Ultrasound-Enhanced Delivery of Topical Treatments for Skin Conditions

Publication ID: 24-11857459_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Ultrasound-Enhanced Delivery of Topical Treatments for Skin Conditions,” Published Technical Disclosure No. 24-11857459_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857459_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,459.

Summary of the Inventive Concept

The inventive concept applies the core technology of ultrasound-enhanced delivery to the field of dermatology, enabling effective treatment of various skin conditions, such as acne, wrinkles, and skin lesions, using topical creams, collagen, benzoyl peroxide, hair growth serums, and antibiotics.

Background and Problem Solved

The original patent focused on ultrasound-enhanced delivery of drugs for ophthalmic care. However, the technology's potential extends beyond eye care. The inventive concept addresses the limitations of traditional topical treatments for skin conditions, which often struggle with effective penetration and absorption. By leveraging ultrasound technology, the inventive concept overcomes these limitations, providing a more efficient and targeted delivery mechanism.

Detailed Description of the Inventive Concept

The inventive concept comprises an ultrasound-generating device coupled to a topical treatment applicator. The ultrasound signal enhances the delivery of the topical treatment to the target site on the skin, increasing its effectiveness. The applicator is designed to be exchangeable and/or for single-use applications, ensuring ease of use and minimizing the risk of contamination. The system can be configured for various skin conditions, including acne, wrinkles, and skin lesions, by selecting the appropriate topical treatment and adjusting the ultrasound parameters.

Novelty and Inventive Step

The inventive concept introduces a new application of ultrasound-enhanced delivery, expanding the technology's reach into the field of dermatology. The novelty lies in the adaptation of the original technology to address the specific challenges of topical treatments for skin conditions, providing a non-obvious solution to a long-standing problem.

Alternative Embodiments and Variations

Alternative embodiments may include varying the frequency and intensity of the ultrasound signal, using different types of topical treatments, or incorporating additional features such as temperature control or monitoring systems. Variations may also include designing the system for use in different settings, such as clinical or at-home applications.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the dermatology and cosmetic industries, offering a more effective and targeted solution for various skin conditions. The market for topical treatments is substantial, and the inventive concept's ability to enhance their delivery and efficacy positions it for widespread adoption and market penetration.

CPC Classifications

SectionClassGroup
A A61 A61F9/0008
A A61 A61M37/0092
A A61 A61F2250/0093

Field of Art

Medical device technologies for targeted drug/treatment delivery, specifically focusing on ultrasound-enhanced transdermal and transscleral delivery systems, requiring expertise in biomedical engineering, medical device design, and ultrasound physics

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device researcher with advanced degrees, understanding of ultrasound wave propagation, drug delivery mechanisms, and experience designing targeted treatment application systems across different medical domains

Obviousness Rationale

A PHOSITA would recognize the fundamental ultrasound-enhanced delivery mechanism disclosed in the source patent can be readily adapted to different medical treatment contexts by modifying the applicator and target substance while maintaining the core ultrasound signal enhancement principle. The technical transfer from ophthalmic to dermatological applications represents a predictable extension of an established drug delivery technology. The core technological innovation of using ultrasound to improve treatment penetration remains consistent across different medical domains.

Obvious Combinations & Variations

Source Patent Element
Ultrasound transducer for enhancing drug delivery to a specific anatomical target
PTD Variation
Adapting ultrasound transducer for topical skin treatment delivery
Obviousness Reasoning
Known technique of transferring ultrasound-based medical technologies between anatomical domains, with predictable results of improved treatment penetration
Source Patent Element
Exchangeable and single-use drug applicator design
PTD Variation
Applying same applicator design principle to dermatological treatment systems
Obviousness Reasoning
Standard design approach for medical devices, representing an obvious design choice for maintaining sterility and ease of use
Source Patent Element
Ultrasound signal generation for enhancing drug permeation
PTD Variation
Modifying ultrasound parameters for different topical treatment substances
Obviousness Reasoning
Predictable engineering optimization using known ultrasound wave manipulation techniques to improve treatment delivery across different molecular substances
Source Patent Element
Targeted drug delivery system with precise applicator coupling
PTD Variation
Developing skin-specific applicator with similar coupling mechanism
Obviousness Reasoning
Applying known medical device design principles of precise targeting and signal transmission to a new anatomical context
Source Patent Element
Ultrasound-enhanced delivery for intraocular treatments
PTD Variation
Extending technology to dermatological and cosmetic treatments
Obviousness Reasoning
Logical technological progression demonstrating the generalizable nature of ultrasound-enhanced delivery across medical treatment domains
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857459 and the disclosed variations, a person having ordinary skill in the art would find the ultrasound-enhanced delivery system for dermatological treatments obvious and anticipated, as the fundamental technological principles of targeted drug delivery through ultrasound signal modulation remain consistent across medical application domains. The published technical disclosure demonstrates that the claimed innovations represent predictable engineering variations within the established technological framework of ultrasound-enhanced treatment delivery systems.

Original Patent Information

Patent NumberUS 11,857,459
TitleSystem and method for ultrasound-enhanced delivery of drugs
Assignee(s)SONIKURE HOLDINGS LIMITED