pH-Sensitive Liposome Compositions for Environmental and Agricultural Applications
Legal Citation
Summary of the Inventive Concept
This inventive concept leverages pH-sensitive liposome technology to develop novel systems for monitoring soil health, detecting water contamination, monitoring food spoilage, enhancing crop yields, and monitoring industrial process water quality.
Background and Problem Solved
The original patent focused on delivering molecules to cells for cancer treatment. However, this technology has broader applications in environmental and agricultural fields, where pH-sensitive liposomes can be used to detect and respond to acidic conditions. The new inventive concept addresses the need for real-time monitoring and early detection of soil health, water contamination, food spoilage, and industrial process water quality issues.
Detailed Description of the Inventive Concept
The pH-sensitive liposome compositions comprise liposomes that release fluorescent indicators, detectable signals, or colorimetric indicators upon encountering acidic conditions. These liposomes can be designed to target specific applications, such as monitoring soil pH levels, detecting water pollution, monitoring food freshness, enhancing crop yields, or monitoring industrial process water quality. The liposomes' pH-sensitivity enables them to respond to changes in their environment, providing real-time monitoring and detection capabilities.
Novelty and Inventive Step
The new claims introduce novel applications of pH-sensitive liposome technology in environmental and agricultural fields, which were not considered in the original patent. The inventive step lies in adapting the core technology to address specific problems in these fields, such as soil health monitoring, water contamination detection, and food spoilage monitoring.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include using different types of liposomes, such as cationic or anionic liposomes, or incorporating additional components, such as nanoparticles or enzymes, to enhance the system's sensitivity and specificity. Variations could also include using different detection methods, such as electrochemical or optical detection, or integrating the pH-sensitive liposome technology with existing monitoring systems.
Potential Commercial Applications and Market
The pH-sensitive liposome technology has significant commercial potential in environmental and agricultural industries, including soil health monitoring, water quality monitoring, food safety monitoring, and industrial process control. The target market includes companies involved in environmental monitoring, agricultural production, food processing, and industrial water treatment.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K9/1271 |
| A | A61 | A61K9/127 |
| A | A61 | A61K31/20 |
| A | A61 | A61K31/337 |
| A | A61 | A61K31/704 |
| A | A61 | A61K31/711 |
| A | A61 | A61K31/713 |
| A | A61 | A61K31/7105 |
| A | A61 | A61K47/6911 |
| A | A61 | A61P35/00 |
Original Patent Information
| Patent Number | US 11,857,509 |
|---|---|
| Title | Liposome compositions and methods of use thereof |
| Assignee(s) | Yale University, University of Rhode Island Board of Trustees |