Cryogenic Preservation and Treatment Systems for Biological Samples, Organs, Vaccines, Cancer Cells, and Food Products

Publication ID: 24-11857491_0002_PTD

Published: October 28, 2025

Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Cryogenic Preservation and Treatment Systems for Biological Samples, Organs, Vaccines, Cancer Cells, and Food Products,” Published Technical Disclosure No. 24-11857491_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857491_0002_PTD

This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,491.

Summary of the Inventive Concept

The present inventive concept expands the core technology of the original integrated cold therapy-compression therapy assembly to entirely new industries and applications, including cryogenic preservation of biological samples, organs, vaccines, cancer cells, and food products.

Background and Problem Solved

The original patent focused on medical devices for applying cold therapy and compression therapy to patients. However, the limitations of the original patent did not consider the vast potential of cryogenic preservation and treatment in various industries. The present inventive concept addresses this gap by leveraging the core technology to develop innovative solutions for cryogenic preservation and treatment of biological samples, organs, vaccines, cancer cells, and food products.

Detailed Description of the Inventive Concept

The inventive concept comprises a system for cryogenic preservation of biological samples, organs, vaccines, cancer cells, and food products, utilizing an integrated cold therapy-compression therapy assembly. The assembly includes a coolant reservoir containing a cryogenic fluid, a treatment pad or storage compartment designed to maintain a temperature below -80°C, and a control unit regulating the temperature and pressure of the cryogenic fluid. The system enables long-term preservation of biological samples, organs, vaccines, and food products, and facilitates cryogenic treatment of cancer cells.

Novelty and Inventive Step

The new claims introduce novel applications and use cases for the core technology, expanding its scope beyond medical devices. The inventive step lies in the adaptation of the integrated cold therapy-compression therapy assembly to cryogenic preservation and treatment of biological samples, organs, vaccines, cancer cells, and food products, addressing unmet needs in these industries.

Alternative Embodiments and Variations

Alternative embodiments may include modular designs for different industries, customized treatment pads or storage compartments for specific applications, and variations in cryogenic fluid composition or temperature control mechanisms. These variations ensure broad conceptual coverage and adaptability to diverse industry requirements.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in industries such as biotechnology, organ transplantation, vaccine development, cancer research, and food processing. The market demand for effective cryogenic preservation and treatment solutions is substantial, and the present inventive concept is poised to capture a significant share of this market.

CPC Classifications

Section	Class	Group
A	A61	A61H9/0092
A	A61	A61F7/0085
A	A61	A61F2007/0042
A	A61	A61F2007/0056
A	A61	A61H2201/0207
A	A61	A61H2201/0214
A	A61	A61H2201/0242
A	A61	A61H2201/5023
A	A61	A61H2201/5071
A	A61	A61H2205/102

Section 103 Obviousness Analysis (PHOSITA)

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Field of Art

Medical device technology, specifically cold therapy and cryogenic preservation systems, involving thermal management, fluid control, and precision temperature regulation across medical, biological, and food preservation applications

Person of Ordinary Skill (PHOSITA) Profile

A biomedical engineer or medical device designer with expertise in thermal engineering, fluid dynamics, temperature control systems, and cross-industry adaptation of medical technologies, holding at least a master's degree with 3-5 years of practical experience

Obviousness Rationale

A PHOSITA would recognize that the core cold therapy-compression technology disclosed in the source patent represents a fundamental thermal management system readily adaptable to multiple preservation and treatment contexts. The integrated coolant reservoir, temperature control mechanisms, and fluid delivery systems are fundamentally transferable across different application domains. The technical principles governing cryogenic preservation are sufficiently well-understood that extending medical device technology to biological sample, organ, vaccine, and food preservation would be a predictable engineering variation.

Obvious Combinations & Variations

Source Patent Element

Reservoir container configured to contain coolant with a mixing chamber and temperature-controlled pump system

PTD Variation

Adapting the reservoir container to hold cryogenic fluids for preserving biological samples and food products at ultra-low temperatures

Obviousness Reasoning

Predictable modification of existing thermal management system to handle different fluid types and temperature ranges, representing a straightforward design adaptation

Source Patent Element

Microprocessor controlling coolant pump operation

PTD Variation

Extending microprocessor control to regulate precise temperature and pressure for cryogenic preservation of sensitive biological materials

Obviousness Reasoning

Known technique of using programmable control systems to manage complex thermal parameters across different application contexts

Source Patent Element

Integrated cold therapy and compression therapy assembly

PTD Variation

Repurposing assembly for cryogenic treatment of cancer cells and long-term preservation of organs and vaccines

Obviousness Reasoning

Finite set of identifiable applications for a flexible thermal management system, representing an obvious technological extension

Source Patent Element

Treatment pad configured for applying coolant

PTD Variation

Modifying treatment pad design to maintain temperatures below -80°C for specialized preservation and treatment scenarios

Obviousness Reasoning

Routine engineering modification involving material selection and thermal insulation techniques well-known in cryogenic engineering

Source Patent Element

Coolant reservoir with fluid circulation mechanisms

PTD Variation

Implementing specialized fluid circulation for maintaining consistent ultra-low temperatures in biological and food preservation contexts

Obviousness Reasoning

Predictable application of existing fluid management principles to new preservation domains

35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857491 and the published technical disclosure, a person having ordinary skill in the art would find the claimed variations in cryogenic preservation systems obvious, as the fundamental thermal management principles and integrated cold therapy technologies represent a predictable extension of existing medical device engineering techniques across multiple application domains.

Original Patent Information

Patent Number	US 11,857,491
Title	Integrated cold therapy-compression therapy assembly and associated treatment protocols
Assignee(s)	Breg, Inc.