Cryogenic Sample Preservation System

Publication ID: 24-11857458_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Cryogenic Sample Preservation System,” Published Technical Disclosure No. 24-11857458_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857458_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,458.

Summary of the Inventive Concept

A novel application of the freezable insert device technology for cryogenic storage and preservation of biological samples, organs, and cells, enabling secure and controlled freezing and thawing processes.

Background and Problem Solved

The original patent focused on alleviating menopausal symptoms, but its core technology can be repurposed to address the limitations of current cryopreservation methods, which often result in sample degradation and loss. The new inventive concept leverages the freezable insert device's ability to maintain a stable temperature and control energy release to preserve the structural integrity of biological samples.

Detailed Description of the Inventive Concept

The Cryogenic Sample Preservation System comprises a freezable insert device adapted for cryogenic storage, with a freezable core assembly designed to preserve the sample's structural integrity during freezing. The system can be used for various biological samples, including tissues, organs, and cells. The device is cooled to a temperature of -20°C or lower, and the sample is inserted and frozen. The system can be integrated with a control system for monitoring and controlling the temperature, ensuring a stable and controlled freezing process.

Novelty and Inventive Step

The new claims introduce a novel application of the freezable insert device technology in the field of cryogenic preservation, providing a non-obvious solution to the limitations of current cryopreservation methods. The inventive step lies in adapting the device's core technology to address the specific challenges of cryogenic storage, ensuring the preservation of biological samples' structural integrity.

Alternative Embodiments and Variations

Alternative embodiments of the Cryogenic Sample Preservation System could include variations in the device's material composition, size, and shape to accommodate different types of biological samples. Additionally, the system could be integrated with advanced temperature control systems, sensors, and automation technologies to further enhance its performance and efficiency.

Potential Commercial Applications and Market

The Cryogenic Sample Preservation System has significant commercial potential in the life sciences and biotechnology industries, particularly in applications such as organ transplantation, cell therapy, and biological sample banking. The system's ability to ensure secure and controlled cryopreservation could revolutionize the way biological samples are stored and utilized, opening up new opportunities for research, development, and clinical applications.

CPC Classifications

SectionClassGroup
A A61 A61F7/12
A A61 A61L31/042
A A61 A61F13/34
A A61 A61F2007/005
A A61 A61F2007/0219
A A61 A61F2007/108
A A61 A61H23/02
A A61 A61H2205/087

Field of Art

Biomedical engineering and medical device design, with specialization in temperature-controlled medical inserts and cryogenic preservation technologies, focusing on thermal management and biological sample handling

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device designer with expertise in thermal engineering, materials science, and biological sample preservation techniques, holding advanced degrees and practical experience in designing temperature-controlled medical devices and cryogenic storage systems

Obviousness Rationale

A PHOSITA would recognize the fundamental similarity between the source patent's freezable insert device and the proposed cryogenic preservation system, understanding that the core thermal management principles can be readily adapted across different application domains. The technical modifications required to transform a vaginal cooling device into a biological sample preservation system represent predictable engineering variations within a known technological framework. The fundamental design elements of controlled temperature insertion, thermal stability, and removable core assembly are directly transferable between the two contexts.

Obvious Combinations & Variations

Source Patent Element
Freezable core assembly with temperature retention capabilities
PTD Variation
Adapting the core assembly for biological sample cryopreservation at significantly lower temperatures
Obviousness Reasoning
A PHOSITA would recognize that thermal management principles are universally applicable, and modifying temperature ranges represents a routine design optimization within predictable engineering parameters
Source Patent Element
String-based removal mechanism
PTD Variation
Utilizing similar retrieval mechanisms for securing and extracting biological samples from cryogenic storage devices
Obviousness Reasoning
The mechanical principles of attachment and removal are consistent across medical device designs, representing a known technique for ensuring safe and controlled extraction
Source Patent Element
Non-toxic gel with controlled temperature release
PTD Variation
Implementing advanced gel compositions for maintaining stable thermal environments during sample preservation
Obviousness Reasoning
Material science techniques for developing temperature-stable gel matrices are well-established, and adapting existing formulations to cryogenic requirements represents a predictable engineering solution
Source Patent Element
Rounded tip design for comfortable insertion
PTD Variation
Ergonomic design principles applied to creating sample-compatible insertion geometries
Obviousness Reasoning
Geometric optimization for minimizing tissue disruption is a standard engineering approach in medical device design, representing an obvious design choice
Source Patent Element
Single-use medical insert concept
PTD Variation
Extending the disposable device paradigm to specialized biological sample storage
Obviousness Reasoning
The concept of single-use, purpose-specific medical devices is a well-established technological strategy, making the adaptation to sample preservation a predictable innovation
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857458 and the disclosed cryogenic preservation system, a person of ordinary skill in the art would find the claimed variations obvious, as the fundamental technological principles of temperature-controlled medical inserts can be readily adapted to biological sample preservation through routine engineering modifications that yield predictable results in thermal management and device design.

Original Patent Information

Patent NumberUS 11,857,458
TitleFreezable insert device