Enhanced Lacrimal System for Targeted Ocular Drug Delivery

Publication ID: 24-11857461_0001_PTD
Published: October 28, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Enhanced Lacrimal System for Targeted Ocular Drug Delivery,” Published Technical Disclosure No. 24-11857461_0001_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857461_0001_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,461.

Summary of the Inventive Concept

An improved lacrimal system for targeted drug delivery to the eye, featuring innovative designs and technologies to enhance fluid retention, flow control, and patient comfort.

Background and Problem Solved

The original lacrimal system for drug delivery faced limitations in fluid overflow, inconsistent flow rates, and inadequate medication customization. The new inventive concept addresses these issues by introducing advanced features and materials to optimize ocular drug delivery.

Detailed Description of the Inventive Concept

The enhanced lacrimal system comprises a reservoir balloon with an improved exit port design, reducing fluid overflow and increasing ocular surface retention. The tube features a modified lumen configuration for enhanced fluid flow control, and a protective sleeve with a built-in sensor for monitoring fluid delivery rates. Additionally, the system can be programmed to automatically adjust fluid flow rates based on real-time sensor data and ocular surface conditions. The system also features a reservoir balloon with a built-in heating or cooling element to enhance fluid solubility and stability, a tube with an integrated mixing mechanism for preparing customized medication compositions, and a protective sleeve with a self-cleaning feature to minimize bacterial contamination. Furthermore, the system can be configured to receive patient-specific data and adapt fluid delivery rates and medication compositions accordingly.

Novelty and Inventive Step

The new inventive concept introduces a novel combination of advanced features, including the improved exit port design, modified lumen configuration, built-in sensor, and adaptive fluid flow control. These features, along with the integration of heating or cooling elements, mixing mechanisms, and self-cleaning features, provide a significant improvement over the original lacrimal system and demonstrate a non-obvious inventive step.

Alternative Embodiments and Variations

Alternative embodiments of the enhanced lacrimal system could include variations in the reservoir balloon material, tube geometry, and sensor design. Additionally, the system could be adapted for use in other ocular or nasal applications, or integrated with other medical devices to provide a comprehensive treatment platform.

Potential Commercial Applications and Market

The enhanced lacrimal system has significant commercial potential in the ophthalmic and pharmaceutical industries, offering a targeted and efficient means of delivering medications to the eye. The system's adaptability and customization capabilities make it an attractive solution for a wide range of ocular conditions and diseases, with potential applications in glaucoma treatment, dry eye management, and beyond.

CPC Classifications

SectionClassGroup
A A61 A61F9/00772
A A61 A61F9/0017
A A61 A61M37/00
A A61 A61M31/002

Original Patent Information

Patent NumberUS 11,857,461
TitleLacrimal system for drug delivery
Assignee(s)The Regents of the University of Colorado, a body corporate