Adaptive Endoprosthesis System for Personalized Vasculature Treatment

Publication ID: 24-11857444_0005_PTD

Published: October 28, 2025

Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Adaptive Endoprosthesis System for Personalized Vasculature Treatment,” Published Technical Disclosure No. 24-11857444_0005_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857444_0005_PTD

This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,444.

Summary of the Inventive Concept

A next-generation endoprosthesis system that leverages advanced materials, sensors, and robotic assistance to provide personalized, minimally invasive treatment for complex vasculature conditions.

Background and Problem Solved

The original balloon expandable endoprosthesis, while effective, has limitations in terms of adaptability, precision, and customization. The new inventive concept addresses these limitations by introducing a self-expanding, sensor-enabled, and modular endoprosthesis system that can be tailored to individual patient anatomies and needs.

Detailed Description of the Inventive Concept

The Adaptive Endoprosthesis System comprises a shape-memory alloy that adapts to varying vessel diameters without the need for an external balloon. The system includes an integrated sensor that monitors and adjusts its deployment in real-time, ensuring precise placement and minimizing complications. The modular design allows for interchangeable, 3D-printed components that can be customized for specific patient anatomies. Additionally, the system features a bioabsorbable coating that promotes endothelialization and reduces the risk of restenosis. A robotic-assisted delivery system enables precise, minimally invasive deployment in complex vascular geometries.

Novelty and Inventive Step

The new claims introduce a paradigm shift in endoprosthesis design, moving away from traditional balloon expandable systems and towards adaptive, sensor-enabled, and modular solutions. The inventive step lies in the integration of advanced materials, sensors, and robotic assistance to provide a personalized, minimally invasive treatment option.

Alternative Embodiments and Variations

Alternative embodiments of the Adaptive Endoprosthesis System could include variations in the shape-memory alloy composition, sensor types, and modular component designs. Additionally, the system could be adapted for use in other areas of the body, such as the gastrointestinal tract or respiratory system.

Potential Commercial Applications and Market

The Adaptive Endoprosthesis System has significant commercial potential in the medical device industry, particularly in the areas of cardiovascular and peripheral vascular treatment. The system's ability to provide personalized, minimally invasive treatment options could revolutionize the way vasculature conditions are addressed, leading to improved patient outcomes and reduced healthcare costs.

CPC Classifications

Section	Class	Group
A	A61	A61F2/958
A	A61	A61F2/07
A	A61	A61M25/10
A	A61	A61F2/89
A	A61	A61F2002/072
A	A61	A61F2240/001
A	A61	A61F2240/008
A	A61	A61M2025/1004
A	A61	A61M2025/1068
A	A61	A61M2025/1075
A	A61	A61M2025/1084

Section 103 Obviousness Analysis (PHOSITA)

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Field of Art

Interventional medical devices, specifically endovascular stent-grafts and deployment systems, requiring advanced knowledge of materials science, vascular anatomy, and minimally invasive medical device engineering

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer with expertise in medical device design, materials engineering, and interventional cardiology/vascular surgery techniques, holding advanced degrees and 5-10 years of practical experience in developing endovascular implant technologies

Obviousness Rationale

A PHOSITA would recognize that the PTD's adaptive endoprosthesis represents predictable variations on the source patent's fundamental stent-graft design, utilizing known materials science and medical device engineering principles to enhance deployment flexibility and patient-specific treatment approaches. The core structural and functional elements of balloon-expandable stent systems are systematically modified through well-understood engineering techniques. The proposed innovations represent incremental improvements that would be obvious to a skilled practitioner seeking to optimize endovascular intervention technologies.

Obvious Combinations & Variations

Source Patent Element

Balloon expandable stent-graft with multiple ringed stent elements

PTD Variation

Shape-memory alloy self-expanding stent without external balloon

Obviousness Reasoning

Known alternative expansion mechanisms in medical device design, predictable substitution of mechanical expansion method with shape-memory materials

Source Patent Element

Stent-graft with modular component configuration

PTD Variation

3D-printed interchangeable components for patient-specific anatomies

Obviousness Reasoning

Predictable extension of modular design principles, leveraging additive manufacturing techniques commonly used in medical device customization

Source Patent Element

Endoprosthesis with structural elements between graft layers

PTD Variation

Integrated sensor system for real-time deployment monitoring

Obviousness Reasoning

Logical incorporation of electronic monitoring into existing modular stent-graft architectures, representing a known technique for enhancing medical device performance

Source Patent Element

Balloon-deployed stent-graft system

PTD Variation

Robotic-assisted deployment system for complex vascular geometries

Obviousness Reasoning

Predictable technological progression in minimally invasive medical device deployment, utilizing known robotic surgical assistance techniques

Source Patent Element

Stent-graft with multiple structural elements

PTD Variation

Bioabsorbable coating promoting endothelialization

Obviousness Reasoning

Well-established medical device enhancement technique, representing a finite and predictable solution to improving implant biocompatibility

35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857444 and the principles of medical device engineering, the claimed variations in the Adaptive Endoprosthesis System represent obvious extensions of prior art, wherein a person having ordinary skill in the art would readily conceive of the disclosed technical modifications as predictable and incremental improvements to existing endovascular intervention technologies.

Original Patent Information

Patent Number	US 11,857,444
Title	Balloon expandable endoprosthesis
Assignee(s)	W. L. Gore & Associates, Inc.