pH-Sensitive Liposome Compositions for Environmental and Agricultural Applications

Publication ID: 24-11857509_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “pH-Sensitive Liposome Compositions for Environmental and Agricultural Applications,” Published Technical Disclosure No. 24-11857509_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857509_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,509.

Summary of the Inventive Concept

This inventive concept leverages pH-sensitive liposome technology to develop novel systems for monitoring soil health, detecting water contamination, monitoring food spoilage, enhancing crop yields, and monitoring industrial process water quality.

Background and Problem Solved

The original patent focused on delivering molecules to cells for cancer treatment. However, this technology has broader applications in environmental and agricultural fields, where pH-sensitive liposomes can be used to detect and respond to acidic conditions. The new inventive concept addresses the need for real-time monitoring and early detection of soil health, water contamination, food spoilage, and industrial process water quality issues.

Detailed Description of the Inventive Concept

The pH-sensitive liposome compositions comprise liposomes that release fluorescent indicators, detectable signals, or colorimetric indicators upon encountering acidic conditions. These liposomes can be designed to target specific applications, such as monitoring soil pH levels, detecting water pollution, monitoring food freshness, enhancing crop yields, or monitoring industrial process water quality. The liposomes' pH-sensitivity enables them to respond to changes in their environment, providing real-time monitoring and detection capabilities.

Novelty and Inventive Step

The new claims introduce novel applications of pH-sensitive liposome technology in environmental and agricultural fields, which were not considered in the original patent. The inventive step lies in adapting the core technology to address specific problems in these fields, such as soil health monitoring, water contamination detection, and food spoilage monitoring.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include using different types of liposomes, such as cationic or anionic liposomes, or incorporating additional components, such as nanoparticles or enzymes, to enhance the system's sensitivity and specificity. Variations could also include using different detection methods, such as electrochemical or optical detection, or integrating the pH-sensitive liposome technology with existing monitoring systems.

Potential Commercial Applications and Market

The pH-sensitive liposome technology has significant commercial potential in environmental and agricultural industries, including soil health monitoring, water quality monitoring, food safety monitoring, and industrial process control. The target market includes companies involved in environmental monitoring, agricultural production, food processing, and industrial water treatment.

CPC Classifications

SectionClassGroup
A A61 A61K9/1271
A A61 A61K9/127
A A61 A61K31/20
A A61 A61K31/337
A A61 A61K31/704
A A61 A61K31/711
A A61 A61K31/713
A A61 A61K31/7105
A A61 A61K47/6911
A A61 A61P35/00

Original Patent Information

Patent NumberUS 11,857,509
TitleLiposome compositions and methods of use thereof
Assignee(s)Yale University, University of Rhode Island Board of Trustees