Personalized Ultrasound-Enhanced Drug Delivery System with AI, IoT, and Blockchain Integration

Publication ID: 24-11857459_0008_PTD

Published: October 28, 2025

Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Personalized Ultrasound-Enhanced Drug Delivery System with AI, IoT, and Blockchain Integration,” Published Technical Disclosure No. 24-11857459_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857459_0008_PTD

This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,459.

Summary of the Inventive Concept

A novel system that integrates AI, IoT, and blockchain technologies to optimize ultrasound-enhanced drug delivery, ensuring personalized treatment, real-time monitoring, and secure supply chain management.

Background and Problem Solved

The original patent for ultrasound-enhanced delivery of drugs has limitations in terms of personalized treatment and supply chain management. The new inventive concept addresses these limitations by integrating AI, IoT, and blockchain technologies to create a more efficient, secure, and personalized system.

Detailed Description of the Inventive Concept

The new system consists of an AI-powered ultrasound transducer that generates tailored ultrasound waves based on a patient's eye anatomy, an IoT-enabled sensor that monitors eye pressure and temperature, a blockchain-enabled drug tracking module that verifies the authenticity and origin of the delivered drugs, and a machine learning-based controller that optimizes the ultrasound frequency and power based on real-time feedback. The system also includes a nanomaterial-based drug applicator, an AI-powered diagnostic module, and a cloud-based data analytics platform. The inventive concept enables real-time monitoring, personalized treatment, and secure supply chain management.

Novelty and Inventive Step

The new claims introduce the novel integration of AI, IoT, and blockchain technologies with ultrasound-enhanced drug delivery, providing a synergistic combination that significantly improves the original patent's limitations. The inventive step lies in the combination of these distinct technologies to create a more efficient, secure, and personalized system.

Alternative Embodiments and Variations

Alternative embodiments could include using different AI algorithms, IoT sensors, or blockchain platforms. Variations could also include integrating additional technologies, such as augmented reality or 5G networks, to further enhance the system's capabilities.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the ophthalmic care industry, particularly in the treatment of diseases such as central retinal vein occlusion, branch retinal vein occlusion, and age-related macular degeneration. The system's ability to provide personalized treatment, real-time monitoring, and secure supply chain management makes it an attractive solution for healthcare providers and patients alike.

CPC Classifications

Section	Class	Group
A	A61	A61F9/0008
A	A61	A61M37/0092
A	A61	A61F2250/0093

Section 103 Obviousness Analysis (PHOSITA)

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Field of Art

Ophthalmic drug delivery systems, specifically ultrasound-enhanced transscleral drug delivery technologies with a focus on medical device integration, biomedical engineering, and precision drug administration techniques

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device specialist with expertise in ultrasound technologies, drug delivery systems, and advanced medical instrumentation, possessing knowledge of electronic integration, sensor technologies, and pharmaceutical delivery mechanisms

Obviousness Rationale

A PHOSITA would recognize that integrating AI, IoT, and blockchain technologies into the existing ultrasound-enhanced drug delivery framework represents a predictable combination of known technologies to improve system monitoring, personalization, and tracking. The core ultrasound drug delivery mechanism remains fundamentally consistent with the source patent, with the proposed variations representing incremental technological enhancements using standard engineering approaches. The integration of machine learning, sensor technologies, and blockchain tracking would be considered straightforward extensions of existing medical device development practices.

Obvious Combinations & Variations

Source Patent Element

Ultrasound transducer for drug delivery in intraocular spaces

PTD Variation

AI-powered ultrasound transducer generating patient-specific ultrasound waves

Obviousness Reasoning

Customizing ultrasound parameters based on patient characteristics is a predictable optimization technique using known machine learning approaches, representing a routine design improvement

Source Patent Element

Drug applicator with exchangeable/single-use configuration

PTD Variation

Nanomaterial-based drug applicator with integrated IoT sensors for real-time monitoring

Obviousness Reasoning

Enhancing drug applicators with sensor technologies is a standard approach in medical device development, providing additional diagnostic capabilities through predictable technological integration

Source Patent Element

System for delivering drugs to intraocular spaces

PTD Variation

Blockchain-enabled drug tracking module for verifying drug authenticity

Obviousness Reasoning

Implementing supply chain verification through blockchain represents a known technique for improving traceability in medical technologies, offering a straightforward enhancement to existing drug delivery systems

Source Patent Element

Ultrasound-enhanced drug delivery system

PTD Variation

Machine learning-based controller optimizing ultrasound frequency and power

Obviousness Reasoning

Adaptive control systems using machine learning are well-established in medical device technologies, representing a predictable approach to improving treatment precision

Source Patent Element

Drug delivery system with coupling mechanisms

PTD Variation

Cloud-based data analytics platform for tracking patient outcomes

Obviousness Reasoning

Implementing data collection and analysis platforms is a standard approach in medical technologies, providing predictable improvements in treatment monitoring and optimization

35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857459 and the disclosed technological variations, a person of ordinary skill in the art would find the proposed ultrasound-enhanced drug delivery system with AI, IoT, and blockchain integration to be an obvious extension of existing technologies. The combination of known elements produces a predictable result in the field of medical device development, rendering potential claims covering similar technological integrations anticipated and obvious.

Original Patent Information

Patent Number	US 11,857,459
Title	System and method for ultrasound-enhanced delivery of drugs
Assignee(s)	SONIKURE HOLDINGS LIMITED