremental improvements that would be apparent to a skilled practitioner familiar with ultrasound imaging technologies. The PTD's enhancements, such as dynamically adjustable frequency differences and adaptive filtering, represent logical refinements to the existing technological framework established in the source patent.

Obvious Combinations & Variations

Source Patent Element
Confocal transducer with piezoelectric elements for generating ultrasonic waves at different frequencies
PTD Variation
Dual-mode transducer capable of switching between high and low frequency operations with dynamically adjustable frequency difference
Obviousness Reasoning
A PHOSITA would recognize that frequency modulation and transducer design are predictable variations within ultrasound imaging technologies, representing a known technique for enhancing diagnostic capabilities
Source Patent Element
Focused ultrasonic waves for target tissue identification
PTD Variation
Real-time signal processing module providing instantaneous feedback on target tissue properties
Obviousness Reasoning
Signal processing enhancements are a standard approach in medical imaging, representing an obvious improvement to existing diagnostic methodologies through well-understood computational techniques
Source Patent Element
Confocal transducer design for tissue border detection
PTD Variation
Adaptive filtering technique to suppress background noise and enhance target tissue visibility
Obviousness Reasoning
Noise reduction and signal enhancement are routine engineering solutions in signal processing, representing a finite set of known techniques that a skilled practitioner would readily implement
Source Patent Element
Ultrasound imaging system for medical diagnostics
PTD Variation
Compact, handheld probe design for enhanced portability and clinical usability
Obviousness Reasoning
Miniaturization and portability are predictable design improvements in medical imaging technologies, representing an obvious evolution of existing device configurations
Source Patent Element
Multi-frequency harmonic acoustography for tissue characterization
PTD Variation
Integration of alternative transducer designs like phased or annular arrays with multiple imaging modalities
Obviousness Reasoning
Transducer array configurations and multi-modal imaging are well-established techniques in medical imaging, representing standard design variations a PHOSITA would consider
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. § 103, the variations disclosed in this Published Technical Disclosure would have been obvious to a person having ordinary skill in the art at the time of invention, when viewed in light of US Patent 11857373. The incremental technological enhancements represent predictable refinements to existing multi-frequency harmonic acoustography methodologies, employing standard engineering design choices and well-understood signal processing techniques within the medical imaging domain.

Original Patent Information

Patent NumberUS 11,857,373
TitleMulti-frequency harmonic acoustography for target identification and border detection
Assignee(s)The Regents of the University of California