pH-Sensitive Liposome Compositions for Environmental and Agricultural Applications

Publication ID: 24-11857509_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “pH-Sensitive Liposome Compositions for Environmental and Agricultural Applications,” Published Technical Disclosure No. 24-11857509_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857509_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,509.

Summary of the Inventive Concept

This inventive concept leverages pH-sensitive liposome technology to develop novel systems for monitoring soil health, detecting water contamination, monitoring food spoilage, enhancing crop yields, and monitoring industrial process water quality.

Background and Problem Solved

The original patent focused on delivering molecules to cells for cancer treatment. However, this technology has broader applications in environmental and agricultural fields, where pH-sensitive liposomes can be used to detect and respond to acidic conditions. The new inventive concept addresses the need for real-time monitoring and early detection of soil health, water contamination, food spoilage, and industrial process water quality issues.

Detailed Description of the Inventive Concept

The pH-sensitive liposome compositions comprise liposomes that release fluorescent indicators, detectable signals, or colorimetric indicators upon encountering acidic conditions. These liposomes can be designed to target specific applications, such as monitoring soil pH levels, detecting water pollution, monitoring food freshness, enhancing crop yields, or monitoring industrial process water quality. The liposomes' pH-sensitivity enables them to respond to changes in their environment, providing real-time monitoring and detection capabilities.

Novelty and Inventive Step

The new claims introduce novel applications of pH-sensitive liposome technology in environmental and agricultural fields, which were not considered in the original patent. The inventive step lies in adapting the core technology to address specific problems in these fields, such as soil health monitoring, water contamination detection, and food spoilage monitoring.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include using different types of liposomes, such as cationic or anionic liposomes, or incorporating additional components, such as nanoparticles or enzymes, to enhance the system's sensitivity and specificity. Variations could also include using different detection methods, such as electrochemical or optical detection, or integrating the pH-sensitive liposome technology with existing monitoring systems.

Potential Commercial Applications and Market

The pH-sensitive liposome technology has significant commercial potential in environmental and agricultural industries, including soil health monitoring, water quality monitoring, food safety monitoring, and industrial process control. The target market includes companies involved in environmental monitoring, agricultural production, food processing, and industrial water treatment.

CPC Classifications

SectionClassGroup
A A61 A61K9/1271
A A61 A61K9/127
A A61 A61K31/20
A A61 A61K31/337
A A61 A61K31/704
A A61 A61K31/711
A A61 A61K31/713
A A61 A61K31/7105
A A61 A61K47/6911
A A61 A61P35/00

Field of Art

Pharmaceutical and biotechnology drug delivery systems, with expertise in liposomal technologies, targeted drug delivery, and pH-sensitive carrier systems

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degrees in pharmaceutical sciences, biochemistry, or chemical engineering, possessing knowledge of liposomal drug delivery mechanisms, surface modification techniques, and environmental sensing technologies

Obviousness Rationale

A PHOSITA would recognize the natural extension of pH-sensitive liposome technology from medical applications to environmental monitoring by leveraging the core technical principles of pH-triggered cargo release. The fundamental mechanism of pH-sensitive liposomes remains consistent across different application domains, making the environmental and agricultural adaptations a straightforward and predictable variation of the source patent's core technology.

Obvious Combinations & Variations

Source Patent Element
pH-triggered liposome cargo delivery mechanism using pHLIP technology
PTD Variation
Adapting pH-sensitive liposomes to release fluorescent indicators in soil and water environments
Obviousness Reasoning
Known technique of modifying liposome cargo for different detection purposes, with predictable results in sensing applications
Source Patent Element
Liposome membrane fusion and cellular cargo delivery
PTD Variation
Using liposomes to release growth-promoting agents in agricultural contexts based on pH conditions
Obviousness Reasoning
Predictable extension of targeted delivery concept to agricultural systems, representing a finite and obvious solution to enhancing crop management
Source Patent Element
Selective targeting of specific cellular environments using pH sensitivity
PTD Variation
Monitoring food spoilage and industrial water quality through pH-triggered signal release
Obviousness Reasoning
Design choice applying known liposomal sensing principles to alternative environmental monitoring scenarios
Source Patent Element
Cargo-loaded liposomes with specific membrane characteristics
PTD Variation
Incorporating alternative liposome compositions like cationic or anionic variants for enhanced environmental sensing
Obviousness Reasoning
Known variation technique in liposome design, representing a standard approach for optimizing delivery and sensing capabilities
Source Patent Element
pH-triggered molecular release mechanism
PTD Variation
Expanding detection methods to include electrochemical and optical signaling approaches
Obviousness Reasoning
Obvious combination of known detection technologies with established liposomal cargo release principles
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857509 regarding pH-sensitive liposome technologies, the present publication demonstrates that the extension of targeted liposomal cargo delivery to environmental and agricultural monitoring represents an obvious variation to a Person Having Ordinary Skill In The Art. The disclosed variations constitute prima facie obviousness by applying known liposomal mechanisms to alternative technical domains with predictable and expected results.

Original Patent Information

Patent NumberUS 11,857,509
TitleLiposome compositions and methods of use thereof
Assignee(s)Yale University, University of Rhode Island Board of Trustees