Next-Generation Lacrimal System for Targeted and Controlled Drug Delivery

Publication ID: 24-11857461_0005_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Next-Generation Lacrimal System for Targeted and Controlled Drug Delivery,” Published Technical Disclosure No. 24-11857461_0005_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857461_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,461.

Summary of the Inventive Concept

A revolutionary lacrimal system that leverages cutting-edge technologies to provide targeted, controlled, and sustained drug delivery to the eye, overcoming limitations of existing systems.

Background and Problem Solved

Current lacrimal systems for drug delivery face challenges in achieving precise control over drug release, leading to inadequate treatment outcomes. The original patent's lacrimal system, while innovative, has limitations in terms of controlled release and targeted delivery. The new inventive concept addresses these limitations by incorporating advanced technologies, such as MEMS-based pumps, micro-needle arrays, and nanotechnology-based targeted delivery systems.

Detailed Description of the Inventive Concept

The next-generation lacrimal system comprises a self-sustaining, bio-compatible implantable reservoir device with a porous surface for controlled release of therapeutic agents. The system can also include a wearable, miniaturized, and flexible device with a micro-needle array for trans-scleral delivery or a smart contact lens with a micro-reservoir and micro-pump for controlled release. Additionally, the system can utilize nanotechnology-based targeted drug delivery systems, comprising nanoparticles loaded with therapeutic agents and targeted to specific cells or tissues in the eye. These components work in tandem to provide precise control over drug release, ensuring optimal treatment outcomes.

Novelty and Inventive Step

The new claims introduce significant advancements in controlled release and targeted delivery, overcoming the limitations of the original patent. The incorporation of MEMS-based pumps, micro-needle arrays, and nanotechnology-based targeted delivery systems provides a novel and non-obvious solution for lacrimal system-based drug delivery.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of bio-absorbable materials, wireless communication for real-time monitoring, or integration with artificial intelligence for personalized treatment. Variations could include adapting the system for delivery of other therapeutic agents, such as gene therapy or stem cells, or for use in other ocular diseases or disorders.

Potential Commercial Applications and Market

The next-generation lacrimal system has vast commercial potential in the ophthalmic industry, with applications in treating a range of ocular diseases and disorders, including glaucoma, dry eye, and age-related macular degeneration. The system's targeted and controlled delivery capabilities make it an attractive solution for pharmaceutical companies and healthcare providers seeking to improve treatment outcomes and reduce healthcare costs.

CPC Classifications

SectionClassGroup
A A61 A61F9/00772
A A61 A61F9/0017
A A61 A61M37/00
A A61 A61M31/002

Original Patent Information

Patent NumberUS 11,857,461
TitleLacrimal system for drug delivery
Assignee(s)The Regents of the University of Colorado, a body corporate